DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
AKSTS
Uniprot ID:
P0DJD0
Source protein:
RANBP2-like and GRIP domain-containing protein 1
Source gene:
RGPD1
Class:
DEG_SPOP_SBC_1
Location:
960:964
E3 ligase:
SPOP
DEGRON score:
0.9976
ASA_SCORE:
72.3
COIL:
0.7586
CONS_SCORE:
0.328
DSS_SCORE:
0.2895
HELIX:
0.1466
FCONS_SCORE:
1.1038
RIG_SCORE:
0.7394
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with RGPD1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of AKSTS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
P49792
E3 SUMO-protein ligase RanBP2
DEG_SPOP_SBC_1
1951:1955
AKSTS
SPOP
0.8024
More...
P58304
Visual system homeobox 2
DEG_SPOP_SBC_1
18:22
AKSTS
SPOP
0.9689
More...
Q13480
GRB2-associated-binding protein 1
DEG_SPOP_SBC_1
204:208
AKSTS
SPOP
0.7361
More...
Q8WWL2
Protein spire homolog 2
DEG_SPOP_SBC_1
383:387
AKSTS
SPOP
0.6134
More...
Q9NSC2
Sal-like protein 1
DEG_SPOP_SBC_1
438:442
AKSTS
SPOP
0.9731
More...
A6NKT7
RanBP2-like and GRIP domain-containing protein 3
DEG_SPOP_SBC_1
976:980
AKSTS
SPOP
0.8902
More...
P0DJD0
RANBP2-like and GRIP domain-containing protein 1
DEG_SPOP_SBC_1
960:964
AKSTS
SPOP
0.9976
More...
P0DJD1
RANBP2-like and GRIP domain-containing protein 2
DEG_SPOP_SBC_1
968:972
AKSTS
SPOP
0.9478
More...
Q569K6
Coiled-coil domain-containing protein 157
DEG_SPOP_SBC_1
643:647
AKSTS
SPOP
0.7532
More...