DegronMD

Uniprot ID: Q569K6

Source protein: Coiled-coil domain-containing protein 157

Source gene: CCDC157

Class: DEG_SPOP_SBC_1

Location: 643:647

E3 ligase: SPOP

DEGRON score: 0.7532

ASA_SCORE: 94.56

COIL: 0.939

CONS_SCORE: 0.2891

DSS_SCORE: 0.814

HELIX: 0.0268

FCONS_SCORE: 0.9401

RIG_SCORE: 0.5952

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S645I	TCGA-AP-A0LM	UCEC	TCGA	AKSTS	DEG_SPOP_SBC_1	0.8453
p.S645I	DO43306	UCEC	ICGC	AKSTS	DEG_SPOP_SBC_1	0.8453
p.G652D	TCGA-AX-A2HC	UCEC	TCGA	AKSTS	DEG_SPOP_SBC_1	0.1944
p.G652D	DO41572	UCEC	ICGC	AKSTS	DEG_SPOP_SBC_1	0.1944
p.G649E	TCGA-GN-A269	SKCM	TCGA	AKSTS	DEG_SPOP_SBC_1	0.2778
p.G649E	DO37483	SKCM	ICGC	AKSTS	DEG_SPOP_SBC_1	0.2778
p.H655N	DO232016	ORCA	ICGC	AKSTS	DEG_SPOP_SBC_1	0.1111
p.P639T	SIDM01020	Plasma Cell Myeloma	GDSC	AKSTS	DEG_SPOP_SBC_1	0.2222
p.P639T	SIDM00328	Esophageal Squamous Cell Carcinoma	GDSC	AKSTS	DEG_SPOP_SBC_1	0.2222
p.P639T	SIDM00592	Oral Cavity Carcinoma	GDSC	AKSTS	DEG_SPOP_SBC_1	0.2222
p.P639T	SIDM00687	Gastric Carcinoma	GDSC	AKSTS	DEG_SPOP_SBC_1	0.2222
p.P639T	SIDM00487	Colorectal Carcinoma	GDSC	AKSTS	DEG_SPOP_SBC_1	0.2222
p.P639T	SIDM01210	Glioblastoma	GDSC	AKSTS	DEG_SPOP_SBC_1	0.2222
p.P639T	SIDM00380	Acute Myeloid Leukemia	GDSC	AKSTS	DEG_SPOP_SBC_1	0.2222
p.P639T	SIDM00289	B-Lymphoblastic Leukemia	GDSC	AKSTS	DEG_SPOP_SBC_1	0.2222
p.P639T	SIDM00274	Gastric Carcinoma	GDSC	AKSTS	DEG_SPOP_SBC_1	0.2222
p.P639T	SIDM00168	Head and Neck Carcinoma	GDSC	AKSTS	DEG_SPOP_SBC_1	0.2222
p.P639T	SIDM01470	Acute Myeloid Leukemia	GDSC	AKSTS	DEG_SPOP_SBC_1	0.2222
p.P639T	SIDM01471	Chronic Myelogenous Leukemia	GDSC	AKSTS	DEG_SPOP_SBC_1	0.2222
p.P639T	SIDM01434	Hepatocellular Carcinoma	GDSC	AKSTS	DEG_SPOP_SBC_1	0.2222
p.P639T	HAL-01	haematopoietic_and_lymphoid_tissue	COSMIC	AKSTS	DEG_SPOP_SBC_1	0.2222
p.P639T	SKM-1	haematopoietic_and_lymphoid_tissue	COSMIC	AKSTS	DEG_SPOP_SBC_1	0.2222
p.P639T	KATOIII	stomach	COSMIC	AKSTS	DEG_SPOP_SBC_1	0.2222
p.P639T	CCK-81	large_intestine	COSMIC	AKSTS	DEG_SPOP_SBC_1	0.2222
p.P639T	GCIY	stomach	COSMIC	AKSTS	DEG_SPOP_SBC_1	0.2222
p.P639T	KNS-81-FD	central_nervous_system	COSMIC	AKSTS	DEG_SPOP_SBC_1	0.2222
p.P639T	KMS-12-BM	haematopoietic_and_lymphoid_tissue	COSMIC	AKSTS	DEG_SPOP_SBC_1	0.2222
p.P639T	TE-6	oesophagus	COSMIC	AKSTS	DEG_SPOP_SBC_1	0.2222
p.P639T	HO-1-N-1	salivary_gland	COSMIC	AKSTS	DEG_SPOP_SBC_1	0.2222
p.P650L	SIDM00195	Ewing's Sarcoma	GDSC	AKSTS	DEG_SPOP_SBC_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P49792	E3 SUMO-protein ligase RanBP2	DEG_SPOP_SBC_1	1951:1955	AKSTS	SPOP	0.8024	More...
P58304	Visual system homeobox 2	DEG_SPOP_SBC_1	18:22	AKSTS	SPOP	0.9689	More...
Q13480	GRB2-associated-binding protein 1	DEG_SPOP_SBC_1	204:208	AKSTS	SPOP	0.7361	More...
Q8WWL2	Protein spire homolog 2	DEG_SPOP_SBC_1	383:387	AKSTS	SPOP	0.6134	More...
Q9NSC2	Sal-like protein 1	DEG_SPOP_SBC_1	438:442	AKSTS	SPOP	0.9731	More...
A6NKT7	RanBP2-like and GRIP domain-containing protein 3	DEG_SPOP_SBC_1	976:980	AKSTS	SPOP	0.8902	More...
P0DJD0	RANBP2-like and GRIP domain-containing protein 1	DEG_SPOP_SBC_1	960:964	AKSTS	SPOP	0.9976	More...
P0DJD1	RANBP2-like and GRIP domain-containing protein 2	DEG_SPOP_SBC_1	968:972	AKSTS	SPOP	0.9478	More...
Q569K6	Coiled-coil domain-containing protein 157	DEG_SPOP_SBC_1	643:647	AKSTS	SPOP	0.7532	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: AKSTS

Degron related mutations and impact score

Drug responses associated with CCDC157 mutations

All proteins holding degron of AKSTS