DegronMD - Q6UXU6(TMEM92)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G130S	TCGA-13-1507	OV	TCGA	PPPY	ITCH	117:120	Mutation rewiring degron network	0.0556
p.G130S	TCGA-13-1507	OV	TCGA	PPPY	ITCH	137:140	Mutation rewiring degron network	0.1389
p.G130S	DO27991	OV	ICGC	PPPY	ITCH	117:120	Mutation rewiring degron network	0.0556
p.G130S	DO27991	OV	ICGC	PPPY	ITCH	137:140	Mutation rewiring degron network	0.1389
p.P136Q	TCGA-AJ-A3BH	UCEC	TCGA	PPPY	ITCH	137:140	Mutation rewiring degron network	0.3056
p.P136Q	DO41638	UCEC	ICGC	PPPY	ITCH	137:140	Mutation rewiring degron network	0.3056
p.D150N	TCGA-BF-AAP2	SKCM	TCGA	PPPY	ITCH	137:140	Mutation rewiring degron network	0.0556
p.D150N	DO219466	SKCM	ICGC	PPPY	ITCH	137:140	Mutation rewiring degron network	0.0556
p.T134P	TCGA-BS-A0TI	UCEC	TCGA	PPPY	ITCH	137:140	Mutation rewiring degron network	0.25
p.T134P	DO41608	UCEC	ICGC	PPPY	ITCH	137:140	Mutation rewiring degron network	0.25
p.E135K	TCGA-D6-6516	HNSC	TCGA	PPPY	ITCH	137:140	Mutation rewiring degron network	0.2778
p.E135K	DO15623	HNSC	ICGC	PPPY	ITCH	137:140	Mutation rewiring degron network	0.2778
p.V111L	TCGA-DF-A2KU	UCEC	TCGA	PPPY	ITCH	117:120	Mutation rewiring degron network	0.1667
p.V111L	DO223286	UCEC	ICGC	PPPY	ITCH	117:120	Mutation rewiring degron network	0.1667
p.E107D	TCGA-E7-A541	BLCA	TCGA	PPPY	ITCH	117:120	Mutation rewiring degron network	0.0556
p.E107D	DO44037	BLCA	ICGC	PPPY	ITCH	117:120	Mutation rewiring degron network	0.0556
p.P133T	TCGA-OD-A75X	SKCM	TCGA	PPPY	ITCH	137:140	Mutation rewiring degron network	0.2222
p.P133T	DO48601	SKCM	ICGC	PPPY	ITCH	137:140	Mutation rewiring degron network	0.2222
p.K126M	TCGA-RC-A7SK	LIHC	TCGA	PPPY	ITCH	117:120	Mutation substituting flanking lysine	0.2778
p.K126M	DO52314	LIHC	ICGC	PPPY	ITCH	117:120	Mutation substituting flanking lysine	0.2778
p.R108K	TCGA-W3-AA1R	SKCM	TCGA	PPPY	ITCH	117:120	Mutation rewiring degron network	0.0833
p.R108K	DO51275	SKCM	ICGC	PPPY	ITCH	117:120	Mutation rewiring degron network	0.0833
p.Y140C	DO233226	GACA	ICGC	PPPY	ITCH	137:140	Mutation altering degron motif	0.7087
p.R108S	DO228986	LICA	ICGC	PPPY	ITCH	117:120	Mutation rewiring degron network	0.0833
p.P119L	SIDM00189	Melanoma	GDSC	PPPY	ITCH	117:120	Mutation altering degron motif	0.6471
p.P119L	ACH-002098	Skin Cancer	CCLE	PPPY	ITCH	117:120	Mutation altering degron motif	0.6471
p.P119L	CP67-MEL	skin	COSMIC	PPPY	ITCH	117:120	Mutation altering degron motif	0.6471
p.E145K	SIDM01093	Cervical Carcinoma	GDSC	PPPY	ITCH	137:140	Mutation rewiring degron network	0.1944
p.E145K	ACH-000556	Cervical Cancer	CCLE	PPPY	ITCH	137:140	Mutation rewiring degron network	0.1944
p.E145K	SiHa	cervix	COSMIC	PPPY	ITCH	137:140	Mutation rewiring degron network	0.1944
p.P137L	SIDM01121	Small Cell Lung Carcinoma	GDSC	PPPY	ITCH	137:140	Mutation altering degron motif	0.7582
p.P137L	ACH-000358	Lung Cancer	CCLE	PPPY	ITCH	137:140	Mutation altering degron motif	0.7582
p.P137L	NCI-H69	lung	COSMIC	PPPY	ITCH	137:140	Mutation altering degron motif	0.7582
p.A115V	SIDM01617	Endometrial Carcinoma	GDSC	PPPY	ITCH	117:120	Mutation rewiring degron network	0.2778
p.A115V	ACH-000994	Endometrial/Uterine Cancer	CCLE	PPPY	ITCH	117:120	Mutation rewiring degron network	0.2778
p.R143S	ACH-000901	Lung Cancer	CCLE	PPPY	ITCH	137:140	Mutation rewiring degron network	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TMEM92

UniProt ID: Q6UXU6

Entrez ID: 162461

Protein name: Transmembrane protein 92

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TMEM92 in