DegronMD - Q9UPP2(IQSEC3)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P348T	TCGA-05-4382	LUAD	TCGA	RRISLRKVR	DEG_APCC_DBOX_1	349:357	Mutation rewiring degron network	0.3056
p.P348T	DO24900	LUAD	ICGC	RRISLRKVR	DEG_APCC_DBOX_1	349:357	Mutation rewiring degron network	0.3056
p.A365E	TCGA-43-A56V	LUSC	TCGA	RRISLRKVR	DEG_APCC_DBOX_1	349:357	Mutation rewiring degron network	0.1111
p.A365E	DO45535	LUSC	ICGC	RRISLRKVR	DEG_APCC_DBOX_1	349:357	Mutation rewiring degron network	0.1111
p.E362Q	TCGA-66-2785	LUSC	TCGA	RRISLRKVR	DEG_APCC_DBOX_1	349:357	Mutation rewiring degron network	0.1944
p.E362Q	DO26520	LUSC	ICGC	RRISLRKVR	DEG_APCC_DBOX_1	349:357	Mutation rewiring degron network	0.1944
p.P1086A	TCGA-75-7031	LUAD	TCGA	PPPTPPGT	DEG_SCF_FBW7_1	1082:1089	Mutation altering degron motif	0.7503
p.P1086A	DO25545	LUAD	ICGC	PPPTPPGT	DEG_SCF_FBW7_1	1082:1089	Mutation altering degron motif	0.7503
p.R349W	TCGA-76-4925	GBM	TCGA	RRISLRKVR	DEG_APCC_DBOX_1	349:357	Mutation altering degron motif	0.7523
p.R349W	TCGA-VQ-A8PD	STAD	TCGA	RRISLRKVR	DEG_APCC_DBOX_1	349:357	Mutation altering degron motif	0.7523
p.R349W	DO12124	GBM	ICGC	RRISLRKVR	DEG_APCC_DBOX_1	349:357	Mutation altering degron motif	0.7523
p.R349W	DO51768	STAD	ICGC	RRISLRKVR	DEG_APCC_DBOX_1	349:357	Mutation altering degron motif	0.7523
p.L364M	TCGA-95-7043	LUAD	TCGA	RRISLRKVR	DEG_APCC_DBOX_1	349:357	Mutation rewiring degron network	0.1389
p.L364M	DO24739	LUAD	ICGC	RRISLRKVR	DEG_APCC_DBOX_1	349:357	Mutation rewiring degron network	0.1389
p.E367D	TCGA-A5-A2K5	UCEC	TCGA	RRISLRKVR	DEG_APCC_DBOX_1	349:357	Mutation rewiring degron network	0.0556
p.E367D	DO41379	UCEC	ICGC	RRISLRKVR	DEG_APCC_DBOX_1	349:357	Mutation rewiring degron network	0.0556
p.S363C	TCGA-AN-A0XR	BRCA	TCGA	RRISLRKVR	DEG_APCC_DBOX_1	349:357	Mutation rewiring degron network	0.1667
p.S363C	DO3412	BRCA	ICGC	RRISLRKVR	DEG_APCC_DBOX_1	349:357	Mutation rewiring degron network	0.1667
p.L901M	TCGA-B5-A11E	UCEC	TCGA	VFLFND	LIG_APCC_ABBA_1	895:900	Mutation rewiring degron network	0.3056
p.L901M	DO41644	UCEC	ICGC	VFLFND	LIG_APCC_ABBA_1	895:900	Mutation rewiring degron network	0.3056
p.P348Q	TCGA-BF-A5EO	SKCM	TCGA	RRISLRKVR	DEG_APCC_DBOX_1	349:357	Mutation rewiring degron network	0.3056
p.P348Q	DO219450	SKCM	ICGC	RRISLRKVR	DEG_APCC_DBOX_1	349:357	Mutation rewiring degron network	0.3056
p.Q888H	TCGA-CM-6171	COAD	TCGA	VFLFND	LIG_APCC_ABBA_1	895:900	Mutation rewiring degron network	0.1389
p.Q888H	DO8151	COAD	ICGC	VFLFND	LIG_APCC_ABBA_1	895:900	Mutation rewiring degron network	0.1389
p.A366V	TCGA-DI-A1BU	UCEC	TCGA	RRISLRKVR	DEG_APCC_DBOX_1	349:357	Mutation rewiring degron network	0.0833
p.A366V	DO42023	UCEC	ICGC	RRISLRKVR	DEG_APCC_DBOX_1	349:357	Mutation rewiring degron network	0.0833
p.A890T	TCGA-DI-A1BU	UCEC	TCGA	VFLFND	LIG_APCC_ABBA_1	895:900	Mutation rewiring degron network	0.1944
p.A890T	DO42023	UCEC	ICGC	VFLFND	LIG_APCC_ABBA_1	895:900	Mutation rewiring degron network	0.1944
p.T1089I	TCGA-EB-A3Y6	SKCM	TCGA	PPPTPPGT	DEG_SCF_FBW7_1	1082:1089	Mutation altering degron motif	0.7078
p.T1089I	DO38081	SKCM	ICGC	PPPTPPGT	DEG_SCF_FBW7_1	1082:1089	Mutation altering degron motif	0.7078
p.R339C	TCGA-EB-A41B	SKCM	TCGA	RRISLRKVR	DEG_APCC_DBOX_1	349:357	Mutation rewiring degron network	0.0556
p.R339C	DO37611	SKCM	ICGC	RRISLRKVR	DEG_APCC_DBOX_1	349:357	Mutation rewiring degron network	0.0556
p.P1155L	TCGA-EB-A4XL	SKCM	TCGA	PPPY	ITCH	1153:1156	Mutation altering degron motif	0.6471
p.P1155L	DO47401	SKCM	ICGC	PPPY	ITCH	1153:1156	Mutation altering degron motif	0.6471
p.P909L	TCGA-EJ-A7NF	PRAD	TCGA	VFLFND	LIG_APCC_ABBA_1	895:900	Mutation rewiring degron network	0.0833
p.P909L	DO10806	EOPC	ICGC	VFLFND	LIG_APCC_ABBA_1	895:900	Mutation rewiring degron network	0.0833
p.P909L	DO51321	PRAD	ICGC	VFLFND	LIG_APCC_ABBA_1	895:900	Mutation rewiring degron network	0.0833
p.R350W	TCGA-FI-A2D5	UCEC	TCGA	RRISLRKVR	DEG_APCC_DBOX_1	349:357	Mutation altering degron motif	0.8634
p.R350W	DO41331	UCEC	ICGC	RRISLRKVR	DEG_APCC_DBOX_1	349:357	Mutation altering degron motif	0.8634
p.P1081L	TCGA-GD-A3OQ	BLCA	TCGA	PPPTPPGT	DEG_SCF_FBW7_1	1082:1089	Mutation rewiring degron network	0.3056
p.P1081L	DO506	BLCA	ICGC	PPPTPPGT	DEG_SCF_FBW7_1	1082:1089	Mutation rewiring degron network	0.3056
p.F898L	TCGA-UY-A78P	BLCA	TCGA	VFLFND	LIG_APCC_ABBA_1	895:900	Mutation altering degron motif	0.6981
p.F898L	DO219036	BLCA	ICGC	VFLFND	LIG_APCC_ABBA_1	895:900	Mutation altering degron motif	0.6981
p.E362K	DO48396	BLCA	ICGC	RRISLRKVR	DEG_APCC_DBOX_1	349:357	Mutation rewiring degron network	0.1944
p.R357P	DO222404	BTCA	ICGC	RRISLRKVR	DEG_APCC_DBOX_1	349:357	Mutation altering degron motif	0.6401
p.Y1156H	DO52727	CMDI	ICGC	PPPY	ITCH	1153:1156	Mutation altering degron motif	0.7229
p.Y1156H	DO229232	THCA	ICGC	PPPY	ITCH	1153:1156	Mutation altering degron motif	0.7229
p.P1164S	DO9876	COAD	ICGC	PPPY	ITCH	1153:1156	Mutation rewiring degron network	0.1111
p.H891Q	DO233767	GACA	ICGC	VFLFND	LIG_APCC_ABBA_1	895:900	Mutation rewiring degron network	0.2222
p.T1144S	DO233910	GACA	ICGC	PPPY	ITCH	1153:1156	Mutation rewiring degron network	0.0833
p.V1097F	DO229028	LICA	ICGC	PPPTPPGT	DEG_SCF_FBW7_1	1082:1089	Mutation rewiring degron network	0.1111
p.P1164L	DO220878	MELA	ICGC	PPPY	ITCH	1153:1156	Mutation rewiring degron network	0.1111
p.P1164L	DO220906	MELA	ICGC	PPPY	ITCH	1153:1156	Mutation rewiring degron network	0.1111
p.A361D	DO27901	ORCA	ICGC	RRISLRKVR	DEG_APCC_DBOX_1	349:357	Mutation rewiring degron network	0.2222
p.R339H	DO49424	PACA	ICGC	RRISLRKVR	DEG_APCC_DBOX_1	349:357	Mutation rewiring degron network	0.0556
p.R357W	DO232761	PBCA	ICGC	RRISLRKVR	DEG_APCC_DBOX_1	349:357	Mutation altering degron motif	0.7523
p.P1086H	DO219871	SKCA	ICGC	PPPTPPGT	DEG_SCF_FBW7_1	1082:1089	Mutation altering degron motif	0.7694
p.G1166C	SIDM00216	Colorectal Carcinoma	GDSC	PPPY	ITCH	1153:1156	Mutation rewiring degron network	0.0556
p.G1166C	SNU-175	large intestine	COSMIC	PPPY	ITCH	1153:1156	Mutation rewiring degron network	0.0556
p.Q1092E	SIDM00915	Small Cell Lung Carcinoma	GDSC	PPPTPPGT	DEG_SCF_FBW7_1	1082:1089	Mutation rewiring degron network	0.25
p.Q1092E	SIDM00995	Other Solid Cancers	GDSC	PPPTPPGT	DEG_SCF_FBW7_1	1082:1089	Mutation rewiring degron network	0.25
p.Q1092E	A431	skin	COSMIC	PPPTPPGT	DEG_SCF_FBW7_1	1082:1089	Mutation rewiring degron network	0.25
p.P1159S	SIDM00585	Hepatocellular Carcinoma	GDSC	PPPY	ITCH	1153:1156	Mutation rewiring degron network	0.25
p.P1159S	ACH-000480	Liver Cancer	CCLE	PPPY	ITCH	1153:1156	Mutation rewiring degron network	0.25
p.P1159S	HuH-7	liver	COSMIC	PPPY	ITCH	1153:1156	Mutation rewiring degron network	0.25
p.G1088D	SIDM00251	Gastric Carcinoma	GDSC	PPPTPPGT	DEG_SCF_FBW7_1	1082:1089	Mutation altering degron motif	0.6087
p.G1088D	ACH-000949	Gastric Cancer	CCLE	PPPTPPGT	DEG_SCF_FBW7_1	1082:1089	Mutation altering degron motif	0.6087
p.G1088D	TGBC11TKB	stomach	COSMIC	PPPTPPGT	DEG_SCF_FBW7_1	1082:1089	Mutation altering degron motif	0.6087
p.I1096T	SIDM01018	Hodgkin's Lymphoma	GDSC	PPPTPPGT	DEG_SCF_FBW7_1	1082:1089	Mutation rewiring degron network	0.1389
p.I1096T	ACH-000815	Lymphoma	CCLE	PPPTPPGT	DEG_SCF_FBW7_1	1082:1089	Mutation rewiring degron network	0.1389
p.I1096T	KM-H2	haematopoietic and lymphoid tissue	COSMIC	PPPTPPGT	DEG_SCF_FBW7_1	1082:1089	Mutation rewiring degron network	0.1389
p.T360P	ACH-000499	Bone Cancer	CCLE	RRISLRKVR	DEG_APCC_DBOX_1	349:357	Mutation blocking phosphorylation signal	0.6944
p.T360P	ACH-002194	Bone Cancer	CCLE	RRISLRKVR	DEG_APCC_DBOX_1	349:357	Mutation blocking phosphorylation signal	0.6944
p.T360P	RH-1	soft tissue	COSMIC	RRISLRKVR	DEG_APCC_DBOX_1	349:357	Mutation blocking phosphorylation signal	0.6944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

IQSEC3

UniProt ID: Q9UPP2

Entrez ID: 440073

Protein name: IQ motif and SEC7 domain-containing protein 3

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for IQSEC3 in