DegronMD

Uniprot ID: Q13480

Source protein: GRB2-associated-binding protein 1

Source gene: GAB1

Class: DEG_SPOP_SBC_1

Location: 204:208

E3 ligase: SPOP

DEGRON score: 0.7361

ASA_SCORE: 89.7

COIL: 0.8988

CONS_SCORE: 0.3688

DSS_SCORE: 0.6318

HELIX: 0.0796

FCONS_SCORE: 1.0523

RIG_SCORE: 0.5717

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T199M	TCGA-A5-A2K7	UCEC	TCGA	AKSTS	DEG_SPOP_SBC_1	0.1944
p.T199M	TCGA-AP-A1E0	UCEC	TCGA	AKSTS	DEG_SPOP_SBC_1	0.1944
p.T199M	DO43154	UCEC	ICGC	AKSTS	DEG_SPOP_SBC_1	0.1944
p.T199M	DO41271	UCEC	ICGC	AKSTS	DEG_SPOP_SBC_1	0.1944
p.E195K	TCGA-AZ-4315	COAD	TCGA	AKSTS	DEG_SPOP_SBC_1	0.0833
p.E195K	DO8842	COAD	ICGC	AKSTS	DEG_SPOP_SBC_1	0.0833
p.E195K	DO231956	LICA	ICGC	AKSTS	DEG_SPOP_SBC_1	0.0833
p.A204T	TCGA-BR-4184	STAD	TCGA	AKSTS	DEG_SPOP_SBC_1	0.7139
p.A204T	DO38328	STAD	ICGC	AKSTS	DEG_SPOP_SBC_1	0.7139
p.A204T	ACH-001134	Lymphoma	CCLE	AKSTS	DEG_SPOP_SBC_1	0.7139
p.V217F	DO233882	GACA	ICGC	AKSTS	DEG_SPOP_SBC_1	0.0833
p.V217F	DO229015	LICA	ICGC	AKSTS	DEG_SPOP_SBC_1	0.0833
p.V217F	DO229045	LICA	ICGC	AKSTS	DEG_SPOP_SBC_1	0.0833
p.P194S	SIDM00388	B-Cell Non-Hodgkin's Lymphoma	GDSC	AKSTS	DEG_SPOP_SBC_1	0.0556
p.P194S	ACH-002272	Lymphoma	CCLE	AKSTS	DEG_SPOP_SBC_1	0.0556
p.P194S	MHH-PREB-1	haematopoietic_and_lymphoid_tissue	COSMIC	AKSTS	DEG_SPOP_SBC_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P49792	E3 SUMO-protein ligase RanBP2	DEG_SPOP_SBC_1	1951:1955	AKSTS	SPOP	0.8024	More...
P58304	Visual system homeobox 2	DEG_SPOP_SBC_1	18:22	AKSTS	SPOP	0.9689	More...
Q13480	GRB2-associated-binding protein 1	DEG_SPOP_SBC_1	204:208	AKSTS	SPOP	0.7361	More...
Q8WWL2	Protein spire homolog 2	DEG_SPOP_SBC_1	383:387	AKSTS	SPOP	0.6134	More...
Q9NSC2	Sal-like protein 1	DEG_SPOP_SBC_1	438:442	AKSTS	SPOP	0.9731	More...
A6NKT7	RanBP2-like and GRIP domain-containing protein 3	DEG_SPOP_SBC_1	976:980	AKSTS	SPOP	0.8902	More...
P0DJD0	RANBP2-like and GRIP domain-containing protein 1	DEG_SPOP_SBC_1	960:964	AKSTS	SPOP	0.9976	More...
P0DJD1	RANBP2-like and GRIP domain-containing protein 2	DEG_SPOP_SBC_1	968:972	AKSTS	SPOP	0.9478	More...
Q569K6	Coiled-coil domain-containing protein 157	DEG_SPOP_SBC_1	643:647	AKSTS	SPOP	0.7532	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons