DegronMD

Uniprot ID: Q7L0R7

Source protein: RING finger protein 44

Source gene: RNF44

Class: DEG_APCC_DBOX_1

Location: 211:219

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5822

ASA_SCORE: 102

COIL: 0.8547

CONS_SCORE: 0.3511

DSS_SCORE: 0.6609

HELIX: 0.1186

FCONS_SCORE: 0.9268

RIG_SCORE: 0.7306

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R212W	TCGA-AP-A0LM	UCEC	TCGA	PRMPLQRLD	DEG_APCC_DBOX_1	0.8634
p.R212W	DO43306	UCEC	ICGC	PRMPLQRLD	DEG_APCC_DBOX_1	0.8634
p.L218F	SIDM01004	Chronic Myelogenous Leukemia	GDSC	PRMPLQRLD	DEG_APCC_DBOX_1	0.6981
p.L218F	ACH-000983	Leukemia	CCLE	PRMPLQRLD	DEG_APCC_DBOX_1	0.6981
p.L215F	SIDM01088	Endometrial Carcinoma	GDSC	PRMPLQRLD	DEG_APCC_DBOX_1	0.6981
p.L215F	ACH-000965	Endometrial/Uterine Cancer	CCLE	PRMPLQRLD	DEG_APCC_DBOX_1	0.6981

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q7L0R7	RING finger protein 44	DEG_APCC_DBOX_1	211:219	PRMPLQRLD	APC,CDC20,FZR1	0.5822	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons