DegronMD

Uniprot ID: P49792

Source protein: E3 SUMO-protein ligase RanBP2

Source gene: RANBP2

Class: DEG_SPOP_SBC_1

Location: 1951:1955

E3 ligase: SPOP

DEGRON score: 0.8024

ASA_SCORE: 73.58

COIL: 0.7396

CONS_SCORE: 0.3958

DSS_SCORE: 0.294

HELIX: 0.176

FCONS_SCORE: 0.9253

RIG_SCORE: 0.7363

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D1965Y	TCGA-B5-A1MR	UCEC	TCGA	AKSTS	DEG_SPOP_SBC_1	0.0556
p.D1965Y	DO41758	UCEC	ICGC	AKSTS	DEG_SPOP_SBC_1	0.0556
p.T1954I	TCGA-ZM-AA0D	TGCT	TCGA	AKSTS	DEG_SPOP_SBC_1	0.8189
p.F1961C	DO222285	GACA	ICGC	AKSTS	DEG_SPOP_SBC_1	0.1667
p.T1954S	DO49150	PACA	ICGC	AKSTS	DEG_SPOP_SBC_1	0.7116
p.F1961I	SIDM00889	Cervical Carcinoma	GDSC	AKSTS	DEG_SPOP_SBC_1	0.1667
p.F1961I	ACH-001333	Cervical Cancer	CCLE	AKSTS	DEG_SPOP_SBC_1	0.1667
p.F1961I	C-33-A	cervix	COSMIC	AKSTS	DEG_SPOP_SBC_1	0.1667
p.K1963I	SIDM00999	Bladder Carcinoma	GDSC	AKSTS	DEG_SPOP_SBC_1	0.5556
p.K1963I	ACH-000973	Bladder Cancer	CCLE	AKSTS	DEG_SPOP_SBC_1	0.5556
p.K1963I	639-V	urinary_tract	COSMIC	AKSTS	DEG_SPOP_SBC_1	0.5556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P49792	E3 SUMO-protein ligase RanBP2	DEG_SPOP_SBC_1	1951:1955	AKSTS	SPOP	0.8024	More...
P58304	Visual system homeobox 2	DEG_SPOP_SBC_1	18:22	AKSTS	SPOP	0.9689	More...
Q13480	GRB2-associated-binding protein 1	DEG_SPOP_SBC_1	204:208	AKSTS	SPOP	0.7361	More...
Q8WWL2	Protein spire homolog 2	DEG_SPOP_SBC_1	383:387	AKSTS	SPOP	0.6134	More...
Q9NSC2	Sal-like protein 1	DEG_SPOP_SBC_1	438:442	AKSTS	SPOP	0.9731	More...
A6NKT7	RanBP2-like and GRIP domain-containing protein 3	DEG_SPOP_SBC_1	976:980	AKSTS	SPOP	0.8902	More...
P0DJD0	RANBP2-like and GRIP domain-containing protein 1	DEG_SPOP_SBC_1	960:964	AKSTS	SPOP	0.9976	More...
P0DJD1	RANBP2-like and GRIP domain-containing protein 2	DEG_SPOP_SBC_1	968:972	AKSTS	SPOP	0.9478	More...
Q569K6	Coiled-coil domain-containing protein 157	DEG_SPOP_SBC_1	643:647	AKSTS	SPOP	0.7532	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons