DegronMD

Uniprot ID: Q9UPP2

Source protein: IQ motif and SEC7 domain-containing protein 3

Source gene: IQSEC3

Class: DEG_SCF_FBW7_1

Location: 1082:1089

E3 ligase: FBXW7

DEGRON score: 0.9755

ASA_SCORE: 82.475

COIL: 0.9326

CONS_SCORE: 0.3338

DSS_SCORE: 0.6735

HELIX: 0.0436

FCONS_SCORE: 1.0578

RIG_SCORE: 0.5513

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P1086A	TCGA-75-7031	LUAD	TCGA	PPPTPPGT	DEG_SCF_FBW7_1	0.7503
p.P1086A	DO25545	LUAD	ICGC	PPPTPPGT	DEG_SCF_FBW7_1	0.7503
p.T1089I	TCGA-EB-A3Y6	SKCM	TCGA	PPPTPPGT	DEG_SCF_FBW7_1	0.7078
p.T1089I	DO38081	SKCM	ICGC	PPPTPPGT	DEG_SCF_FBW7_1	0.7078
p.P1081L	TCGA-GD-A3OQ	BLCA	TCGA	PPPTPPGT	DEG_SCF_FBW7_1	0.3056
p.P1081L	DO506	BLCA	ICGC	PPPTPPGT	DEG_SCF_FBW7_1	0.3056
p.V1097F	DO229028	LICA	ICGC	PPPTPPGT	DEG_SCF_FBW7_1	0.1111
p.P1086H	DO219871	SKCA	ICGC	PPPTPPGT	DEG_SCF_FBW7_1	0.7694
p.Q1092E	SIDM00915	Small Cell Lung Carcinoma	GDSC	PPPTPPGT	DEG_SCF_FBW7_1	0.25
p.Q1092E	SIDM00995	Other Solid Cancers	GDSC	PPPTPPGT	DEG_SCF_FBW7_1	0.25
p.Q1092E	A431	skin	COSMIC	PPPTPPGT	DEG_SCF_FBW7_1	0.25
p.G1088D	SIDM00251	Gastric Carcinoma	GDSC	PPPTPPGT	DEG_SCF_FBW7_1	0.6087
p.G1088D	ACH-000949	Gastric Cancer	CCLE	PPPTPPGT	DEG_SCF_FBW7_1	0.6087
p.G1088D	TGBC11TKB	stomach	COSMIC	PPPTPPGT	DEG_SCF_FBW7_1	0.6087
p.I1096T	SIDM01018	Hodgkin's Lymphoma	GDSC	PPPTPPGT	DEG_SCF_FBW7_1	0.1389
p.I1096T	ACH-000815	Lymphoma	CCLE	PPPTPPGT	DEG_SCF_FBW7_1	0.1389
p.I1096T	KM-H2	haematopoietic_and_lymphoid_tissue	COSMIC	PPPTPPGT	DEG_SCF_FBW7_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UPP2	IQ motif and SEC7 domain-containing protein 3	DEG_SCF_FBW7_1	1082:1089	PPPTPPGT	FBXW7	0.9755	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons