DegronMD

Uniprot ID: Q9NRM7

Source protein: Serine/threonine-protein kinase LATS2

Source gene: LATS2

Class: DEG_APCC_DBOX_1

Location: 15:23

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9203

ASA_SCORE: 72.9

COIL: 0.0722

CONS_SCORE: 0.3748

DSS_SCORE: 0.6908

HELIX: 0.9237

FCONS_SCORE: 1.11

RIG_SCORE: 0.7348

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R16L	TCGA-73-4666	LUAD	TCGA	SRQRLQEIR	DEG_APCC_DBOX_1	0.8428
p.R16L	DO26230	LUAD	ICGC	SRQRLQEIR	DEG_APCC_DBOX_1	0.8428
p.R23C	TCGA-90-A4ED	LUSC	TCGA	SRQRLQEIR	DEG_APCC_DBOX_1	0.719
p.R23C	DO45482	LUSC	ICGC	SRQRLQEIR	DEG_APCC_DBOX_1	0.719
p.S33L	TCGA-AG-A002	READ	TCGA	SRQRLQEIR	DEG_APCC_DBOX_1	0.0556
p.R16Q	TCGA-F4-6570	COAD	TCGA	SRQRLQEIR	DEG_APCC_DBOX_1	0.7329
p.R16Q	DO10443	COAD	ICGC	SRQRLQEIR	DEG_APCC_DBOX_1	0.7329
p.I22S	TCGA-F5-6814	READ	TCGA	SRQRLQEIR	DEG_APCC_DBOX_1	0.7341
p.I22S	DO36556	READ	ICGC	SRQRLQEIR	DEG_APCC_DBOX_1	0.7341
p.A8D	DO229028	LICA	ICGC	SRQRLQEIR	DEG_APCC_DBOX_1	0.1389
p.Q28K	DO229035	LICA	ICGC	SRQRLQEIR	DEG_APCC_DBOX_1	0.1944
p.T9K	DO229035	LICA	ICGC	SRQRLQEIR	DEG_APCC_DBOX_1	0.6111
p.I22V	DO23236	LINC	ICGC	SRQRLQEIR	DEG_APCC_DBOX_1	0.5965

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NRM7	Serine/threonine-protein kinase LATS2	DEG_APCC_DBOX_1	15:23	SRQRLQEIR	APC,CDC20,FZR1	0.9203	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons