DegronMD - Q9NV92(NDFIP2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S153R	TCGA-13-1501	OV	TCGA	VPTTS	DEG_SPOP_SBC_1	158:162	Mutation rewiring degron network	0.1944
p.S153R	TCGA-13-1501	OV	TCGA	PPPY	ITCH	148:151	Mutation rewiring degron network	0.2778
p.S153R	DO28168	OV	ICGC	VPTTS	DEG_SPOP_SBC_1	158:162	Mutation rewiring degron network	0.1944
p.S153R	DO28168	OV	ICGC	PPPY	ITCH	148:151	Mutation rewiring degron network	0.2778
p.L183V	TCGA-93-8067	LUAD	TCGA	PPPY	ITCH	174:177	Mutation rewiring degron network	0.1667
p.L183V	DO25113	LUAD	ICGC	PPPY	ITCH	174:177	Mutation rewiring degron network	0.1667
p.T68M	TCGA-AO-A0J9	BRCA	TCGA	AATTS	DEG_SPOP_SBC_1	65:69	Mutation altering degron motif	0.7423
p.T68M	DO3221	BRCA	ICGC	AATTS	DEG_SPOP_SBC_1	65:69	Mutation altering degron motif	0.7423
p.T181S	TCGA-BJ-A28S	THCA	TCGA	PPPY	ITCH	174:177	Mutation rewiring degron network	0.2222
p.T181S	DO48141	THCA	ICGC	PPPY	ITCH	174:177	Mutation rewiring degron network	0.2222
p.P149S	TCGA-D3-A5GU	SKCM	TCGA	PPPY	ITCH	148:151	Mutation altering degron motif	0.6752
p.P149S	DO47584	SKCM	ICGC	PPPY	ITCH	148:151	Mutation altering degron motif	0.6752
p.T181N	TCGA-DF-A2KN	UCEC	TCGA	PPPY	ITCH	174:177	Mutation rewiring degron network	0.2222
p.T181N	DO223282	UCEC	ICGC	PPPY	ITCH	174:177	Mutation rewiring degron network	0.2222
p.P159H	TCGA-EE-A181	SKCM	TCGA	VPTTS	DEG_SPOP_SBC_1	158:162	Mutation altering degron motif	0.6583
p.P159H	DO37444	SKCM	ICGC	VPTTS	DEG_SPOP_SBC_1	158:162	Mutation altering degron motif	0.6583
p.G168C	TCGA-EE-A2MM	SKCM	TCGA	VPTTS	DEG_SPOP_SBC_1	158:162	Mutation rewiring degron network	0.1667
p.G168C	TCGA-EE-A2MM	SKCM	TCGA	PPPY	ITCH	174:177	Mutation rewiring degron network	0.1667
p.G168C	DO37770	SKCM	ICGC	VPTTS	DEG_SPOP_SBC_1	158:162	Mutation rewiring degron network	0.1667
p.G168C	DO37770	SKCM	ICGC	PPPY	ITCH	174:177	Mutation rewiring degron network	0.1667
p.P184H	TCGA-EE-A3AC	SKCM	TCGA	PPPY	ITCH	174:177	Mutation rewiring degron network	0.1389
p.P184H	DO37631	SKCM	ICGC	PPPY	ITCH	174:177	Mutation rewiring degron network	0.1389
p.T68S	DO50090	COAD	ICGC	AATTS	DEG_SPOP_SBC_1	65:69	Mutation altering degron motif	0.6005
p.V173M	DO234187	ESAD	ICGC	PPPY	ITCH	174:177	Mutation rewiring degron network	0.3056
p.V173M	SIDM00160	Biliary Tract Carcinoma	GDSC	PPPY	ITCH	174:177	Mutation rewiring degron network	0.3056
p.V173M	ACH-000377	Bile Duct Cancer	CCLE	PPPY	ITCH	174:177	Mutation rewiring degron network	0.3056
p.V173M	ACH-000737	Lung Cancer	CCLE	PPPY	ITCH	174:177	Mutation rewiring degron network	0.3056
p.R57G	DO233096	GACA	ICGC	AATTS	DEG_SPOP_SBC_1	65:69	Mutation rewiring degron network	0.1111
p.A65S	DO16881	KIRC	ICGC	AATTS	DEG_SPOP_SBC_1	65:69	Mutation altering degron motif	0.7588
p.V179F	DO229041	LICA	ICGC	PPPY	ITCH	174:177	Mutation rewiring degron network	0.2778
p.D163Y	DO229052	LICA	ICGC	VPTTS	DEG_SPOP_SBC_1	158:162	Mutation rewiring degron network	0.3056
p.P172L	DO222595	MELA	ICGC	VPTTS	DEG_SPOP_SBC_1	158:162	Mutation rewiring degron network	0.0556
p.P172L	DO222595	MELA	ICGC	PPPY	ITCH	174:177	Mutation rewiring degron network	0.2778
p.P172L	DO222875	MELA	ICGC	VPTTS	DEG_SPOP_SBC_1	158:162	Mutation rewiring degron network	0.0556
p.P172L	DO222875	MELA	ICGC	PPPY	ITCH	174:177	Mutation rewiring degron network	0.2778
p.T160A	DO229213	THCA	ICGC	VPTTS	DEG_SPOP_SBC_1	158:162	Mutation altering degron motif	0.7139
p.D187N	SIDM02013	Colorectal Carcinoma	GDSC	PPPY	ITCH	174:177	Mutation rewiring degron network	0.0556
p.S152N	SIDM01175	Other Sarcomas	GDSC	VPTTS	DEG_SPOP_SBC_1	158:162	Mutation rewiring degron network	0.1667
p.S152N	SIDM01175	Other Sarcomas	GDSC	PPPY	ITCH	148:151	Mutation rewiring degron network	0.3056
p.S152N	SIDM00942	Oral Cavity Carcinoma	GDSC	VPTTS	DEG_SPOP_SBC_1	158:162	Mutation rewiring degron network	0.1667
p.S152N	SIDM00942	Oral Cavity Carcinoma	GDSC	PPPY	ITCH	148:151	Mutation rewiring degron network	0.3056
p.S152N	SIDM00102	Mesothelioma	GDSC	VPTTS	DEG_SPOP_SBC_1	158:162	Mutation rewiring degron network	0.1667
p.S152N	SIDM00102	Mesothelioma	GDSC	PPPY	ITCH	148:151	Mutation rewiring degron network	0.3056
p.S152N	SIDM01693	B-Lymphoblastic Leukemia	GDSC	VPTTS	DEG_SPOP_SBC_1	158:162	Mutation rewiring degron network	0.1667
p.S152N	SIDM01693	B-Lymphoblastic Leukemia	GDSC	PPPY	ITCH	148:151	Mutation rewiring degron network	0.3056
p.G63V	ACH-000253	Colon/Colorectal Cancer	CCLE	AATTS	DEG_SPOP_SBC_1	65:69	Mutation rewiring degron network	0.2778
p.C155Y	NCI-H1155	lung	COSMIC	VPTTS	DEG_SPOP_SBC_1	158:162	Mutation rewiring degron network	0.25
p.C155Y	NCI-H1155	lung	COSMIC	PPPY	ITCH	148:151	Mutation rewiring degron network	0.2222

Kaplan plot for NDFIP2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NDFIP2

UniProt ID: Q9NV92

Entrez ID: 54602

Protein name: NEDD4 family-interacting protein 2 (NEDD4 WW domain-binding protein 5A) (Putative MAPK-activating protein PM04/PM05/PM06/PM07) (Putative NF-kappa-B-activating protein 413)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for NDFIP2 in