DegronMD

Uniprot ID: Q569K6

Source protein: Coiled-coil domain-containing protein 157

Source gene: CCDC157

Class: DEG_SCF_TRCP1_1

Location: 573:578

E3 ligase: BTRC

DEGRON score: 0.996

ASA_SCORE: 79.1333

COIL: 0.715

CONS_SCORE: 0.4378

DSS_SCORE: 0.6347

HELIX: 0.2295

FCONS_SCORE: 1.2074

RIG_SCORE: 0.6408

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D579N	TCGA-61-1727	OV	TCGA	DSGNVT	DEG_SCF_TRCP1_1	0.3056
p.D579N	DO29960	OV	ICGC	DSGNVT	DEG_SCF_TRCP1_1	0.3056
p.D579H	DO223000	BTCA	ICGC	DSGNVT	DEG_SCF_TRCP1_1	0.3056
p.Q586R	DO230309	COCA	ICGC	DSGNVT	DEG_SCF_TRCP1_1	0.1111
p.S587A	DO229010	COCA	ICGC	DSGNVT	DEG_SCF_TRCP1_1	0.0833
p.S587A	DO229013	COCA	ICGC	DSGNVT	DEG_SCF_TRCP1_1	0.0833
p.S587A	DO229016	COCA	ICGC	DSGNVT	DEG_SCF_TRCP1_1	0.0833
p.S587A	DO229003	COCA	ICGC	DSGNVT	DEG_SCF_TRCP1_1	0.0833
p.S587A	DO229005	COCA	ICGC	DSGNVT	DEG_SCF_TRCP1_1	0.0833
p.N588S	DO231967	LICA	ICGC	DSGNVT	DEG_SCF_TRCP1_1	0.0556
p.V577I	SIDM00151	Ovarian Carcinoma	GDSC	DSGNVT	DEG_SCF_TRCP1_1	0.5965
p.V577I	ACH-000966	Ovarian Cancer	CCLE	DSGNVT	DEG_SCF_TRCP1_1	0.5965
p.V577I	IGROV-1	ovary	COSMIC	DSGNVT	DEG_SCF_TRCP1_1	0.5965
p.V564M	SIDM00375	Head and Neck Carcinoma	GDSC	DSGNVT	DEG_SCF_TRCP1_1	0.0833
p.V564M	SIDM00502	B-Lymphoblastic Leukemia	GDSC	DSGNVT	DEG_SCF_TRCP1_1	0.0833
p.V564M	SIDM00431	T-Lymphoblastic Leukemia	GDSC	DSGNVT	DEG_SCF_TRCP1_1	0.0833
p.V564M	ACH-000157	Lymphoma	CCLE	DSGNVT	DEG_SCF_TRCP1_1	0.0833
p.V564M	ACH-000918	Leukemia	CCLE	DSGNVT	DEG_SCF_TRCP1_1	0.0833
p.V564M	ACH-002305	Head and Neck Cancer	CCLE	DSGNVT	DEG_SCF_TRCP1_1	0.0833
p.V564M	MOLT-16	haematopoietic_and_lymphoid_tissue	COSMIC	DSGNVT	DEG_SCF_TRCP1_1	0.0833
p.V564M	A4-Fuk	haematopoietic_and_lymphoid_tissue	COSMIC	DSGNVT	DEG_SCF_TRCP1_1	0.0833
p.V564M	SKN-3	upper_aerodigestive_tract	COSMIC	DSGNVT	DEG_SCF_TRCP1_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q569K6	Coiled-coil domain-containing protein 157	DEG_SCF_TRCP1_1	573:578	DSGNVT	BTRC	0.996	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons