DegronMD - Q569K6(CCDC157)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D579N	TCGA-61-1727	OV	TCGA	DSGNVT	DEG_SCF_TRCP1_1	573:578	Mutation rewiring degron network	0.3056
p.D579N	DO29960	OV	ICGC	DSGNVT	DEG_SCF_TRCP1_1	573:578	Mutation rewiring degron network	0.3056
p.S645I	TCGA-AP-A0LM	UCEC	TCGA	AKSTS	DEG_SPOP_SBC_1	643:647	Mutation altering degron motif	0.8453
p.S645I	DO43306	UCEC	ICGC	AKSTS	DEG_SPOP_SBC_1	643:647	Mutation altering degron motif	0.8453
p.G652D	TCGA-AX-A2HC	UCEC	TCGA	AKSTS	DEG_SPOP_SBC_1	643:647	Mutation rewiring degron network	0.1944
p.G652D	DO41572	UCEC	ICGC	AKSTS	DEG_SPOP_SBC_1	643:647	Mutation rewiring degron network	0.1944
p.G649E	TCGA-GN-A269	SKCM	TCGA	AKSTS	DEG_SPOP_SBC_1	643:647	Mutation rewiring degron network	0.2778
p.G649E	DO37483	SKCM	ICGC	AKSTS	DEG_SPOP_SBC_1	643:647	Mutation rewiring degron network	0.2778
p.D579H	DO223000	BTCA	ICGC	DSGNVT	DEG_SCF_TRCP1_1	573:578	Mutation rewiring degron network	0.3056
p.Q586R	DO230309	COCA	ICGC	DSGNVT	DEG_SCF_TRCP1_1	573:578	Mutation rewiring degron network	0.1111
p.S587A	DO229010	COCA	ICGC	DSGNVT	DEG_SCF_TRCP1_1	573:578	Mutation rewiring degron network	0.0833
p.S587A	DO229013	COCA	ICGC	DSGNVT	DEG_SCF_TRCP1_1	573:578	Mutation rewiring degron network	0.0833
p.S587A	DO229016	COCA	ICGC	DSGNVT	DEG_SCF_TRCP1_1	573:578	Mutation rewiring degron network	0.0833
p.S587A	DO229003	COCA	ICGC	DSGNVT	DEG_SCF_TRCP1_1	573:578	Mutation rewiring degron network	0.0833
p.S587A	DO229005	COCA	ICGC	DSGNVT	DEG_SCF_TRCP1_1	573:578	Mutation rewiring degron network	0.0833
p.N588S	DO231967	LICA	ICGC	DSGNVT	DEG_SCF_TRCP1_1	573:578	Mutation rewiring degron network	0.0556
p.H655N	DO232016	ORCA	ICGC	AKSTS	DEG_SPOP_SBC_1	643:647	Mutation rewiring degron network	0.1111
p.P639T	SIDM01020	Plasma Cell Myeloma	GDSC	AKSTS	DEG_SPOP_SBC_1	643:647	Mutation rewiring degron network	0.2222
p.P639T	SIDM00328	Esophageal Squamous Cell Carcinoma	GDSC	AKSTS	DEG_SPOP_SBC_1	643:647	Mutation rewiring degron network	0.2222
p.P639T	SIDM00592	Oral Cavity Carcinoma	GDSC	AKSTS	DEG_SPOP_SBC_1	643:647	Mutation rewiring degron network	0.2222
p.P639T	SIDM00687	Gastric Carcinoma	GDSC	AKSTS	DEG_SPOP_SBC_1	643:647	Mutation rewiring degron network	0.2222
p.P639T	SIDM00487	Colorectal Carcinoma	GDSC	AKSTS	DEG_SPOP_SBC_1	643:647	Mutation rewiring degron network	0.2222
p.P639T	SIDM01210	Glioblastoma	GDSC	AKSTS	DEG_SPOP_SBC_1	643:647	Mutation rewiring degron network	0.2222
p.P639T	SIDM00380	Acute Myeloid Leukemia	GDSC	AKSTS	DEG_SPOP_SBC_1	643:647	Mutation rewiring degron network	0.2222
p.P639T	SIDM00289	B-Lymphoblastic Leukemia	GDSC	AKSTS	DEG_SPOP_SBC_1	643:647	Mutation rewiring degron network	0.2222
p.P639T	SIDM00274	Gastric Carcinoma	GDSC	AKSTS	DEG_SPOP_SBC_1	643:647	Mutation rewiring degron network	0.2222
p.P639T	SIDM00168	Head and Neck Carcinoma	GDSC	AKSTS	DEG_SPOP_SBC_1	643:647	Mutation rewiring degron network	0.2222
p.P639T	SIDM01470	Acute Myeloid Leukemia	GDSC	AKSTS	DEG_SPOP_SBC_1	643:647	Mutation rewiring degron network	0.2222
p.P639T	SIDM01471	Chronic Myelogenous Leukemia	GDSC	AKSTS	DEG_SPOP_SBC_1	643:647	Mutation rewiring degron network	0.2222
p.P639T	SIDM01434	Hepatocellular Carcinoma	GDSC	AKSTS	DEG_SPOP_SBC_1	643:647	Mutation rewiring degron network	0.2222
p.P639T	HAL-01	haematopoietic and lymphoid tissue	COSMIC	AKSTS	DEG_SPOP_SBC_1	643:647	Mutation rewiring degron network	0.2222
p.P639T	SKM-1	haematopoietic and lymphoid tissue	COSMIC	AKSTS	DEG_SPOP_SBC_1	643:647	Mutation rewiring degron network	0.2222
p.P639T	KATOIII	stomach	COSMIC	AKSTS	DEG_SPOP_SBC_1	643:647	Mutation rewiring degron network	0.2222
p.P639T	CCK-81	large intestine	COSMIC	AKSTS	DEG_SPOP_SBC_1	643:647	Mutation rewiring degron network	0.2222
p.P639T	GCIY	stomach	COSMIC	AKSTS	DEG_SPOP_SBC_1	643:647	Mutation rewiring degron network	0.2222
p.P639T	KNS-81-FD	central nervous system	COSMIC	AKSTS	DEG_SPOP_SBC_1	643:647	Mutation rewiring degron network	0.2222
p.P639T	KMS-12-BM	haematopoietic and lymphoid tissue	COSMIC	AKSTS	DEG_SPOP_SBC_1	643:647	Mutation rewiring degron network	0.2222
p.P639T	TE-6	oesophagus	COSMIC	AKSTS	DEG_SPOP_SBC_1	643:647	Mutation rewiring degron network	0.2222
p.P639T	HO-1-N-1	salivary gland	COSMIC	AKSTS	DEG_SPOP_SBC_1	643:647	Mutation rewiring degron network	0.2222
p.P650L	SIDM00195	Ewing's Sarcoma	GDSC	AKSTS	DEG_SPOP_SBC_1	643:647	Mutation rewiring degron network	0.25
p.V577I	SIDM00151	Ovarian Carcinoma	GDSC	DSGNVT	DEG_SCF_TRCP1_1	573:578	Mutation altering degron motif	0.5965
p.V577I	ACH-000966	Ovarian Cancer	CCLE	DSGNVT	DEG_SCF_TRCP1_1	573:578	Mutation altering degron motif	0.5965
p.V577I	IGROV-1	ovary	COSMIC	DSGNVT	DEG_SCF_TRCP1_1	573:578	Mutation altering degron motif	0.5965
p.V564M	SIDM00375	Head and Neck Carcinoma	GDSC	DSGNVT	DEG_SCF_TRCP1_1	573:578	Mutation rewiring degron network	0.0833
p.V564M	SIDM00502	B-Lymphoblastic Leukemia	GDSC	DSGNVT	DEG_SCF_TRCP1_1	573:578	Mutation rewiring degron network	0.0833
p.V564M	SIDM00431	T-Lymphoblastic Leukemia	GDSC	DSGNVT	DEG_SCF_TRCP1_1	573:578	Mutation rewiring degron network	0.0833
p.V564M	ACH-000157	Lymphoma	CCLE	DSGNVT	DEG_SCF_TRCP1_1	573:578	Mutation rewiring degron network	0.0833
p.V564M	ACH-000918	Leukemia	CCLE	DSGNVT	DEG_SCF_TRCP1_1	573:578	Mutation rewiring degron network	0.0833
p.V564M	ACH-002305	Head and Neck Cancer	CCLE	DSGNVT	DEG_SCF_TRCP1_1	573:578	Mutation rewiring degron network	0.0833
p.V564M	MOLT-16	haematopoietic and lymphoid tissue	COSMIC	DSGNVT	DEG_SCF_TRCP1_1	573:578	Mutation rewiring degron network	0.0833
p.V564M	A4-Fuk	haematopoietic and lymphoid tissue	COSMIC	DSGNVT	DEG_SCF_TRCP1_1	573:578	Mutation rewiring degron network	0.0833
p.V564M	SKN-3	upper aerodigestive tract	COSMIC	DSGNVT	DEG_SCF_TRCP1_1	573:578	Mutation rewiring degron network	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CCDC157

UniProt ID: Q569K6

Entrez ID: 550631

Protein name: Coiled-coil domain-containing protein 157

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CCDC157 in