DegronMD

Uniprot ID: Q13480

Source protein: GRB2-associated-binding protein 1

Source gene: GAB1

Class: LIG_APCC_ABBA_1

Location: 167:172

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9855

ASA_SCORE: 98.9667

COIL: 0.9392

CONS_SCORE: 0.3565

DSS_SCORE: 0.4856

HELIX: 0.0305

FCONS_SCORE: 0.8894

RIG_SCORE: 0.743

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I176M	TCGA-AP-A1E0	UCEC	TCGA	VPPHLE	LIG_APCC_ABBA_1	0.2222
p.I176M	DO43154	UCEC	ICGC	VPPHLE	LIG_APCC_ABBA_1	0.2222
p.P169L	TCGA-EE-A2MR	SKCM	TCGA	VPPHLE	LIG_APCC_ABBA_1	0.6471
p.P169L	DO37819	SKCM	ICGC	VPPHLE	LIG_APCC_ABBA_1	0.6471
p.G175C	DO229019	LICA	ICGC	VPPHLE	LIG_APCC_ABBA_1	0.25
p.T157A	SIDM01112	Osteosarcoma	GDSC	VPPHLE	LIG_APCC_ABBA_1	0.0556
p.D165N	MFE-319	endometrium	COSMIC	VPPHLE	LIG_APCC_ABBA_1	0.2778
p.L167S	NB1	autonomic_ganglia	COSMIC	VPPHLE	LIG_APCC_ABBA_1	0.7667
p.L167S	KYSE-180	oesophagus	COSMIC	VPPHLE	LIG_APCC_ABBA_1	0.7667
p.L167S	IA-LM	lung	COSMIC	VPPHLE	LIG_APCC_ABBA_1	0.7667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13480	GRB2-associated-binding protein 1	LIG_APCC_ABBA_1	167:172	VPPHLE	APC,CDC20,FZR1	0.9855	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons