DegronMD

Uniprot ID: Q9Y3C5

Source protein: RING finger protein 11

Source gene: RNF11

Class: DEG_SCF_FBW7_1

Location: 51:56

E3 ligase: FBXW7

DEGRON score: 0.9857

ASA_SCORE: 60.35

COIL: 0.6977

CONS_SCORE: 0.5188

DSS_SCORE: 0.6267

HELIX: 0.2775

FCONS_SCORE: 0.9857

RIG_SCORE: 0.6824

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S54R	TCGA-22-5481	LUSC	TCGA	PTPSQT	DEG_SCF_FBW7_1	0.7427
p.S54R	DO27160	LUSC	ICGC	PTPSQT	DEG_SCF_FBW7_1	0.7427
p.R57W	TCGA-AP-A059	UCEC	TCGA	PTPSQT	DEG_SCF_FBW7_1	0.3056
p.R57W	DO41361	UCEC	ICGC	PTPSQT	DEG_SCF_FBW7_1	0.3056
p.E42Q	TCGA-CV-7242	HNSC	TCGA	PTPSQT	DEG_SCF_FBW7_1	0.0833
p.E42Q	DO14974	HNSC	ICGC	PTPSQT	DEG_SCF_FBW7_1	0.0833
p.T56A	SIDM00537	Colorectal Carcinoma	GDSC	PTPSQT	DEG_SCF_FBW7_1	0.7139
p.T56A	ACH-000982	Colon/Colorectal Cancer	CCLE	PTPSQT	DEG_SCF_FBW7_1	0.7139
p.T56A	ACH-001345	Colon/Colorectal Cancer	CCLE	PTPSQT	DEG_SCF_FBW7_1	0.7139
p.T56A	GP5d	large_intestine	COSMIC	PTPSQT	DEG_SCF_FBW7_1	0.7139

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y3C5	RING finger protein 11	DEG_SCF_FBW7_1	51:56	PTPSQT	FBXW7	0.9857	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons