DegronMD - Q9Y3C5(RNF11)

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GO - Molecular function (MF): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S54R	TCGA-22-5481	LUSC	TCGA	PTPSQT	DEG_SCF_FBW7_1	51:56	Mutation altering degron motif	0.7427
p.S54R	DO27160	LUSC	ICGC	PTPSQT	DEG_SCF_FBW7_1	51:56	Mutation altering degron motif	0.7427
p.R57W	TCGA-AP-A059	UCEC	TCGA	PTPSQT	DEG_SCF_FBW7_1	51:56	Mutation rewiring degron network	0.3056
p.R57W	DO41361	UCEC	ICGC	PTPSQT	DEG_SCF_FBW7_1	51:56	Mutation rewiring degron network	0.3056
p.E42Q	TCGA-CV-7242	HNSC	TCGA	PTPSQT	DEG_SCF_FBW7_1	51:56	Mutation rewiring degron network	0.0833
p.E42Q	TCGA-CV-7242	HNSC	TCGA	PPPY	ITCH	37:40	Mutation rewiring degron network	0.2778
p.E42Q	DO14974	HNSC	ICGC	PTPSQT	DEG_SCF_FBW7_1	51:56	Mutation rewiring degron network	0.0833
p.E42Q	DO14974	HNSC	ICGC	PPPY	ITCH	37:40	Mutation rewiring degron network	0.2778
p.E31D	DO228978	LICA	ICGC	PPPY	ITCH	37:40	Mutation rewiring degron network	0.1667
p.T56A	SIDM00537	Colorectal Carcinoma	GDSC	PTPSQT	DEG_SCF_FBW7_1	51:56	Mutation altering degron motif	0.7139
p.T56A	ACH-000982	Colon/Colorectal Cancer	CCLE	PTPSQT	DEG_SCF_FBW7_1	51:56	Mutation altering degron motif	0.7139
p.T56A	ACH-001345	Colon/Colorectal Cancer	CCLE	PTPSQT	DEG_SCF_FBW7_1	51:56	Mutation altering degron motif	0.7139
p.T56A	GP5d	large intestine	COSMIC	PTPSQT	DEG_SCF_FBW7_1	51:56	Mutation altering degron motif	0.7139
p.P39S	SIDM00217	Colorectal Carcinoma	GDSC	PPPY	ITCH	37:40	Mutation altering degron motif	0.5641
p.P39S	ACH-000999	Colon/Colorectal Cancer	CCLE	PPPY	ITCH	37:40	Mutation altering degron motif	0.5641

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons