DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
NPKNMAYTGYP
Uniprot ID:
Q92567
Source protein:
Protein FAM168A
Source gene:
FAM168A
Class:
CBL_PTK
Location:
16:26
E3 ligase:
CBL
DEGRON score:
0.7815
ASA_SCORE:
48.6273
COIL:
0.7221
CONS_SCORE:
0.8401
DSS_SCORE:
0.2865
HELIX:
0.1095
FCONS_SCORE:
1.0026
RIG_SCORE:
0.7063
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.Y29C
TCGA-85-8355
LUSC
TCGA
NPKNMAYTGYP
CBL_PTK
0.25
p.Y29C
DO45488
LUSC
ICGC
NPKNMAYTGYP
CBL_PTK
0.25
p.T23M
TCGA-A5-A0G2
UCEC
TCGA
NPKNMAYTGYP
CBL_PTK
0.8534
p.T23M
DO41235
UCEC
ICGC
NPKNMAYTGYP
CBL_PTK
0.8534
p.Y36F
TCGA-DD-AACZ
LIHC
TCGA
NPKNMAYTGYP
CBL_PTK
0.0556
p.Y36F
DO52216
LIHC
ICGC
NPKNMAYTGYP
CBL_PTK
0.0556
p.N16K
DO229028
LICA
ICGC
NPKNMAYTGYP
CBL_PTK
0.6918
p.P7T
DO229009
LICA
ICGC
NPKNMAYTGYP
CBL_PTK
0.0833
p.P30S
DO222395
MELA
ICGC
NPKNMAYTGYP
CBL_PTK
0.2222
p.Y25S
DO219881
SKCA
ICGC
NPKNMAYTGYP
CBL_PTK
0.6009
p.Y25S
DO229453
SKCA
ICGC
NPKNMAYTGYP
CBL_PTK
0.6009
p.Y25S
DO227681
SKCA
ICGC
NPKNMAYTGYP
CBL_PTK
0.6009
p.A33V
SIDM00633
Breast Carcinoma
GDSC
NPKNMAYTGYP
CBL_PTK
0.1389
p.A33V
MDA-MB-175-VII
breast
COSMIC
NPKNMAYTGYP
CBL_PTK
0.1389
Drug responses associated with FAM168A mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of NPKNMAYTGYP
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q92567
Protein FAM168A
CBL_PTK
16:26
NPKNMAYTGYP
CBL
0.7815
More...
