DegronMD

Uniprot ID: Q9UPP2

Source protein: IQ motif and SEC7 domain-containing protein 3

Source gene: IQSEC3

Class: LIG_APCC_ABBA_1

Location: 895:900

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5823

ASA_SCORE: 49.25

COIL: 0.3132

CONS_SCORE: 0.5903

DSS_SCORE: 0.0136

HELIX: 0.4578

FCONS_SCORE: 1.2155

RIG_SCORE: 0.9884

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L901M	TCGA-B5-A11E	UCEC	TCGA	VFLFND	LIG_APCC_ABBA_1	0.3056
p.L901M	DO41644	UCEC	ICGC	VFLFND	LIG_APCC_ABBA_1	0.3056
p.Q888H	TCGA-CM-6171	COAD	TCGA	VFLFND	LIG_APCC_ABBA_1	0.1389
p.Q888H	DO8151	COAD	ICGC	VFLFND	LIG_APCC_ABBA_1	0.1389
p.A890T	TCGA-DI-A1BU	UCEC	TCGA	VFLFND	LIG_APCC_ABBA_1	0.1944
p.A890T	DO42023	UCEC	ICGC	VFLFND	LIG_APCC_ABBA_1	0.1944
p.P909L	TCGA-EJ-A7NF	PRAD	TCGA	VFLFND	LIG_APCC_ABBA_1	0.0833
p.P909L	DO10806	EOPC	ICGC	VFLFND	LIG_APCC_ABBA_1	0.0833
p.P909L	DO51321	PRAD	ICGC	VFLFND	LIG_APCC_ABBA_1	0.0833
p.F898L	TCGA-UY-A78P	BLCA	TCGA	VFLFND	LIG_APCC_ABBA_1	0.6981
p.F898L	DO219036	BLCA	ICGC	VFLFND	LIG_APCC_ABBA_1	0.6981
p.H891Q	DO233767	GACA	ICGC	VFLFND	LIG_APCC_ABBA_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UPP2	IQ motif and SEC7 domain-containing protein 3	LIG_APCC_ABBA_1	895:900	VFLFND	APC,CDC20,FZR1	0.5823	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons