DegronMD - A4D263(SPATA48)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V313M	SIDM00128	Head and Neck Carcinoma	GDSC	VSSSS	DEG_SPOP_SBC_1	313:317	Mutation altering degron motif	0.7208
p.V313M	JHU-011	upper aerodigestive tract	COSMIC	VSSSS	DEG_SPOP_SBC_1	313:317	Mutation altering degron motif	0.7208
p.G89R	SIDM00297	Non-Small Cell Lung Carcinoma	GDSC	PPPY	ITCH	85:88	Mutation rewiring degron network	0.3056
p.G89R	LC-2-ad	lung	COSMIC	PPPY	ITCH	85:88	Mutation rewiring degron network	0.3056
p.F312V	SIDM00504	Glioma	GDSC	VSSSS	DEG_SPOP_SBC_1	313:317	Mutation rewiring degron network	0.3056
p.F312V	SIDM00025	Head and Neck Carcinoma	GDSC	VSSSS	DEG_SPOP_SBC_1	313:317	Mutation rewiring degron network	0.3056
p.F312V	SIDM01164	Glioma	GDSC	VSSSS	DEG_SPOP_SBC_1	313:317	Mutation rewiring degron network	0.3056
p.F312V	SIDM00542	Glioblastoma	GDSC	VSSSS	DEG_SPOP_SBC_1	313:317	Mutation rewiring degron network	0.3056
p.T326I	SIDM01007	T-Lymphoblastic Leukemia	GDSC	VSSSS	DEG_SPOP_SBC_1	313:317	Mutation rewiring degron network	0.0833
p.T326I	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	VSSSS	DEG_SPOP_SBC_1	313:317	Mutation rewiring degron network	0.0833
p.R202H	SIDM00104	Mesothelioma	GDSC	LQPHHE	LIG_APCC_ABBA_1	195:200	Mutation rewiring degron network	0.2778
p.R202H	H2369	pleura	COSMIC	LQPHHE	LIG_APCC_ABBA_1	195:200	Mutation rewiring degron network	0.2778
p.P87S	SIDM01263	T-Lymphoblastic Leukemia	GDSC	PPPY	ITCH	85:88	Mutation altering degron motif	0.5641
p.P87S	SIDM01016	T-Lymphoblastic Leukemia	GDSC	PPPY	ITCH	85:88	Mutation altering degron motif	0.5641
p.P87S	Jurkat	haematopoietic and lymphoid tissue	COSMIC	PPPY	ITCH	85:88	Mutation altering degron motif	0.5641
p.P85L	SIDM00753	Squamous Cell Lung Carcinoma	GDSC	PPPY	ITCH	85:88	Mutation altering degron motif	0.7582
p.P85L	NCI-H2023	lung	COSMIC	PPPY	ITCH	85:88	Mutation altering degron motif	0.7582
p.Q196R	SIDM00683	Prostate Carcinoma	GDSC	LQPHHE	LIG_APCC_ABBA_1	195:200	Mutation altering degron motif	0.6218
p.Q196R	LNCaP-Clone-FGC	prostate	COSMIC	LQPHHE	LIG_APCC_ABBA_1	195:200	Mutation altering degron motif	0.6218
p.Q196P	SIDM00527	Colorectal Carcinoma	GDSC	LQPHHE	LIG_APCC_ABBA_1	195:200	Mutation altering degron motif	0.5924
p.Q196P	SIDM00826	Colorectal Carcinoma	GDSC	LQPHHE	LIG_APCC_ABBA_1	195:200	Mutation altering degron motif	0.5924
p.Q196P	MDST8	large intestine	COSMIC	LQPHHE	LIG_APCC_ABBA_1	195:200	Mutation altering degron motif	0.5924
p.Q196P	COLO-205	large intestine	COSMIC	LQPHHE	LIG_APCC_ABBA_1	195:200	Mutation altering degron motif	0.5924
p.I322N	SIDM00537	Colorectal Carcinoma	GDSC	VSSSS	DEG_SPOP_SBC_1	313:317	Mutation rewiring degron network	0.1944
p.I322N	GP5d	large intestine	COSMIC	VSSSS	DEG_SPOP_SBC_1	313:317	Mutation rewiring degron network	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SPATA48

UniProt ID: A4D263

Entrez ID:

Protein name: Spermatogenesis-associated protein 48

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SPATA48 in