DegronMD

Uniprot ID: A4D263

Source protein: Spermatogenesis-associated protein 48

Source gene: SPATA48

Class: LIG_APCC_ABBA_1

Location: 195:200

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7091

ASA_SCORE: 97.9833

COIL: 0.9077

CONS_SCORE: 0.3476

DSS_SCORE: 0.4607

HELIX: 0.0543

FCONS_SCORE: 0.7278

RIG_SCORE: 0.665

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R202H	SIDM00104	Mesothelioma	GDSC	LQPHHE	LIG_APCC_ABBA_1	0.2778
p.R202H	H2369	pleura	COSMIC	LQPHHE	LIG_APCC_ABBA_1	0.2778
p.Q196R	SIDM00683	Prostate Carcinoma	GDSC	LQPHHE	LIG_APCC_ABBA_1	0.6218
p.Q196R	LNCaP-Clone-FGC	prostate	COSMIC	LQPHHE	LIG_APCC_ABBA_1	0.6218
p.Q196P	SIDM00527	Colorectal Carcinoma	GDSC	LQPHHE	LIG_APCC_ABBA_1	0.5924
p.Q196P	SIDM00826	Colorectal Carcinoma	GDSC	LQPHHE	LIG_APCC_ABBA_1	0.5924
p.Q196P	MDST8	large_intestine	COSMIC	LQPHHE	LIG_APCC_ABBA_1	0.5924
p.Q196P	COLO-205	large_intestine	COSMIC	LQPHHE	LIG_APCC_ABBA_1	0.5924

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A4D263	Spermatogenesis-associated protein 48	LIG_APCC_ABBA_1	195:200	LQPHHE	APC,CDC20,FZR1	0.7091	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons