DegronMD

Uniprot ID: Q92567

Source protein: Protein FAM168A

Source gene: FAM168A

Class: DEG_SCF_FBW7_1

Location: 210:217

E3 ligase: FBXW7

DEGRON score: 0.9586

ASA_SCORE: 66.5

COIL: 0.7173

CONS_SCORE: 0.9788

DSS_SCORE: 0.4066

HELIX: 0.046

FCONS_SCORE: 1.0196

RIG_SCORE: 0.7543

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A209V	TCGA-B5-A3FA	UCEC	TCGA	LLTTPQHT	DEG_SCF_FBW7_1	0.3056
p.A227E	DO228938	LICA	ICGC	LLTTPQHT	DEG_SCF_FBW7_1	0.0556
p.M205I	DO229026	LICA	ICGC	LLTTPQHT	DEG_SCF_FBW7_1	0.1944
p.A227V	DO232761	PBCA	ICGC	LLTTPQHT	DEG_SCF_FBW7_1	0.0556
p.G220E	SIDM01045	Endometrial Carcinoma	GDSC	LLTTPQHT	DEG_SCF_FBW7_1	0.25
p.G220E	EN	endometrium	COSMIC	LLTTPQHT	DEG_SCF_FBW7_1	0.25
p.T219A	ACH-000339	Lung Cancer	CCLE	LLTTPQHT	DEG_SCF_FBW7_1	0.2778
p.R221M	ACH-000851	Lung Cancer	CCLE	LLTTPQHT	DEG_SCF_FBW7_1	0.2222
p.G211E	ACH-000978	Endometrial/Uterine Cancer	CCLE	LLTTPQHT	DEG_SCF_FBW7_1	0.7199
p.G211E	EN	endometrium	COSMIC	LLTTPQHT	DEG_SCF_FBW7_1	0.7199
p.T225I	ACH-001399	Colon/Colorectal Cancer	CCLE	LLTTPQHT	DEG_SCF_FBW7_1	0.1111
p.T225I	SW626	ovary	COSMIC	LLTTPQHT	DEG_SCF_FBW7_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q92567	Protein FAM168A	DEG_SCF_FBW7_1	210:217	LLTTPQHT	FBXW7	0.9586	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons