DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
NTAPPPYSPSP
Uniprot ID:
Q92567
Source protein:
Protein FAM168A
Source gene:
FAM168A
Class:
CBL_PTK
Location:
117:127
E3 ligase:
CBL
DEGRON score:
0.8891
ASA_SCORE:
77.4
COIL:
0.9475
CONS_SCORE:
0.9174
DSS_SCORE:
0.639
HELIX:
0.0181
FCONS_SCORE:
0.9483
RIG_SCORE:
0.5789
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.P116Q
TCGA-CV-7415
HNSC
TCGA
NTAPPPYSPSP
CBL_PTK
0.3056
p.I128M
TCGA-EK-A2RJ
CESC
TCGA
NTAPPPYSPSP
CBL_PTK
0.3056
p.I137M
DO49950
CESC
ICGC
NTAPPPYSPSP
CBL_PTK
0.0556
p.P125Q
DO14926
HNSC
ICGC
NTAPPPYSPSP
CBL_PTK
0.5924
p.P126T
DO229026
LICA
ICGC
NTAPPPYSPSP
CBL_PTK
0.7031
p.P108Q
DO229045
LICA
ICGC
NTAPPPYSPSP
CBL_PTK
0.0833
p.P113L
DO36397
READ
ICGC
NTAPPPYSPSP
CBL_PTK
0.2222
p.K110N
DO47578
SKCM
ICGC
NTAPPPYSPSP
CBL_PTK
0.25
p.V125M
DO42264
UCEC
ICGC
NTAPPPYSPSP
CBL_PTK
0.7208
p.T119I
SW626
ovary
COSMIC
NTAPPPYSPSP
CBL_PTK
0.7078
p.Y124C
AN3-CA
endometrium
COSMIC
NTAPPPYSPSP
CBL_PTK
0.7087
Drug responses associated with FAM168A mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of NTAPPPYSPSP
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q92567
Protein FAM168A
CBL_PTK
117:127
NTAPPPYSPSP
CBL
0.8891
More...
