DegronMD

Uniprot ID: Q13480

Source protein: GRB2-associated-binding protein 1

Source gene: GAB1

Class: DEG_SCF_FBW7_1

Location: 309:316

E3 ligase: FBXW7

DEGRON score: 0.9997

ASA_SCORE: 72.7375

COIL: 0.9704

CONS_SCORE: 0.3549

DSS_SCORE: 0.5252

HELIX: 0.0141

FCONS_SCORE: 0.9967

RIG_SCORE: 0.6653

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Y317C	TCGA-05-4390	LUAD	TCGA	IPPTPGNT	DEG_SCF_FBW7_1	0.75
p.Y317C	DO23562	LUAD	ICGC	IPPTPGNT	DEG_SCF_FBW7_1	0.75
p.R321Q	TCGA-BR-7703	STAD	TCGA	IPPTPGNT	DEG_SCF_FBW7_1	0.1944
p.R321Q	DO218506	BRCA	ICGC	IPPTPGNT	DEG_SCF_FBW7_1	0.1944
p.R321Q	DO38232	STAD	ICGC	IPPTPGNT	DEG_SCF_FBW7_1	0.1944
p.Q318E	TCGA-CV-A6JM	HNSC	TCGA	IPPTPGNT	DEG_SCF_FBW7_1	0.2778
p.Q318E	DO49991	HNSC	ICGC	IPPTPGNT	DEG_SCF_FBW7_1	0.2778
p.P324A	TCGA-CV-A6JM	HNSC	TCGA	IPPTPGNT	DEG_SCF_FBW7_1	0.1111
p.P324A	DO49991	HNSC	ICGC	IPPTPGNT	DEG_SCF_FBW7_1	0.1111
p.P310S	TCGA-FW-A3R5	SKCM	TCGA	IPPTPGNT	DEG_SCF_FBW7_1	0.5641
p.P310S	DO37406	SKCM	ICGC	IPPTPGNT	DEG_SCF_FBW7_1	0.5641
p.P311L	DO234204	ESAD	ICGC	IPPTPGNT	DEG_SCF_FBW7_1	0.6471
p.M300L	DO233686	GACA	ICGC	IPPTPGNT	DEG_SCF_FBW7_1	0.0833
p.A308E	CML-T1	haematopoietic_and_lymphoid_tissue	COSMIC	IPPTPGNT	DEG_SCF_FBW7_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13480	GRB2-associated-binding protein 1	DEG_SCF_FBW7_1	309:316	IPPTPGNT	FBXW7	0.9997	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons