DegronMD

Uniprot ID: P58304

Source protein: Visual system homeobox 2

Source gene: VSX2

Class: DEG_SPOP_SBC_1

Location: 18:22

E3 ligase: SPOP

DEGRON score: 0.9689

ASA_SCORE: 95.34

COIL: 0.9304

CONS_SCORE: 0.3722

DSS_SCORE: 0.5635

HELIX: 0.0458

FCONS_SCORE: 0.8518

RIG_SCORE: 0.6471

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A27T	TCGA-AD-6895	COAD	TCGA	AKSTS	DEG_SPOP_SBC_1	0.1944
p.A27T	DO8938	COAD	ICGC	AKSTS	DEG_SPOP_SBC_1	0.1944
p.T30A	TCGA-AU-6004	COAD	TCGA	AKSTS	DEG_SPOP_SBC_1	0.1111
p.T30A	DO7780	COAD	ICGC	AKSTS	DEG_SPOP_SBC_1	0.1111
p.A8V	TCGA-E6-A2P9	UCEC	TCGA	AKSTS	DEG_SPOP_SBC_1	0.0556
p.A8V	DO43714	UCEC	ICGC	AKSTS	DEG_SPOP_SBC_1	0.0556
p.A25P	TCGA-LN-A9FP	ESCA	TCGA	AKSTS	DEG_SPOP_SBC_1	0.25
p.A25T	DO51472	PACA	ICGC	AKSTS	DEG_SPOP_SBC_1	0.25
p.A8S	SIDM00120	Prostate Carcinoma	GDSC	AKSTS	DEG_SPOP_SBC_1	0.0556
p.A8S	ACH-000979	Prostate Cancer	CCLE	AKSTS	DEG_SPOP_SBC_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P49792	E3 SUMO-protein ligase RanBP2	DEG_SPOP_SBC_1	1951:1955	AKSTS	SPOP	0.8024	More...
P58304	Visual system homeobox 2	DEG_SPOP_SBC_1	18:22	AKSTS	SPOP	0.9689	More...
Q13480	GRB2-associated-binding protein 1	DEG_SPOP_SBC_1	204:208	AKSTS	SPOP	0.7361	More...
Q8WWL2	Protein spire homolog 2	DEG_SPOP_SBC_1	383:387	AKSTS	SPOP	0.6134	More...
Q9NSC2	Sal-like protein 1	DEG_SPOP_SBC_1	438:442	AKSTS	SPOP	0.9731	More...
A6NKT7	RanBP2-like and GRIP domain-containing protein 3	DEG_SPOP_SBC_1	976:980	AKSTS	SPOP	0.8902	More...
P0DJD0	RANBP2-like and GRIP domain-containing protein 1	DEG_SPOP_SBC_1	960:964	AKSTS	SPOP	0.9976	More...
P0DJD1	RANBP2-like and GRIP domain-containing protein 2	DEG_SPOP_SBC_1	968:972	AKSTS	SPOP	0.9478	More...
Q569K6	Coiled-coil domain-containing protein 157	DEG_SPOP_SBC_1	643:647	AKSTS	SPOP	0.7532	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons