DegronMD

Uniprot ID: A6NKT7

Source protein: RanBP2-like and GRIP domain-containing protein 3

Source gene: RGPD3

Class: DEG_SCF_FBW7_1

Location: 1473:1479

E3 ligase: FBXW7

DEGRON score: 0.8721

ASA_SCORE: 100.7857

COIL: 0.8867

CONS_SCORE: 0.3315

DSS_SCORE: 0.5874

HELIX: 0.0303

FCONS_SCORE: 1.1718

RIG_SCORE: 0.7028

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L1473S	TCGA-92-7341	LUSC	TCGA	LITPHVS	DEG_SCF_FBW7_1	0.7667
p.L1473S	DO26677	LUSC	ICGC	LITPHVS	DEG_SCF_FBW7_1	0.7667
p.S1472F	TCGA-A5-A0G2	UCEC	TCGA	LITPHVS	DEG_SCF_FBW7_1	0.75
p.S1472F	TCGA-EB-A3Y7	SKCM	TCGA	LITPHVS	DEG_SCF_FBW7_1	0.75
p.S1472F	DO37499	SKCM	ICGC	LITPHVS	DEG_SCF_FBW7_1	0.75
p.S1472F	DO41235	UCEC	ICGC	LITPHVS	DEG_SCF_FBW7_1	0.75
p.S1472Y	TCGA-A5-A0GP	UCEC	TCGA	LITPHVS	DEG_SCF_FBW7_1	0.75
p.S1472Y	TCGA-BS-A0TC	UCEC	TCGA	LITPHVS	DEG_SCF_FBW7_1	0.75
p.S1472Y	DO41109	UCEC	ICGC	LITPHVS	DEG_SCF_FBW7_1	0.75
p.S1472Y	DO42400	UCEC	ICGC	LITPHVS	DEG_SCF_FBW7_1	0.75
p.E1463K	TCGA-FW-A3R5	SKCM	TCGA	LITPHVS	DEG_SCF_FBW7_1	0.0556
p.E1463K	DO37406	SKCM	ICGC	LITPHVS	DEG_SCF_FBW7_1	0.0556
p.E1463K	SW684	soft_tissue	COSMIC	LITPHVS	DEG_SCF_FBW7_1	0.0556
p.H1477N	SNU-81	large_intestine	COSMIC	LITPHVS	DEG_SCF_FBW7_1	0.6312
p.H1471N	SNU-81	large_intestine	COSMIC	LITPHVS	DEG_SCF_FBW7_1	0.2778
p.E1469K	SW684	soft_tissue	COSMIC	LITPHVS	DEG_SCF_FBW7_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P49792	E3 SUMO-protein ligase RanBP2	DEG_SCF_FBW7_1	2448:2454	LITPHVS	FBXW7	0.9319	More...
Q99666	RANBP2-like and GRIP domain-containing protein 5/6	DEG_SCF_FBW7_1	1472:1478	LITPHVS	FBXW7	0.9475	More...
A6NKT7	RanBP2-like and GRIP domain-containing protein 3	DEG_SCF_FBW7_1	1473:1479	LITPHVS	FBXW7	0.8721	More...
O14715	RANBP2-like and GRIP domain-containing protein 8	DEG_SCF_FBW7_1	1472:1478	LITPHVS	FBXW7	0.9085	More...
P0DJD0	RANBP2-like and GRIP domain-containing protein 1	DEG_SCF_FBW7_1	1457:1463	LITPHVS	FBXW7	0.8406	More...
P0DJD1	RANBP2-like and GRIP domain-containing protein 2	DEG_SCF_FBW7_1	1465:1471	LITPHVS	FBXW7	0.8004	More...
Q7Z3J3	RanBP2-like and GRIP domain-containing protein 4	DEG_SCF_FBW7_1	1473:1479	LITPHVS	FBXW7	0.9808	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons