DegronMD - A6NKT7(RGPD3)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D1261A	TCGA-13-2057	OV	TCGA	VSSSS	DEG_SPOP_SBC_1	1263:1267	Mutation rewiring degron network	0.2778
p.D1261A	DO31320	OV	ICGC	VSSSS	DEG_SPOP_SBC_1	1263:1267	Mutation rewiring degron network	0.2778
p.G987D	TCGA-3N-A9WC	SKCM	TCGA	AKSTS	DEG_SPOP_SBC_1	976:980	Mutation rewiring degron network	0.1389
p.G987D	TCGA-IB-7651	PAAD	TCGA	AKSTS	DEG_SPOP_SBC_1	976:980	Mutation rewiring degron network	0.1389
p.G987D	DO46657	PAAD	ICGC	AKSTS	DEG_SPOP_SBC_1	976:980	Mutation rewiring degron network	0.1389
p.G987D	DO51234	SKCM	ICGC	AKSTS	DEG_SPOP_SBC_1	976:980	Mutation rewiring degron network	0.1389
p.Y884H	TCGA-56-A62T	LUSC	TCGA	RPAANVTPT	DEG_SIAH_1	891:899	Mutation rewiring degron network	0.1389
p.Y884H	DO219144	LUSC	ICGC	RPAANVTPT	DEG_SIAH_1	891:899	Mutation rewiring degron network	0.1389
p.L1473S	TCGA-92-7341	LUSC	TCGA	LITPHVS	DEG_SCF_FBW7_1	1473:1479	Mutation altering degron motif	0.7667
p.L1473S	DO26677	LUSC	ICGC	LITPHVS	DEG_SCF_FBW7_1	1473:1479	Mutation altering degron motif	0.7667
p.A1532S	TCGA-A5-A0G2	UCEC	TCGA	VSSTS	DEG_SPOP_SBC_1	1522:1526	Mutation rewiring degron network	0.1667
p.A1532S	DO41235	UCEC	ICGC	VSSTS	DEG_SPOP_SBC_1	1522:1526	Mutation rewiring degron network	0.1667
p.S1472F	TCGA-A5-A0G2	UCEC	TCGA	LITPHVS	DEG_SCF_FBW7_1	1473:1479	Mutation blocking phosphorylation signal	0.75
p.S1472F	TCGA-EB-A3Y7	SKCM	TCGA	LITPHVS	DEG_SCF_FBW7_1	1473:1479	Mutation blocking phosphorylation signal	0.75
p.S1472F	DO37499	SKCM	ICGC	LITPHVS	DEG_SCF_FBW7_1	1473:1479	Mutation blocking phosphorylation signal	0.75
p.S1472F	DO41235	UCEC	ICGC	LITPHVS	DEG_SCF_FBW7_1	1473:1479	Mutation blocking phosphorylation signal	0.75
p.S1472Y	TCGA-A5-A0GP	UCEC	TCGA	LITPHVS	DEG_SCF_FBW7_1	1473:1479	Mutation blocking phosphorylation signal	0.75
p.S1472Y	TCGA-BS-A0TC	UCEC	TCGA	LITPHVS	DEG_SCF_FBW7_1	1473:1479	Mutation blocking phosphorylation signal	0.75
p.S1472Y	DO41109	UCEC	ICGC	LITPHVS	DEG_SCF_FBW7_1	1473:1479	Mutation blocking phosphorylation signal	0.75
p.S1472Y	DO42400	UCEC	ICGC	LITPHVS	DEG_SCF_FBW7_1	1473:1479	Mutation blocking phosphorylation signal	0.75
p.A1258D	TCGA-AP-A051	UCEC	TCGA	VSSSS	DEG_SPOP_SBC_1	1263:1267	Mutation rewiring degron network	0.1944
p.A1258D	TCGA-B5-A3FC	UCEC	TCGA	VSSSS	DEG_SPOP_SBC_1	1263:1267	Mutation rewiring degron network	0.1944
p.A1258D	DO41871	UCEC	ICGC	VSSSS	DEG_SPOP_SBC_1	1263:1267	Mutation rewiring degron network	0.1944
p.A1258D	DO42673	UCEC	ICGC	VSSSS	DEG_SPOP_SBC_1	1263:1267	Mutation rewiring degron network	0.1944
p.G901V	TCGA-AP-A1DK	UCEC	TCGA	RPAANVTPT	DEG_SIAH_1	891:899	Mutation rewiring degron network	0.2778
p.G901V	DO42033	UCEC	ICGC	RPAANVTPT	DEG_SIAH_1	891:899	Mutation rewiring degron network	0.2778
p.Y888H	TCGA-AX-A2HG	UCEC	TCGA	RPAANVTPT	DEG_SIAH_1	891:899	Mutation rewiring degron network	0.25
p.Y888H	DO41337	UCEC	ICGC	RPAANVTPT	DEG_SIAH_1	891:899	Mutation rewiring degron network	0.25
p.A894V	TCGA-B5-A0JY	UCEC	TCGA	RPAANVTPT	DEG_SIAH_1	891:899	Mutation altering degron motif	0.6936
p.A894V	DO43041	UCEC	ICGC	RPAANVTPT	DEG_SIAH_1	891:899	Mutation altering degron motif	0.6936
p.P882S	TCGA-B6-A0RV	BRCA	TCGA	RPAANVTPT	DEG_SIAH_1	891:899	Mutation rewiring degron network	0.0833
p.P882S	DO4167	BRCA	ICGC	RPAANVTPT	DEG_SIAH_1	891:899	Mutation rewiring degron network	0.0833
p.S1262N	TCGA-B6-A0X1	BRCA	TCGA	VSSSS	DEG_SPOP_SBC_1	1263:1267	Mutation blocking phosphorylation signal	0.75
p.S1262N	DO4854	BRCA	ICGC	VSSSS	DEG_SPOP_SBC_1	1263:1267	Mutation blocking phosphorylation signal	0.75
p.S978L	TCGA-BH-A0HF	BRCA	TCGA	AKSTS	DEG_SPOP_SBC_1	976:980	Mutation altering degron motif	0.8778
p.S978L	DO1749	BRCA	ICGC	AKSTS	DEG_SPOP_SBC_1	976:980	Mutation altering degron motif	0.8778
p.T979A	TCGA-BS-A0UJ	UCEC	TCGA	AKSTS	DEG_SPOP_SBC_1	976:980	Mutation altering degron motif	0.825
p.T979A	DO42745	UCEC	ICGC	AKSTS	DEG_SPOP_SBC_1	976:980	Mutation altering degron motif	0.825
p.G983E	TCGA-D3-A3MU	SKCM	TCGA	AKSTS	DEG_SPOP_SBC_1	976:980	Mutation rewiring degron network	0.25
p.G983E	TCGA-EB-A41B	SKCM	TCGA	AKSTS	DEG_SPOP_SBC_1	976:980	Mutation rewiring degron network	0.25
p.G983E	DO37611	SKCM	ICGC	AKSTS	DEG_SPOP_SBC_1	976:980	Mutation rewiring degron network	0.25
p.G983E	DO47337	SKCM	ICGC	AKSTS	DEG_SPOP_SBC_1	976:980	Mutation rewiring degron network	0.25
p.P898S	TCGA-EE-A182	SKCM	TCGA	RPAANVTPT	DEG_SIAH_1	891:899	Mutation altering degron motif	0.6752
p.P898S	TCGA-HU-8608	STAD	TCGA	RPAANVTPT	DEG_SIAH_1	891:899	Mutation altering degron motif	0.6752
p.P898S	DO37814	SKCM	ICGC	RPAANVTPT	DEG_SIAH_1	891:899	Mutation altering degron motif	0.6752
p.P898S	DO47841	STAD	ICGC	RPAANVTPT	DEG_SIAH_1	891:899	Mutation altering degron motif	0.6752
p.D1253N	TCGA-EE-A2GT	SKCM	TCGA	VSSSS	DEG_SPOP_SBC_1	1263:1267	Mutation rewiring degron network	0.0556
p.D1253N	DO37946	SKCM	ICGC	VSSSS	DEG_SPOP_SBC_1	1263:1267	Mutation rewiring degron network	0.0556
p.P898L	TCGA-EE-A2M5	SKCM	TCGA	RPAANVTPT	DEG_SIAH_1	891:899	Mutation altering degron motif	0.7582
p.P898L	DO37425	SKCM	ICGC	RPAANVTPT	DEG_SIAH_1	891:899	Mutation altering degron motif	0.7582
p.K989E	TCGA-EE-A2MJ	SKCM	TCGA	AKSTS	DEG_SPOP_SBC_1	976:980	Mutation substituting flanking lysine	0.1944
p.K989E	DO38099	SKCM	ICGC	AKSTS	DEG_SPOP_SBC_1	976:980	Mutation substituting flanking lysine	0.1944
p.E1256K	TCGA-EE-A3JA	SKCM	TCGA	VSSSS	DEG_SPOP_SBC_1	1263:1267	Mutation rewiring degron network	0.1389
p.E1256K	DO47625	SKCM	ICGC	VSSSS	DEG_SPOP_SBC_1	1263:1267	Mutation rewiring degron network	0.1389
p.E1256K	SIDM00401	Melanoma	GDSC	VSSSS	DEG_SPOP_SBC_1	1263:1267	Mutation rewiring degron network	0.1389
p.E1256K	ACH-000614	Skin Cancer	CCLE	VSSSS	DEG_SPOP_SBC_1	1263:1267	Mutation rewiring degron network	0.1389
p.E1256D	TCGA-FI-A2D6	UCEC	TCGA	VSSSS	DEG_SPOP_SBC_1	1263:1267	Mutation rewiring degron network	0.1389
p.E1256D	DO43867	UCEC	ICGC	VSSSS	DEG_SPOP_SBC_1	1263:1267	Mutation rewiring degron network	0.1389
p.L890F	TCGA-FR-A8YC	SKCM	TCGA	RPAANVTPT	DEG_SIAH_1	891:899	Mutation rewiring degron network	0.3056
p.L890F	DO50301	SKCM	ICGC	RPAANVTPT	DEG_SIAH_1	891:899	Mutation rewiring degron network	0.3056
p.E1256V	TCGA-FS-A1Z3	SKCM	TCGA	VSSSS	DEG_SPOP_SBC_1	1263:1267	Mutation rewiring degron network	0.1389
p.E1256V	DO37635	SKCM	ICGC	VSSSS	DEG_SPOP_SBC_1	1263:1267	Mutation rewiring degron network	0.1389
p.E1463K	TCGA-FW-A3R5	SKCM	TCGA	LITPHVS	DEG_SCF_FBW7_1	1473:1479	Mutation rewiring degron network	0.0556
p.E1463K	DO37406	SKCM	ICGC	LITPHVS	DEG_SCF_FBW7_1	1473:1479	Mutation rewiring degron network	0.0556
p.E1463K	SW684	soft tissue	COSMIC	LITPHVS	DEG_SCF_FBW7_1	1473:1479	Mutation rewiring degron network	0.0556
p.D1261N	TCGA-SY-A9G5	BLCA	TCGA	VSSSS	DEG_SPOP_SBC_1	1263:1267	Mutation rewiring degron network	0.2778
p.D1261N	DO51906	BLCA	ICGC	VSSSS	DEG_SPOP_SBC_1	1263:1267	Mutation rewiring degron network	0.2778
p.F970L	TCGA-UF-A7JO	HNSC	TCGA	AKSTS	DEG_SPOP_SBC_1	976:980	Mutation rewiring degron network	0.1667
p.F970L	DO219088	HNSC	ICGC	AKSTS	DEG_SPOP_SBC_1	976:980	Mutation rewiring degron network	0.1667
p.P1536S	DO231140	LAML	ICGC	VSSTS	DEG_SPOP_SBC_1	1522:1526	Mutation rewiring degron network	0.0556
p.P1536S	DO229024	LICA	ICGC	VSSTS	DEG_SPOP_SBC_1	1522:1526	Mutation rewiring degron network	0.0556
p.P1536S	DO229047	LICA	ICGC	VSSTS	DEG_SPOP_SBC_1	1522:1526	Mutation rewiring degron network	0.0556
p.P1536S	DO52365	LUSC	ICGC	VSSTS	DEG_SPOP_SBC_1	1522:1526	Mutation rewiring degron network	0.0556
p.P1536S	DO52366	LUSC	ICGC	VSSTS	DEG_SPOP_SBC_1	1522:1526	Mutation rewiring degron network	0.0556
p.P1536S	DO52389	LUSC	ICGC	VSSTS	DEG_SPOP_SBC_1	1522:1526	Mutation rewiring degron network	0.0556
p.G983R	DO229459	SKCA	ICGC	AKSTS	DEG_SPOP_SBC_1	976:980	Mutation rewiring degron network	0.25
p.K988N	DO218912	SKCA	ICGC	AKSTS	DEG_SPOP_SBC_1	976:980	Mutation blocking ubiquitination signal	0.5556
p.F986Y	SIDM00491	Thyroid Gland Carcinoma	GDSC	AKSTS	DEG_SPOP_SBC_1	976:980	Mutation rewiring degron network	0.1667
p.Y884C	SIDM00217	Colorectal Carcinoma	GDSC	RPAANVTPT	DEG_SIAH_1	891:899	Mutation rewiring degron network	0.1389
p.V896G	SIDM00951	T-Lymphoblastic Leukemia	GDSC	RPAANVTPT	DEG_SIAH_1	891:899	Mutation altering degron motif	0.7532
p.V896G	ACH-002222	Leukemia	CCLE	RPAANVTPT	DEG_SIAH_1	891:899	Mutation altering degron motif	0.7532
p.V896G	CTV-1	haematopoietic and lymphoid tissue	COSMIC	RPAANVTPT	DEG_SIAH_1	891:899	Mutation altering degron motif	0.7532
p.V890G	CTV-1	haematopoietic and lymphoid tissue	COSMIC	RPAANVTPT	DEG_SIAH_1	891:899	Mutation rewiring degron network	0.3056
p.H1477N	SNU-81	large intestine	COSMIC	LITPHVS	DEG_SCF_FBW7_1	1473:1479	Mutation altering degron motif	0.6312
p.L1276R	HT-115	large intestine	COSMIC	VSSSS	DEG_SPOP_SBC_1	1263:1267	Mutation blocking phosphorylation signal	0.5278
p.H1471N	SNU-81	large intestine	COSMIC	LITPHVS	DEG_SCF_FBW7_1	1473:1479	Mutation rewiring degron network	0.2778
p.E1469K	SW684	soft tissue	COSMIC	LITPHVS	DEG_SCF_FBW7_1	1473:1479	Mutation rewiring degron network	0.2222
p.S886Y	NCI-H1688	lung	COSMIC	RPAANVTPT	DEG_SIAH_1	891:899	Mutation rewiring degron network	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RGPD3

UniProt ID: A6NKT7

Entrez ID: 653489

Protein name: RanBP2-like and GRIP domain-containing protein 3

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for RGPD3 in