DegronMD

Uniprot ID: Q13480

Source protein: GRB2-associated-binding protein 1

Source gene: GAB1

Class: DEG_SCF_FBW7_1

Location: 286:293

E3 ligase: FBXW7

DEGRON score: 0.9935

ASA_SCORE: 63.85

COIL: 0.7436

CONS_SCORE: 0.4264

DSS_SCORE: 0.4699

HELIX: 0.0261

FCONS_SCORE: 1.1943

RIG_SCORE: 0.7052

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G292W	TCGA-EE-A184	SKCM	TCGA	VFNTPSGT	DEG_SCF_FBW7_1	0.6714
p.G292W	DO47442	SKCM	ICGC	VFNTPSGT	DEG_SCF_FBW7_1	0.6714
p.T289N	TCGA-XK-AAIW	PRAD	TCGA	VFNTPSGT	DEG_SCF_FBW7_1	0.7055
p.T289N	DO51407	PRAD	ICGC	VFNTPSGT	DEG_SCF_FBW7_1	0.7055
p.M300L	DO233686	GACA	ICGC	VFNTPSGT	DEG_SCF_FBW7_1	0.1389
p.S295I	DO228976	LICA	ICGC	VFNTPSGT	DEG_SCF_FBW7_1	0.2778
p.S277I	DO229034	LICA	ICGC	VFNTPSGT	DEG_SCF_FBW7_1	0.0833
p.T293A	SIDM00388	B-Cell Non-Hodgkin's Lymphoma	GDSC	VFNTPSGT	DEG_SCF_FBW7_1	0.7139
p.T293A	ACH-002272	Lymphoma	CCLE	VFNTPSGT	DEG_SCF_FBW7_1	0.7139
p.T293A	MHH-PREB-1	haematopoietic_and_lymphoid_tissue	COSMIC	VFNTPSGT	DEG_SCF_FBW7_1	0.7139
p.S294L	ACH-001664	Gastric Cancer	CCLE	VFNTPSGT	DEG_SCF_FBW7_1	0.3056
p.T284N	HCC1954	breast	COSMIC	VFNTPSGT	DEG_SCF_FBW7_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13480	GRB2-associated-binding protein 1	DEG_SCF_FBW7_1	286:293	VFNTPSGT	FBXW7	0.9935	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons