DegronMD - Q92567(FAM168A)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Y29C	TCGA-85-8355	LUSC	TCGA	NPKNMAYTGYP	CBL_PTK	16:26	Mutation rewiring degron network	0.25
p.Y29C	DO45488	LUSC	ICGC	NPKNMAYTGYP	CBL_PTK	16:26	Mutation rewiring degron network	0.25
p.T23M	TCGA-A5-A0G2	UCEC	TCGA	NPKNMAYTGYP	CBL_PTK	16:26	Mutation altering degron motif	0.8534
p.T23M	DO41235	UCEC	ICGC	NPKNMAYTGYP	CBL_PTK	16:26	Mutation altering degron motif	0.8534
p.A209V	TCGA-B5-A3FA	UCEC	TCGA	LLTTPQHT	DEG_SCF_FBW7_1	210:217	Mutation rewiring degron network	0.3056
p.P116Q	TCGA-CV-7415	HNSC	TCGA	NTAPPPYSPSP	CBL_PTK	117:127	Mutation rewiring degron network	0.3056
p.P116Q	TCGA-CV-7415	HNSC	TCGA	PPPY	ITCH	120:123	Mutation rewiring degron network	0.2222
p.Y36F	TCGA-DD-AACZ	LIHC	TCGA	NPKNMAYTGYP	CBL_PTK	16:26	Mutation rewiring degron network	0.0556
p.Y36F	DO52216	LIHC	ICGC	NPKNMAYTGYP	CBL_PTK	16:26	Mutation rewiring degron network	0.0556
p.I128M	TCGA-EK-A2RJ	CESC	TCGA	NTAPPPYSPSP	CBL_PTK	117:127	Mutation rewiring degron network	0.3056
p.I128M	TCGA-EK-A2RJ	CESC	TCGA	PPPY	ITCH	120:123	Mutation rewiring degron network	0.1944
p.I137M	DO49950	CESC	ICGC	NTAPPPYSPSP	CBL_PTK	117:127	Mutation rewiring degron network	0.0556
p.P125Q	DO14926	HNSC	ICGC	NTAPPPYSPSP	CBL_PTK	117:127	Mutation altering degron motif	0.5924
p.A227E	DO228938	LICA	ICGC	LLTTPQHT	DEG_SCF_FBW7_1	210:217	Mutation rewiring degron network	0.0556
p.N16K	DO229028	LICA	ICGC	NPKNMAYTGYP	CBL_PTK	16:26	Mutation altering degron motif	0.6918
p.P126T	DO229026	LICA	ICGC	NTAPPPYSPSP	CBL_PTK	117:127	Mutation altering degron motif	0.7031
p.M205I	DO229026	LICA	ICGC	LLTTPQHT	DEG_SCF_FBW7_1	210:217	Mutation rewiring degron network	0.1944
p.P108Q	DO229045	LICA	ICGC	NTAPPPYSPSP	CBL_PTK	117:127	Mutation rewiring degron network	0.0833
p.P7T	DO229009	LICA	ICGC	NPKNMAYTGYP	CBL_PTK	16:26	Mutation rewiring degron network	0.0833
p.P30S	DO222395	MELA	ICGC	NPKNMAYTGYP	CBL_PTK	16:26	Mutation rewiring degron network	0.2222
p.A227V	DO232761	PBCA	ICGC	LLTTPQHT	DEG_SCF_FBW7_1	210:217	Mutation rewiring degron network	0.0556
p.P113L	DO36397	READ	ICGC	NTAPPPYSPSP	CBL_PTK	117:127	Mutation rewiring degron network	0.2222
p.P113L	DO36397	READ	ICGC	PPPY	ITCH	120:123	Mutation rewiring degron network	0.1389
p.Y25S	DO219881	SKCA	ICGC	NPKNMAYTGYP	CBL_PTK	16:26	Mutation altering degron motif	0.6009
p.Y25S	DO229453	SKCA	ICGC	NPKNMAYTGYP	CBL_PTK	16:26	Mutation altering degron motif	0.6009
p.Y25S	DO227681	SKCA	ICGC	NPKNMAYTGYP	CBL_PTK	16:26	Mutation altering degron motif	0.6009
p.K110N	DO47578	SKCM	ICGC	NTAPPPYSPSP	CBL_PTK	117:127	Mutation substituting flanking lysine	0.25
p.K110N	DO47578	SKCM	ICGC	PPPY	ITCH	120:123	Mutation substituting flanking lysine	0.1667
p.V125M	DO42264	UCEC	ICGC	NTAPPPYSPSP	CBL_PTK	117:127	Mutation altering degron motif	0.7208
p.A33V	SIDM00633	Breast Carcinoma	GDSC	NPKNMAYTGYP	CBL_PTK	16:26	Mutation rewiring degron network	0.1389
p.A33V	MDA-MB-175-VII	breast	COSMIC	NPKNMAYTGYP	CBL_PTK	16:26	Mutation rewiring degron network	0.1389
p.G220E	SIDM01045	Endometrial Carcinoma	GDSC	LLTTPQHT	DEG_SCF_FBW7_1	210:217	Mutation rewiring degron network	0.25
p.G220E	EN	endometrium	COSMIC	LLTTPQHT	DEG_SCF_FBW7_1	210:217	Mutation rewiring degron network	0.25
p.T219A	ACH-000339	Lung Cancer	CCLE	LLTTPQHT	DEG_SCF_FBW7_1	210:217	Mutation rewiring degron network	0.2778
p.R221M	ACH-000851	Lung Cancer	CCLE	LLTTPQHT	DEG_SCF_FBW7_1	210:217	Mutation rewiring degron network	0.2222
p.G211E	ACH-000978	Endometrial/Uterine Cancer	CCLE	LLTTPQHT	DEG_SCF_FBW7_1	210:217	Mutation altering degron motif	0.7199
p.G211E	EN	endometrium	COSMIC	LLTTPQHT	DEG_SCF_FBW7_1	210:217	Mutation altering degron motif	0.7199
p.T225I	ACH-001399	Colon/Colorectal Cancer	CCLE	LLTTPQHT	DEG_SCF_FBW7_1	210:217	Mutation rewiring degron network	0.1111
p.T225I	SW626	ovary	COSMIC	LLTTPQHT	DEG_SCF_FBW7_1	210:217	Mutation rewiring degron network	0.1111
p.T119I	SW626	ovary	COSMIC	NTAPPPYSPSP	CBL_PTK	117:127	Mutation altering degron motif	0.7078
p.Y124C	AN3-CA	endometrium	COSMIC	NTAPPPYSPSP	CBL_PTK	117:127	Mutation altering degron motif	0.7087

DegronMD: protein-targeted degradation, mutation and drug response to degrons

FAM168A

UniProt ID: Q92567

Entrez ID: 23201

Protein name: Protein FAM168A (Tongue cancer chemotherapy resistance-associated protein 1)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for FAM168A in