DegronMD

Uniprot ID: O14715

Source protein: RANBP2-like and GRIP domain-containing protein 8

Source gene: RGPD8

Class: DEG_SCF_FBW7_1

Location: 1472:1478

E3 ligase: FBXW7

DEGRON score: 0.9085

ASA_SCORE: 101.2714

COIL: 0.8663

CONS_SCORE: 0.3282

DSS_SCORE: 0.5838

HELIX: 0.0387

FCONS_SCORE: 1.1839

RIG_SCORE: 0.7059

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1486T	TCGA-B8-5550	KIRC	TCGA	LITPHVS	DEG_SCF_FBW7_1	0.5556
p.E1485D	TCGA-B8-5550	KIRC	TCGA	LITPHVS	DEG_SCF_FBW7_1	0.1389
p.R1484K	TCGA-CV-A6K1	HNSC	TCGA	LITPHVS	DEG_SCF_FBW7_1	0.1667
p.S1471Y	TCGA-EO-A22X	UCEC	TCGA	LITPHVS	DEG_SCF_FBW7_1	0.75

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P49792	E3 SUMO-protein ligase RanBP2	DEG_SCF_FBW7_1	2448:2454	LITPHVS	FBXW7	0.9319	More...
Q99666	RANBP2-like and GRIP domain-containing protein 5/6	DEG_SCF_FBW7_1	1472:1478	LITPHVS	FBXW7	0.9475	More...
A6NKT7	RanBP2-like and GRIP domain-containing protein 3	DEG_SCF_FBW7_1	1473:1479	LITPHVS	FBXW7	0.8721	More...
O14715	RANBP2-like and GRIP domain-containing protein 8	DEG_SCF_FBW7_1	1472:1478	LITPHVS	FBXW7	0.9085	More...
P0DJD0	RANBP2-like and GRIP domain-containing protein 1	DEG_SCF_FBW7_1	1457:1463	LITPHVS	FBXW7	0.8406	More...
P0DJD1	RANBP2-like and GRIP domain-containing protein 2	DEG_SCF_FBW7_1	1465:1471	LITPHVS	FBXW7	0.8004	More...
Q7Z3J3	RanBP2-like and GRIP domain-containing protein 4	DEG_SCF_FBW7_1	1473:1479	LITPHVS	FBXW7	0.9808	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons