DegronMD - Q7L0R7(RNF44)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A389V	TCGA-A5-A1OF	UCEC	TCGA	ARQLLRVLP	DEG_APCC_DBOX_1	389:397	Mutation altering degron motif	0.5825
p.A389V	TCGA-D1-A163	UCEC	TCGA	ARQLLRVLP	DEG_APCC_DBOX_1	389:397	Mutation altering degron motif	0.5825
p.A389V	DO41008	UCEC	ICGC	ARQLLRVLP	DEG_APCC_DBOX_1	389:397	Mutation altering degron motif	0.5825
p.A389V	DO42568	UCEC	ICGC	ARQLLRVLP	DEG_APCC_DBOX_1	389:397	Mutation altering degron motif	0.5825
p.A389V	SIDM00461	Acute Myeloid Leukemia	GDSC	ARQLLRVLP	DEG_APCC_DBOX_1	389:397	Mutation altering degron motif	0.5825
p.F387L	TCGA-AJ-A5DW	UCEC	TCGA	ARQLLRVLP	DEG_APCC_DBOX_1	389:397	Mutation rewiring degron network	0.2778
p.F387L	DO50075	UCEC	ICGC	ARQLLRVLP	DEG_APCC_DBOX_1	389:397	Mutation rewiring degron network	0.2778
p.R212W	TCGA-AP-A0LM	UCEC	TCGA	PRMPLQRLD	DEG_APCC_DBOX_1	211:219	Mutation altering degron motif	0.8634
p.R212W	DO43306	UCEC	ICGC	PRMPLQRLD	DEG_APCC_DBOX_1	211:219	Mutation altering degron motif	0.8634
p.R390W	TCGA-B5-A11E	UCEC	TCGA	ARQLLRVLP	DEG_APCC_DBOX_1	389:397	Mutation altering degron motif	0.8634
p.R390W	DO41644	UCEC	ICGC	ARQLLRVLP	DEG_APCC_DBOX_1	389:397	Mutation altering degron motif	0.8634
p.R390W	SIDM00365	Small Cell Lung Carcinoma	GDSC	ARQLLRVLP	DEG_APCC_DBOX_1	389:397	Mutation altering degron motif	0.8634
p.R390W	ACH-002196	Lung Cancer	CCLE	ARQLLRVLP	DEG_APCC_DBOX_1	389:397	Mutation altering degron motif	0.8634
p.R390W	SBC-1	lung	COSMIC	ARQLLRVLP	DEG_APCC_DBOX_1	389:397	Mutation altering degron motif	0.8634
p.R394Q	TCGA-D1-A15X	UCEC	TCGA	ARQLLRVLP	DEG_APCC_DBOX_1	389:397	Mutation altering degron motif	0.6218
p.R394Q	DO43274	UCEC	ICGC	ARQLLRVLP	DEG_APCC_DBOX_1	389:397	Mutation altering degron motif	0.6218
p.V407F	TCGA-VQ-AA64	STAD	TCGA	ARQLLRVLP	DEG_APCC_DBOX_1	389:397	Mutation rewiring degron network	0.0556
p.V407F	DO222381	STAD	ICGC	ARQLLRVLP	DEG_APCC_DBOX_1	389:397	Mutation rewiring degron network	0.0556
p.S310L	DO233204	GACA	ICGC	PPPY	ITCH	297:300	Mutation rewiring degron network	0.0556
p.P287Q	DO229036	LICA	ICGC	PPPY	ITCH	297:300	Mutation rewiring degron network	0.0556
p.A389T	DO50921	LICA	ICGC	ARQLLRVLP	DEG_APCC_DBOX_1	389:397	Mutation altering degron motif	0.6028
p.L396P	DO229248	THCA	ICGC	ARQLLRVLP	DEG_APCC_DBOX_1	389:397	Mutation altering degron motif	0.7582
p.L218F	SIDM01004	Chronic Myelogenous Leukemia	GDSC	PRMPLQRLD	DEG_APCC_DBOX_1	211:219	Mutation altering degron motif	0.6981
p.L218F	ACH-000983	Leukemia	CCLE	PRMPLQRLD	DEG_APCC_DBOX_1	211:219	Mutation altering degron motif	0.6981
p.S385G	SIDM00596	Endometrial Carcinoma	GDSC	ARQLLRVLP	DEG_APCC_DBOX_1	389:397	Mutation rewiring degron network	0.2222
p.S385G	ACH-001517	Endometrial/Uterine Cancer	CCLE	ARQLLRVLP	DEG_APCC_DBOX_1	389:397	Mutation rewiring degron network	0.2222
p.S385G	HEC-1	endometrium	COSMIC	ARQLLRVLP	DEG_APCC_DBOX_1	389:397	Mutation rewiring degron network	0.2222
p.L215F	SIDM01088	Endometrial Carcinoma	GDSC	PRMPLQRLD	DEG_APCC_DBOX_1	211:219	Mutation altering degron motif	0.6981
p.L215F	ACH-000965	Endometrial/Uterine Cancer	CCLE	PRMPLQRLD	DEG_APCC_DBOX_1	211:219	Mutation altering degron motif	0.6981
p.P290Q	ACH-000979	Prostate Cancer	CCLE	PPPY	ITCH	297:300	Mutation rewiring degron network	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RNF44

UniProt ID: Q7L0R7

Entrez ID: 22838

Protein name: RING finger protein 44

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for RNF44 in