DegronMD

Uniprot ID: Q9NZ81

Source protein: Proline-rich protein 13

Source gene: PRR13

Class: DEG_ODPH_VHL_1

Location: 94:105

E3 ligase: VHL

DEGRON score: 0.9126

ASA_SCORE: 46.2833

COIL: 0.7052

CONS_SCORE: 1

DSS_SCORE: 0.4816

HELIX: 0.114

FCONS_SCORE: 1

RIG_SCORE: 0.7142

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K107N	TCGA-AX-A2HC	UCEC	TCGA	LAPGMVGPAVIV	DEG_ODPH_VHL_1	0.2778
p.M109I	DO231036	LUSC	ICGC	LAPGMVGPAVIV	DEG_ODPH_VHL_1	0.2222
p.P93S	DO220908	MELA	ICGC	LAPGMVGPAVIV	DEG_ODPH_VHL_1	0.3056
p.P89T	SIDM00216	Colorectal Carcinoma	GDSC	LAPGMVGPAVIV	DEG_ODPH_VHL_1	0.1944
p.P89T	ACH-000989	Colon/Colorectal Cancer	CCLE	LAPGMVGPAVIV	DEG_ODPH_VHL_1	0.1944
p.P89T	SNU-175	large_intestine	COSMIC	LAPGMVGPAVIV	DEG_ODPH_VHL_1	0.1944
p.V103L	SIDM00181	Bladder Carcinoma	GDSC	LAPGMVGPAVIV	DEG_ODPH_VHL_1	0.5654
p.V103L	SIDM01646	Non-Cancerous	GDSC	LAPGMVGPAVIV	DEG_ODPH_VHL_1	0.5654
p.P101S	SIDM00954	Breast Carcinoma	GDSC	LAPGMVGPAVIV	DEG_ODPH_VHL_1	0.5641
p.P101S	ACH-001820	Breast Cancer	CCLE	LAPGMVGPAVIV	DEG_ODPH_VHL_1	0.5641
p.P101S	COLO-824	breast	COSMIC	LAPGMVGPAVIV	DEG_ODPH_VHL_1	0.5641
p.I88L	SIDM00534	Colorectal Carcinoma	GDSC	LAPGMVGPAVIV	DEG_ODPH_VHL_1	0.1667
p.I88L	ACH-000986	Colon/Colorectal Cancer	CCLE	LAPGMVGPAVIV	DEG_ODPH_VHL_1	0.1667
p.I88L	HT-115	large_intestine	COSMIC	LAPGMVGPAVIV	DEG_ODPH_VHL_1	0.1667
p.P86L	SIDM01588	Endometrial Carcinoma	GDSC	LAPGMVGPAVIV	DEG_ODPH_VHL_1	0.1111
p.P86L	ACH-000993	Endometrial/Uterine Cancer	CCLE	LAPGMVGPAVIV	DEG_ODPH_VHL_1	0.1111
p.K111N	ACH-000923	Lymphoma	CCLE	LAPGMVGPAVIV	DEG_ODPH_VHL_1	0.2778
p.A102T	ACH-002647	Gastric Cancer	CCLE	LAPGMVGPAVIV	DEG_ODPH_VHL_1	0.6028
p.S109F	EJM	haematopoietic_and_lymphoid_tissue	COSMIC	LAPGMVGPAVIV	DEG_ODPH_VHL_1	0.2222
p.K86T	SNU-81	large_intestine	COSMIC	LAPGMVGPAVIV	DEG_ODPH_VHL_1	0.1111
p.P103T	SNU-175	large_intestine	COSMIC	LAPGMVGPAVIV	DEG_ODPH_VHL_1	0.7031
p.S88C	EJM	haematopoietic_and_lymphoid_tissue	COSMIC	LAPGMVGPAVIV	DEG_ODPH_VHL_1	0.1667
p.S108F	EJM	haematopoietic_and_lymphoid_tissue	COSMIC	LAPGMVGPAVIV	DEG_ODPH_VHL_1	0.3611
p.S91F	EJM	haematopoietic_and_lymphoid_tissue	COSMIC	LAPGMVGPAVIV	DEG_ODPH_VHL_1	0.25
p.S106C	EJM	haematopoietic_and_lymphoid_tissue	COSMIC	LAPGMVGPAVIV	DEG_ODPH_VHL_1	0.3056
p.S90F	EJM	haematopoietic_and_lymphoid_tissue	COSMIC	LAPGMVGPAVIV	DEG_ODPH_VHL_1	0.2222
p.Y97H	RH-1	soft_tissue	COSMIC	LAPGMVGPAVIV	DEG_ODPH_VHL_1	0.7229
p.P115S	COLO-824	breast	COSMIC	LAPGMVGPAVIV	DEG_ODPH_VHL_1	0.1667
p.I102L	HT-115	large_intestine	COSMIC	LAPGMVGPAVIV	DEG_ODPH_VHL_1	0.7174

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LAPGMVGPAVIV

Degron related mutations and impact score

Drug responses associated with PRR13 mutations

All proteins holding degron of LAPGMVGPAVIV

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NZ81	Proline-rich protein 13	DEG_ODPH_VHL_1	94:105	LAPGMVGPAVIV	VHL	0.9126	More...