DegronMD

Uniprot ID: Q9UPP2

Source protein: IQ motif and SEC7 domain-containing protein 3

Source gene: IQSEC3

Class: DEG_APCC_DBOX_1

Location: 349:357

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.976

ASA_SCORE: 115.6556

COIL: 0.7121

CONS_SCORE: 0.4542

DSS_SCORE: 0.3398

HELIX: 0.142

FCONS_SCORE: 1.2136

RIG_SCORE: 0.7607

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P348T	TCGA-05-4382	LUAD	TCGA	RRISLRKVR	DEG_APCC_DBOX_1	0.3056
p.P348T	DO24900	LUAD	ICGC	RRISLRKVR	DEG_APCC_DBOX_1	0.3056
p.A365E	TCGA-43-A56V	LUSC	TCGA	RRISLRKVR	DEG_APCC_DBOX_1	0.1111
p.A365E	DO45535	LUSC	ICGC	RRISLRKVR	DEG_APCC_DBOX_1	0.1111
p.E362Q	TCGA-66-2785	LUSC	TCGA	RRISLRKVR	DEG_APCC_DBOX_1	0.1944
p.E362Q	DO26520	LUSC	ICGC	RRISLRKVR	DEG_APCC_DBOX_1	0.1944
p.R349W	TCGA-76-4925	GBM	TCGA	RRISLRKVR	DEG_APCC_DBOX_1	0.7523
p.R349W	TCGA-VQ-A8PD	STAD	TCGA	RRISLRKVR	DEG_APCC_DBOX_1	0.7523
p.R349W	DO12124	GBM	ICGC	RRISLRKVR	DEG_APCC_DBOX_1	0.7523
p.R349W	DO51768	STAD	ICGC	RRISLRKVR	DEG_APCC_DBOX_1	0.7523
p.L364M	TCGA-95-7043	LUAD	TCGA	RRISLRKVR	DEG_APCC_DBOX_1	0.1389
p.L364M	DO24739	LUAD	ICGC	RRISLRKVR	DEG_APCC_DBOX_1	0.1389
p.E367D	TCGA-A5-A2K5	UCEC	TCGA	RRISLRKVR	DEG_APCC_DBOX_1	0.0556
p.E367D	DO41379	UCEC	ICGC	RRISLRKVR	DEG_APCC_DBOX_1	0.0556
p.S363C	TCGA-AN-A0XR	BRCA	TCGA	RRISLRKVR	DEG_APCC_DBOX_1	0.1667
p.S363C	DO3412	BRCA	ICGC	RRISLRKVR	DEG_APCC_DBOX_1	0.1667
p.P348Q	TCGA-BF-A5EO	SKCM	TCGA	RRISLRKVR	DEG_APCC_DBOX_1	0.3056
p.P348Q	DO219450	SKCM	ICGC	RRISLRKVR	DEG_APCC_DBOX_1	0.3056
p.A366V	TCGA-DI-A1BU	UCEC	TCGA	RRISLRKVR	DEG_APCC_DBOX_1	0.0833
p.A366V	DO42023	UCEC	ICGC	RRISLRKVR	DEG_APCC_DBOX_1	0.0833
p.R339C	TCGA-EB-A41B	SKCM	TCGA	RRISLRKVR	DEG_APCC_DBOX_1	0.0556
p.R339C	DO37611	SKCM	ICGC	RRISLRKVR	DEG_APCC_DBOX_1	0.0556
p.R350W	TCGA-FI-A2D5	UCEC	TCGA	RRISLRKVR	DEG_APCC_DBOX_1	0.8634
p.R350W	DO41331	UCEC	ICGC	RRISLRKVR	DEG_APCC_DBOX_1	0.8634
p.E362K	DO48396	BLCA	ICGC	RRISLRKVR	DEG_APCC_DBOX_1	0.1944
p.R357P	DO222404	BTCA	ICGC	RRISLRKVR	DEG_APCC_DBOX_1	0.6401
p.A361D	DO27901	ORCA	ICGC	RRISLRKVR	DEG_APCC_DBOX_1	0.2222
p.R339H	DO49424	PACA	ICGC	RRISLRKVR	DEG_APCC_DBOX_1	0.0556
p.R357W	DO232761	PBCA	ICGC	RRISLRKVR	DEG_APCC_DBOX_1	0.7523
p.T360P	ACH-000499	Bone Cancer	CCLE	RRISLRKVR	DEG_APCC_DBOX_1	0.6944
p.T360P	ACH-002194	Bone Cancer	CCLE	RRISLRKVR	DEG_APCC_DBOX_1	0.6944
p.T360P	RH-1	soft_tissue	COSMIC	RRISLRKVR	DEG_APCC_DBOX_1	0.6944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: RRISLRKVR

Degron related mutations and impact score

Drug responses associated with IQSEC3 mutations

All proteins holding degron of RRISLRKVR

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UPP2	IQ motif and SEC7 domain-containing protein 3	DEG_APCC_DBOX_1	349:357	RRISLRKVR	APC,CDC20,FZR1	0.976	More...