DegronMD - Q13480(GAB1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Y317C	TCGA-05-4390	LUAD	TCGA	IPPTPGNT	DEG_SCF_FBW7_1	309:316	Mutation blocking phosphorylation signal	0.75
p.Y317C	DO23562	LUAD	ICGC	IPPTPGNT	DEG_SCF_FBW7_1	309:316	Mutation blocking phosphorylation signal	0.75
p.D630V	TCGA-34-5234	LUSC	TCGA	DSGKST	DEG_SCF_TRCP1_1	633:638	Mutation rewiring degron network	0.25
p.D630V	DO26810	LUSC	ICGC	DSGKST	DEG_SCF_TRCP1_1	633:638	Mutation rewiring degron network	0.25
p.D152V	TCGA-55-A48Y	LUAD	TCGA	ADSSS	DEG_SPOP_SBC_1	151:155	Mutation altering degron motif	0.6674
p.D152V	DO26160	LUAD	ICGC	ADSSS	DEG_SPOP_SBC_1	151:155	Mutation altering degron motif	0.6674
p.P645H	TCGA-A5-A0G1	UCEC	TCGA	DSGKST	DEG_SCF_TRCP1_1	633:638	Mutation blocking phosphorylation signal	0.5833
p.P645H	DO42472	UCEC	ICGC	DSGKST	DEG_SCF_TRCP1_1	633:638	Mutation blocking phosphorylation signal	0.5833
p.T199M	TCGA-A5-A2K7	UCEC	TCGA	AKSTS	DEG_SPOP_SBC_1	204:208	Mutation rewiring degron network	0.1944
p.T199M	TCGA-AP-A1E0	UCEC	TCGA	AKSTS	DEG_SPOP_SBC_1	204:208	Mutation rewiring degron network	0.1944
p.T199M	DO43154	UCEC	ICGC	AKSTS	DEG_SPOP_SBC_1	204:208	Mutation rewiring degron network	0.1944
p.T199M	DO41271	UCEC	ICGC	AKSTS	DEG_SPOP_SBC_1	204:208	Mutation rewiring degron network	0.1944
p.I176M	TCGA-AP-A1E0	UCEC	TCGA	VPPHLE	LIG_APCC_ABBA_1	167:172	Mutation rewiring degron network	0.2222
p.I176M	DO43154	UCEC	ICGC	VPPHLE	LIG_APCC_ABBA_1	167:172	Mutation rewiring degron network	0.2222
p.E195K	TCGA-AZ-4315	COAD	TCGA	AKSTS	DEG_SPOP_SBC_1	204:208	Mutation rewiring degron network	0.0833
p.E195K	DO8842	COAD	ICGC	AKSTS	DEG_SPOP_SBC_1	204:208	Mutation rewiring degron network	0.0833
p.E195K	DO231956	LICA	ICGC	AKSTS	DEG_SPOP_SBC_1	204:208	Mutation rewiring degron network	0.0833
p.A204T	TCGA-BR-4184	STAD	TCGA	AKSTS	DEG_SPOP_SBC_1	204:208	Mutation altering degron motif	0.7139
p.A204T	DO38328	STAD	ICGC	AKSTS	DEG_SPOP_SBC_1	204:208	Mutation altering degron motif	0.7139
p.A204T	ACH-001134	Lymphoma	CCLE	AKSTS	DEG_SPOP_SBC_1	204:208	Mutation altering degron motif	0.7139
p.R321Q	TCGA-BR-7703	STAD	TCGA	IPPTPGNT	DEG_SCF_FBW7_1	309:316	Mutation rewiring degron network	0.1944
p.R321Q	DO218506	BRCA	ICGC	IPPTPGNT	DEG_SCF_FBW7_1	309:316	Mutation rewiring degron network	0.1944
p.R321Q	DO38232	STAD	ICGC	IPPTPGNT	DEG_SCF_FBW7_1	309:316	Mutation rewiring degron network	0.1944
p.S155F	TCGA-CR-6472	HNSC	TCGA	ADSSS	DEG_SPOP_SBC_1	151:155	Mutation altering degron motif	0.7982
p.S155F	TCGA-EE-A3J5	SKCM	TCGA	ADSSS	DEG_SPOP_SBC_1	151:155	Mutation altering degron motif	0.7982
p.S155F	DO15870	HNSC	ICGC	ADSSS	DEG_SPOP_SBC_1	151:155	Mutation altering degron motif	0.7982
p.S155F	DO47331	SKCM	ICGC	ADSSS	DEG_SPOP_SBC_1	151:155	Mutation altering degron motif	0.7982
p.S155F	SIDM00749	Non-Small Cell Lung Carcinoma	GDSC	ADSSS	DEG_SPOP_SBC_1	151:155	Mutation altering degron motif	0.7982
p.S155F	ACH-000916	Lung Cancer	CCLE	ADSSS	DEG_SPOP_SBC_1	151:155	Mutation altering degron motif	0.7982
p.S155F	NCI-H1573	lung	COSMIC	ADSSS	DEG_SPOP_SBC_1	151:155	Mutation altering degron motif	0.7982
p.Q318E	TCGA-CV-A6JM	HNSC	TCGA	IPPTPGNT	DEG_SCF_FBW7_1	309:316	Mutation rewiring degron network	0.2778
p.Q318E	DO49991	HNSC	ICGC	IPPTPGNT	DEG_SCF_FBW7_1	309:316	Mutation rewiring degron network	0.2778
p.P324A	TCGA-CV-A6JM	HNSC	TCGA	IPPTPGNT	DEG_SCF_FBW7_1	309:316	Mutation rewiring degron network	0.1111
p.P324A	DO49991	HNSC	ICGC	IPPTPGNT	DEG_SCF_FBW7_1	309:316	Mutation rewiring degron network	0.1111
p.G292W	TCGA-EE-A184	SKCM	TCGA	VFNTPSGT	DEG_SCF_FBW7_1	286:293	Mutation altering degron motif	0.6714
p.G292W	DO47442	SKCM	ICGC	VFNTPSGT	DEG_SCF_FBW7_1	286:293	Mutation altering degron motif	0.6714
p.P169L	TCGA-EE-A2MR	SKCM	TCGA	VPPHLE	LIG_APCC_ABBA_1	167:172	Mutation altering degron motif	0.6471
p.P169L	DO37819	SKCM	ICGC	VPPHLE	LIG_APCC_ABBA_1	167:172	Mutation altering degron motif	0.6471
p.N625T	TCGA-FI-A2D5	UCEC	TCGA	DSGKST	DEG_SCF_TRCP1_1	633:638	Mutation rewiring degron network	0.1111
p.N625T	DO41331	UCEC	ICGC	DSGKST	DEG_SCF_TRCP1_1	633:638	Mutation rewiring degron network	0.1111
p.P310S	TCGA-FW-A3R5	SKCM	TCGA	IPPTPGNT	DEG_SCF_FBW7_1	309:316	Mutation altering degron motif	0.5641
p.P310S	DO37406	SKCM	ICGC	IPPTPGNT	DEG_SCF_FBW7_1	309:316	Mutation altering degron motif	0.5641
p.A141T	TCGA-L5-A8NU	ESCA	TCGA	ADSSS	DEG_SPOP_SBC_1	151:155	Mutation rewiring degron network	0.0556
p.P159T	TCGA-XF-A8HG	BLCA	TCGA	PPPY	ITCH	159:162	Mutation altering degron motif	0.7031
p.P159T	DO49802	BLCA	ICGC	PPPY	ITCH	159:162	Mutation altering degron motif	0.7031
p.T289N	TCGA-XK-AAIW	PRAD	TCGA	VFNTPSGT	DEG_SCF_FBW7_1	286:293	Mutation altering degron motif	0.7055
p.T289N	DO51407	PRAD	ICGC	VFNTPSGT	DEG_SCF_FBW7_1	286:293	Mutation altering degron motif	0.7055
p.P311L	DO234204	ESAD	ICGC	IPPTPGNT	DEG_SCF_FBW7_1	309:316	Mutation altering degron motif	0.6471
p.M300L	DO233686	GACA	ICGC	VFNTPSGT	DEG_SCF_FBW7_1	286:293	Mutation rewiring degron network	0.1389
p.M300L	DO233686	GACA	ICGC	IPPTPGNT	DEG_SCF_FBW7_1	309:316	Mutation rewiring degron network	0.0833
p.V217F	DO233882	GACA	ICGC	AKSTS	DEG_SPOP_SBC_1	204:208	Mutation rewiring degron network	0.0833
p.V217F	DO229015	LICA	ICGC	AKSTS	DEG_SPOP_SBC_1	204:208	Mutation rewiring degron network	0.0833
p.V217F	DO229045	LICA	ICGC	AKSTS	DEG_SPOP_SBC_1	204:208	Mutation rewiring degron network	0.0833
p.G635C	DO228948	LICA	ICGC	DSGKST	DEG_SCF_TRCP1_1	633:638	Mutation altering degron motif	0.76
p.S295I	DO228976	LICA	ICGC	VFNTPSGT	DEG_SCF_FBW7_1	286:293	Mutation rewiring degron network	0.2778
p.G175C	DO229019	LICA	ICGC	VPPHLE	LIG_APCC_ABBA_1	167:172	Mutation rewiring degron network	0.25
p.S277I	DO229034	LICA	ICGC	VFNTPSGT	DEG_SCF_FBW7_1	286:293	Mutation rewiring degron network	0.0833
p.A141S	DO229038	LICA	ICGC	ADSSS	DEG_SPOP_SBC_1	151:155	Mutation rewiring degron network	0.0556
p.D630G	DO45299	LIRI	ICGC	DSGKST	DEG_SCF_TRCP1_1	633:638	Mutation rewiring degron network	0.25
p.S153L	DO220901	MELA	ICGC	ADSSS	DEG_SPOP_SBC_1	151:155	Mutation altering degron motif	0.7667
p.P194S	SIDM00388	B-Cell Non-Hodgkin's Lymphoma	GDSC	AKSTS	DEG_SPOP_SBC_1	204:208	Mutation rewiring degron network	0.0556
p.P194S	ACH-002272	Lymphoma	CCLE	AKSTS	DEG_SPOP_SBC_1	204:208	Mutation rewiring degron network	0.0556
p.P194S	MHH-PREB-1	haematopoietic and lymphoid tissue	COSMIC	AKSTS	DEG_SPOP_SBC_1	204:208	Mutation rewiring degron network	0.0556
p.T293A	SIDM00388	B-Cell Non-Hodgkin's Lymphoma	GDSC	VFNTPSGT	DEG_SCF_FBW7_1	286:293	Mutation altering degron motif	0.7139
p.T293A	ACH-002272	Lymphoma	CCLE	VFNTPSGT	DEG_SCF_FBW7_1	286:293	Mutation altering degron motif	0.7139
p.T293A	MHH-PREB-1	haematopoietic and lymphoid tissue	COSMIC	VFNTPSGT	DEG_SCF_FBW7_1	286:293	Mutation altering degron motif	0.7139
p.T157A	SIDM01112	Osteosarcoma	GDSC	ADSSS	DEG_SPOP_SBC_1	151:155	Mutation rewiring degron network	0.2778
p.T157A	SIDM01112	Osteosarcoma	GDSC	VPPHLE	LIG_APCC_ABBA_1	167:172	Mutation rewiring degron network	0.0556
p.T157A	SIDM01112	Osteosarcoma	GDSC	PPPY	ITCH	159:162	Mutation rewiring degron network	0.2778
p.P624S	ACH-001566	Skin Cancer	CCLE	DSGKST	DEG_SCF_TRCP1_1	633:638	Mutation rewiring degron network	0.0833
p.S294L	ACH-001664	Gastric Cancer	CCLE	VFNTPSGT	DEG_SCF_FBW7_1	286:293	Mutation rewiring degron network	0.3056
p.M646V	ACH-002019	Cervical Cancer	CCLE	DSGKST	DEG_SCF_TRCP1_1	633:638	Mutation rewiring degron network	0.1111
p.D165N	MFE-319	endometrium	COSMIC	ADSSS	DEG_SPOP_SBC_1	151:155	Mutation rewiring degron network	0.0556
p.D165N	MFE-319	endometrium	COSMIC	VPPHLE	LIG_APCC_ABBA_1	167:172	Mutation rewiring degron network	0.2778
p.D165N	MFE-319	endometrium	COSMIC	PPPY	ITCH	159:162	Mutation rewiring degron network	0.25
p.R145H	NCI-H650	lung	COSMIC	ADSSS	DEG_SPOP_SBC_1	151:155	Mutation rewiring degron network	0.1667
p.L167S	NB1	autonomic ganglia	COSMIC	VPPHLE	LIG_APCC_ABBA_1	167:172	Mutation altering degron motif	0.7667
p.L167S	KYSE-180	oesophagus	COSMIC	VPPHLE	LIG_APCC_ABBA_1	167:172	Mutation altering degron motif	0.7667
p.L167S	IA-LM	lung	COSMIC	VPPHLE	LIG_APCC_ABBA_1	167:172	Mutation altering degron motif	0.7667
p.A308E	CML-T1	haematopoietic and lymphoid tissue	COSMIC	IPPTPGNT	DEG_SCF_FBW7_1	309:316	Mutation rewiring degron network	0.3056
p.P639S	HCT-15	large intestine	COSMIC	DSGKST	DEG_SCF_TRCP1_1	633:638	Mutation rewiring degron network	0.3056
p.T284N	HCC1954	breast	COSMIC	VFNTPSGT	DEG_SCF_FBW7_1	286:293	Mutation rewiring degron network	0.2778
p.D629E	CW-2	large intestine	COSMIC	DSGKST	DEG_SCF_TRCP1_1	633:638	Mutation rewiring degron network	0.2222
p.Y156H	Mewo	skin	COSMIC	ADSSS	DEG_SPOP_SBC_1	151:155	Mutation rewiring degron network	0.3056
p.Y156H	Mewo	skin	COSMIC	PPPY	ITCH	159:162	Mutation rewiring degron network	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

GAB1

UniProt ID: Q13480

Entrez ID: 2549

Protein name: GRB2-associated-binding protein 1 (GRB2-associated binder 1) (Growth factor receptor bound protein 2-associated protein 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for GAB1 in