DegronMD - Q9NRM7(LATS2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P516L	TCGA-18-3409	LUSC	TCGA	PPPY	ITCH	515:518	Mutation altering degron motif	0.7582
p.P516L	DO26444	LUSC	ICGC	PPPY	ITCH	515:518	Mutation altering degron motif	0.7582
p.P516L	ACH-000950	Colon/Colorectal Cancer	CCLE	PPPY	ITCH	515:518	Mutation altering degron motif	0.7582
p.S528L	TCGA-2W-A8YY	CESC	TCGA	PPPY	ITCH	515:518	Mutation blocking phosphorylation signal	0.5
p.S528L	TCGA-46-3769	LUSC	TCGA	PPPY	ITCH	515:518	Mutation blocking phosphorylation signal	0.5
p.S528L	DO223732	CESC	ICGC	PPPY	ITCH	515:518	Mutation blocking phosphorylation signal	0.5
p.S528L	DO26590	LUSC	ICGC	PPPY	ITCH	515:518	Mutation blocking phosphorylation signal	0.5
p.R16L	TCGA-73-4666	LUAD	TCGA	SRQRLQEIR	DEG_APCC_DBOX_1	15:23	Mutation altering degron motif	0.8428
p.R16L	DO26230	LUAD	ICGC	SRQRLQEIR	DEG_APCC_DBOX_1	15:23	Mutation altering degron motif	0.8428
p.R23C	TCGA-90-A4ED	LUSC	TCGA	SRQRLQEIR	DEG_APCC_DBOX_1	15:23	Mutation altering degron motif	0.719
p.R23C	DO45482	LUSC	ICGC	SRQRLQEIR	DEG_APCC_DBOX_1	15:23	Mutation altering degron motif	0.719
p.S33L	TCGA-AG-A002	READ	TCGA	SRQRLQEIR	DEG_APCC_DBOX_1	15:23	Mutation rewiring degron network	0.0556
p.P509S	TCGA-B0-4810	KIRC	TCGA	PPPY	ITCH	515:518	Mutation rewiring degron network	0.1667
p.P509S	DO17643	KIRC	ICGC	PPPY	ITCH	515:518	Mutation rewiring degron network	0.1667
p.R525C	TCGA-BT-A20J	BLCA	TCGA	PPPY	ITCH	515:518	Mutation rewiring degron network	0.1389
p.R525C	DO457	BLCA	ICGC	PPPY	ITCH	515:518	Mutation rewiring degron network	0.1389
p.R525C	SIDM00216	Colorectal Carcinoma	GDSC	PPPY	ITCH	515:518	Mutation rewiring degron network	0.1389
p.R525C	SIDM01146	Gastric Carcinoma	GDSC	PPPY	ITCH	515:518	Mutation rewiring degron network	0.1389
p.R525C	SIDM01618	B-Lymphoblastic Leukemia	GDSC	PPPY	ITCH	515:518	Mutation rewiring degron network	0.1389
p.R525C	ACH-000932	Gastric Cancer	CCLE	PPPY	ITCH	515:518	Mutation rewiring degron network	0.1389
p.R525C	ACH-000942	Leukemia	CCLE	PPPY	ITCH	515:518	Mutation rewiring degron network	0.1389
p.R525C	ACH-000989	Colon/Colorectal Cancer	CCLE	PPPY	ITCH	515:518	Mutation rewiring degron network	0.1389
p.R525C	SNU-175	large intestine	COSMIC	PPPY	ITCH	515:518	Mutation rewiring degron network	0.1389
p.R525C	NCI-SNU-1	stomach	COSMIC	PPPY	ITCH	515:518	Mutation rewiring degron network	0.1389
p.R16Q	TCGA-F4-6570	COAD	TCGA	SRQRLQEIR	DEG_APCC_DBOX_1	15:23	Mutation altering degron motif	0.7329
p.R16Q	DO10443	COAD	ICGC	SRQRLQEIR	DEG_APCC_DBOX_1	15:23	Mutation altering degron motif	0.7329
p.I22S	TCGA-F5-6814	READ	TCGA	SRQRLQEIR	DEG_APCC_DBOX_1	15:23	Mutation altering degron motif	0.7341
p.I22S	DO36556	READ	ICGC	SRQRLQEIR	DEG_APCC_DBOX_1	15:23	Mutation altering degron motif	0.7341
p.P516S	DO228260	BRCA	ICGC	PPPY	ITCH	515:518	Mutation altering degron motif	0.6752
p.R511W	DO44086	COAD	ICGC	PPPY	ITCH	515:518	Mutation rewiring degron network	0.2222
p.A8D	DO229028	LICA	ICGC	SRQRLQEIR	DEG_APCC_DBOX_1	15:23	Mutation rewiring degron network	0.1389
p.Q28K	DO229035	LICA	ICGC	SRQRLQEIR	DEG_APCC_DBOX_1	15:23	Mutation rewiring degron network	0.1944
p.T9K	DO229035	LICA	ICGC	SRQRLQEIR	DEG_APCC_DBOX_1	15:23	Mutation blocking phosphorylation signal	0.6111
p.R512S	DO44666	LICA	ICGC	PPPY	ITCH	515:518	Mutation rewiring degron network	0.25
p.I22V	DO23236	LINC	ICGC	SRQRLQEIR	DEG_APCC_DBOX_1	15:23	Mutation altering degron motif	0.5965
p.G507R	SIDM00762	Non-Small Cell Lung Carcinoma	GDSC	PPPY	ITCH	515:518	Mutation rewiring degron network	0.1111
p.G507R	ACH-000414	Lung Cancer	CCLE	PPPY	ITCH	515:518	Mutation rewiring degron network	0.1111
p.G507R	NCI-H1944	lung	COSMIC	PPPY	ITCH	515:518	Mutation rewiring degron network	0.1111
p.P514T	SIDM01007	T-Lymphoblastic Leukemia	GDSC	PPPY	ITCH	515:518	Mutation rewiring degron network	0.3056
p.P514T	ACH-002256	Leukemia	CCLE	PPPY	ITCH	515:518	Mutation rewiring degron network	0.3056
p.P514T	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	PPPY	ITCH	515:518	Mutation rewiring degron network	0.3056
p.Y506F	SIDM01078	Small Cell Lung Carcinoma	GDSC	PPPY	ITCH	515:518	Mutation rewiring degron network	0.0833
p.Y506F	ACH-000790	Lung Cancer	CCLE	PPPY	ITCH	515:518	Mutation rewiring degron network	0.0833
p.Y506F	SHP-77	lung	COSMIC	PPPY	ITCH	515:518	Mutation rewiring degron network	0.0833
p.R525H	SIDM01051	Ovarian Carcinoma	GDSC	PPPY	ITCH	515:518	Mutation rewiring degron network	0.1389
p.R525H	ACH-000936	Ovarian Cancer	CCLE	PPPY	ITCH	515:518	Mutation rewiring degron network	0.1389
p.R525H	EFO-27	ovary	COSMIC	PPPY	ITCH	515:518	Mutation rewiring degron network	0.1389
p.E505G	SIDM01608	Endometrial Carcinoma	GDSC	PPPY	ITCH	515:518	Mutation rewiring degron network	0.0556
p.E505G	ACH-000990	Endometrial/Uterine Cancer	CCLE	PPPY	ITCH	515:518	Mutation rewiring degron network	0.0556

Kaplan plot for LATS2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

LATS2

UniProt ID: Q9NRM7

Entrez ID: 26524

Protein name: Serine/threonine-protein kinase LATS2 (EC 2.7.11.1) (Kinase phosphorylated during mitosis protein) (Large tumor suppressor homolog 2) (Serine/threonine-protein kinase kpm) (Warts-like kinase)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for LATS2 in