DegronMD

Uniprot ID: Q8WWL2

Source protein: Protein spire homolog 2

Source gene: SPIRE2

Class: DEG_SPOP_SBC_1

Location: 383:387

E3 ligase: SPOP

DEGRON score: 0.6134

ASA_SCORE: 70.7

COIL: 0.6492

CONS_SCORE: 0.3861

DSS_SCORE: 0.1348

HELIX: 0.1796

FCONS_SCORE: 1.1567

RIG_SCORE: 0.7479

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.C374F	TCGA-DD-A11A	LIHC	TCGA	AKSTS	DEG_SPOP_SBC_1	0.0833
p.C374F	DO22835	LIHC	ICGC	AKSTS	DEG_SPOP_SBC_1	0.0833
p.S392L	TCGA-EE-A29S	SKCM	TCGA	AKSTS	DEG_SPOP_SBC_1	0.6389
p.S392L	DO37936	SKCM	ICGC	AKSTS	DEG_SPOP_SBC_1	0.6389
p.D395G	TCGA-L5-A88S	ESCA	TCGA	AKSTS	DEG_SPOP_SBC_1	0.1111
p.P373T	DO229242	THCA	ICGC	AKSTS	DEG_SPOP_SBC_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P49792	E3 SUMO-protein ligase RanBP2	DEG_SPOP_SBC_1	1951:1955	AKSTS	SPOP	0.8024	More...
P58304	Visual system homeobox 2	DEG_SPOP_SBC_1	18:22	AKSTS	SPOP	0.9689	More...
Q13480	GRB2-associated-binding protein 1	DEG_SPOP_SBC_1	204:208	AKSTS	SPOP	0.7361	More...
Q8WWL2	Protein spire homolog 2	DEG_SPOP_SBC_1	383:387	AKSTS	SPOP	0.6134	More...
Q9NSC2	Sal-like protein 1	DEG_SPOP_SBC_1	438:442	AKSTS	SPOP	0.9731	More...
A6NKT7	RanBP2-like and GRIP domain-containing protein 3	DEG_SPOP_SBC_1	976:980	AKSTS	SPOP	0.8902	More...
P0DJD0	RANBP2-like and GRIP domain-containing protein 1	DEG_SPOP_SBC_1	960:964	AKSTS	SPOP	0.9976	More...
P0DJD1	RANBP2-like and GRIP domain-containing protein 2	DEG_SPOP_SBC_1	968:972	AKSTS	SPOP	0.9478	More...
Q569K6	Coiled-coil domain-containing protein 157	DEG_SPOP_SBC_1	643:647	AKSTS	SPOP	0.7532	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons