DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
LITPHVS
Uniprot ID:
Q99666
Source protein:
RANBP2-like and GRIP domain-containing protein 5/6
Source gene:
RGPD5; RGPD6
Class:
DEG_SCF_FBW7_1
Location:
1472:1478
E3 ligase:
FBXW7
DEGRON score:
0.9475
ASA_SCORE:
98.2571
COIL:
0.8713
CONS_SCORE:
0.3123
DSS_SCORE:
0.5881
HELIX:
0.0351
FCONS_SCORE:
1.09
RIG_SCORE:
0.7033
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with RGPD5; RGPD6 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of LITPHVS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
P49792
E3 SUMO-protein ligase RanBP2
DEG_SCF_FBW7_1
2448:2454
LITPHVS
FBXW7
0.9319
More...
Q99666
RANBP2-like and GRIP domain-containing protein 5/6
DEG_SCF_FBW7_1
1472:1478
LITPHVS
FBXW7
0.9475
More...
A6NKT7
RanBP2-like and GRIP domain-containing protein 3
DEG_SCF_FBW7_1
1473:1479
LITPHVS
FBXW7
0.8721
More...
O14715
RANBP2-like and GRIP domain-containing protein 8
DEG_SCF_FBW7_1
1472:1478
LITPHVS
FBXW7
0.9085
More...
P0DJD0
RANBP2-like and GRIP domain-containing protein 1
DEG_SCF_FBW7_1
1457:1463
LITPHVS
FBXW7
0.8406
More...
P0DJD1
RANBP2-like and GRIP domain-containing protein 2
DEG_SCF_FBW7_1
1465:1471
LITPHVS
FBXW7
0.8004
More...
Q7Z3J3
RanBP2-like and GRIP domain-containing protein 4
DEG_SCF_FBW7_1
1473:1479
LITPHVS
FBXW7
0.9808
More...