DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
ARQLLRVLP
Uniprot ID:
Q7L0R7
Source protein:
RING finger protein 44
Source gene:
RNF44
Class:
DEG_APCC_DBOX_1
Location:
389:397
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.5208
ASA_SCORE:
63.4444
COIL:
0.4394
CONS_SCORE:
0.5203
DSS_SCORE:
0.0171
HELIX:
0.0139
FCONS_SCORE:
0.77
RIG_SCORE:
0.8915
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.A389V
TCGA-A5-A1OF
UCEC
TCGA
ARQLLRVLP
DEG_APCC_DBOX_1
0.5825
p.A389V
TCGA-D1-A163
UCEC
TCGA
ARQLLRVLP
DEG_APCC_DBOX_1
0.5825
p.A389V
DO41008
UCEC
ICGC
ARQLLRVLP
DEG_APCC_DBOX_1
0.5825
p.A389V
DO42568
UCEC
ICGC
ARQLLRVLP
DEG_APCC_DBOX_1
0.5825
p.A389V
SIDM00461
Acute Myeloid Leukemia
GDSC
ARQLLRVLP
DEG_APCC_DBOX_1
0.5825
p.F387L
TCGA-AJ-A5DW
UCEC
TCGA
ARQLLRVLP
DEG_APCC_DBOX_1
0.2778
p.F387L
DO50075
UCEC
ICGC
ARQLLRVLP
DEG_APCC_DBOX_1
0.2778
p.R390W
TCGA-B5-A11E
UCEC
TCGA
ARQLLRVLP
DEG_APCC_DBOX_1
0.8634
p.R390W
DO41644
UCEC
ICGC
ARQLLRVLP
DEG_APCC_DBOX_1
0.8634
p.R390W
SIDM00365
Small Cell Lung Carcinoma
GDSC
ARQLLRVLP
DEG_APCC_DBOX_1
0.8634
p.R390W
ACH-002196
Lung Cancer
CCLE
ARQLLRVLP
DEG_APCC_DBOX_1
0.8634
p.R390W
SBC-1
lung
COSMIC
ARQLLRVLP
DEG_APCC_DBOX_1
0.8634
p.R394Q
TCGA-D1-A15X
UCEC
TCGA
ARQLLRVLP
DEG_APCC_DBOX_1
0.6218
p.R394Q
DO43274
UCEC
ICGC
ARQLLRVLP
DEG_APCC_DBOX_1
0.6218
p.V407F
TCGA-VQ-AA64
STAD
TCGA
ARQLLRVLP
DEG_APCC_DBOX_1
0.0556
p.V407F
DO222381
STAD
ICGC
ARQLLRVLP
DEG_APCC_DBOX_1
0.0556
p.A389T
DO50921
LICA
ICGC
ARQLLRVLP
DEG_APCC_DBOX_1
0.6028
p.L396P
DO229248
THCA
ICGC
ARQLLRVLP
DEG_APCC_DBOX_1
0.7582
p.S385G
SIDM00596
Endometrial Carcinoma
GDSC
ARQLLRVLP
DEG_APCC_DBOX_1
0.2222
p.S385G
ACH-001517
Endometrial/Uterine Cancer
CCLE
ARQLLRVLP
DEG_APCC_DBOX_1
0.2222
p.S385G
HEC-1
endometrium
COSMIC
ARQLLRVLP
DEG_APCC_DBOX_1
0.2222
Drug responses associated with RNF44 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of ARQLLRVLP
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q7L0R7
RING finger protein 44
DEG_APCC_DBOX_1
389:397
ARQLLRVLP
APC,CDC20,FZR1
0.5208
More...