DegronMD - Q9NZ81(PRR13)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.K107N	TCGA-AX-A2HC	UCEC	TCGA	LAPGMVGPAVIV	DEG_ODPH_VHL_1	94:105	Mutation rewiring degron network	0.2778
p.P83L	TCGA-BG-A222	UCEC	TCGA	PPPY	ITCH	78:81	Mutation rewiring degron network	0.2778
p.P83L	DO42977	UCEC	ICGC	PPPY	ITCH	78:81	Mutation rewiring degron network	0.2778
p.P78S	TCGA-GN-A263	SKCM	TCGA	PPPY	ITCH	78:81	Mutation altering degron motif	0.6752
p.P78S	DO37766	SKCM	ICGC	PPPY	ITCH	78:81	Mutation altering degron motif	0.6752
p.M109I	DO231036	LUSC	ICGC	LAPGMVGPAVIV	DEG_ODPH_VHL_1	94:105	Mutation rewiring degron network	0.2222
p.P93S	DO220908	MELA	ICGC	LAPGMVGPAVIV	DEG_ODPH_VHL_1	94:105	Mutation rewiring degron network	0.3056
p.P89T	SIDM00216	Colorectal Carcinoma	GDSC	LAPGMVGPAVIV	DEG_ODPH_VHL_1	94:105	Mutation rewiring degron network	0.1944
p.P89T	SIDM00216	Colorectal Carcinoma	GDSC	PPPY	ITCH	78:81	Mutation rewiring degron network	0.1111
p.P89T	ACH-000989	Colon/Colorectal Cancer	CCLE	LAPGMVGPAVIV	DEG_ODPH_VHL_1	94:105	Mutation rewiring degron network	0.1944
p.P89T	ACH-000989	Colon/Colorectal Cancer	CCLE	PPPY	ITCH	78:81	Mutation rewiring degron network	0.1111
p.P89T	SNU-175	large intestine	COSMIC	LAPGMVGPAVIV	DEG_ODPH_VHL_1	94:105	Mutation rewiring degron network	0.1944
p.P89T	SNU-175	large intestine	COSMIC	PPPY	ITCH	78:81	Mutation rewiring degron network	0.1111
p.V103L	SIDM00181	Bladder Carcinoma	GDSC	LAPGMVGPAVIV	DEG_ODPH_VHL_1	94:105	Mutation altering degron motif	0.5654
p.V103L	SIDM01646	Non-Cancerous	GDSC	LAPGMVGPAVIV	DEG_ODPH_VHL_1	94:105	Mutation altering degron motif	0.5654
p.P101S	SIDM00954	Breast Carcinoma	GDSC	LAPGMVGPAVIV	DEG_ODPH_VHL_1	94:105	Mutation altering degron motif	0.5641
p.P101S	ACH-001820	Breast Cancer	CCLE	LAPGMVGPAVIV	DEG_ODPH_VHL_1	94:105	Mutation altering degron motif	0.5641
p.P101S	COLO-824	breast	COSMIC	LAPGMVGPAVIV	DEG_ODPH_VHL_1	94:105	Mutation altering degron motif	0.5641
p.I88L	SIDM00534	Colorectal Carcinoma	GDSC	LAPGMVGPAVIV	DEG_ODPH_VHL_1	94:105	Mutation rewiring degron network	0.1667
p.I88L	SIDM00534	Colorectal Carcinoma	GDSC	PPPY	ITCH	78:81	Mutation rewiring degron network	0.1389
p.I88L	ACH-000986	Colon/Colorectal Cancer	CCLE	LAPGMVGPAVIV	DEG_ODPH_VHL_1	94:105	Mutation rewiring degron network	0.1667
p.I88L	ACH-000986	Colon/Colorectal Cancer	CCLE	PPPY	ITCH	78:81	Mutation rewiring degron network	0.1389
p.I88L	HT-115	large intestine	COSMIC	LAPGMVGPAVIV	DEG_ODPH_VHL_1	94:105	Mutation rewiring degron network	0.1667
p.I88L	HT-115	large intestine	COSMIC	PPPY	ITCH	78:81	Mutation rewiring degron network	0.1389
p.P86L	SIDM01588	Endometrial Carcinoma	GDSC	LAPGMVGPAVIV	DEG_ODPH_VHL_1	94:105	Mutation rewiring degron network	0.1111
p.P86L	SIDM01588	Endometrial Carcinoma	GDSC	PPPY	ITCH	78:81	Mutation rewiring degron network	0.1944
p.P86L	ACH-000993	Endometrial/Uterine Cancer	CCLE	LAPGMVGPAVIV	DEG_ODPH_VHL_1	94:105	Mutation rewiring degron network	0.1111
p.P86L	ACH-000993	Endometrial/Uterine Cancer	CCLE	PPPY	ITCH	78:81	Mutation rewiring degron network	0.1944
p.K111N	ACH-000923	Lymphoma	CCLE	LAPGMVGPAVIV	DEG_ODPH_VHL_1	94:105	Mutation substituting flanking lysine	0.2778
p.A102T	ACH-002647	Gastric Cancer	CCLE	LAPGMVGPAVIV	DEG_ODPH_VHL_1	94:105	Mutation altering degron motif	0.6028
p.S109F	EJM	haematopoietic and lymphoid tissue	COSMIC	LAPGMVGPAVIV	DEG_ODPH_VHL_1	94:105	Mutation rewiring degron network	0.2222
p.K86T	SNU-81	large intestine	COSMIC	LAPGMVGPAVIV	DEG_ODPH_VHL_1	94:105	Mutation rewiring degron network	0.1111
p.K86T	SNU-81	large intestine	COSMIC	PPPY	ITCH	78:81	Mutation rewiring degron network	0.1944
p.P69S	COLO-824	breast	COSMIC	PPPY	ITCH	78:81	Mutation rewiring degron network	0.0833
p.K68T	SNU-81	large intestine	COSMIC	PPPY	ITCH	78:81	Mutation rewiring degron network	0.0556
p.P103T	SNU-175	large intestine	COSMIC	LAPGMVGPAVIV	DEG_ODPH_VHL_1	94:105	Mutation altering degron motif	0.7031
p.S88C	EJM	haematopoietic and lymphoid tissue	COSMIC	LAPGMVGPAVIV	DEG_ODPH_VHL_1	94:105	Mutation rewiring degron network	0.1667
p.S88C	EJM	haematopoietic and lymphoid tissue	COSMIC	PPPY	ITCH	78:81	Mutation rewiring degron network	0.1389
p.S108F	EJM	haematopoietic and lymphoid tissue	COSMIC	LAPGMVGPAVIV	DEG_ODPH_VHL_1	94:105	Mutation substituting flanking lysine	0.3611
p.S91F	EJM	haematopoietic and lymphoid tissue	COSMIC	LAPGMVGPAVIV	DEG_ODPH_VHL_1	94:105	Mutation rewiring degron network	0.25
p.S91F	EJM	haematopoietic and lymphoid tissue	COSMIC	PPPY	ITCH	78:81	Mutation rewiring degron network	0.0556
p.Y79H	RH-1	soft tissue	COSMIC	PPPY	ITCH	78:81	Mutation altering degron motif	0.7229
p.S106C	EJM	haematopoietic and lymphoid tissue	COSMIC	LAPGMVGPAVIV	DEG_ODPH_VHL_1	94:105	Mutation rewiring degron network	0.3056
p.S90F	EJM	haematopoietic and lymphoid tissue	COSMIC	LAPGMVGPAVIV	DEG_ODPH_VHL_1	94:105	Mutation rewiring degron network	0.2222
p.S90F	EJM	haematopoietic and lymphoid tissue	COSMIC	PPPY	ITCH	78:81	Mutation rewiring degron network	0.0833
p.H75Y	EJM	haematopoietic and lymphoid tissue	COSMIC	PPPY	ITCH	78:81	Mutation rewiring degron network	0.25
p.Y97H	RH-1	soft tissue	COSMIC	LAPGMVGPAVIV	DEG_ODPH_VHL_1	94:105	Mutation altering degron motif	0.7229
p.P115S	COLO-824	breast	COSMIC	LAPGMVGPAVIV	DEG_ODPH_VHL_1	94:105	Mutation substituting flanking lysine	0.1667
p.I102L	HT-115	large intestine	COSMIC	LAPGMVGPAVIV	DEG_ODPH_VHL_1	94:105	Mutation altering degron motif	0.7174

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PRR13

UniProt ID: Q9NZ81

Entrez ID: 54458

Protein name: Proline-rich protein 13 (Taxane-resistance protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PRR13 in