DegronMD

Uniprot ID: Q7Z3J3

Source protein: RanBP2-like and GRIP domain-containing protein 4

Source gene: RGPD4

Class: DEG_SCF_FBW7_1

Location: 1473:1479

E3 ligase: FBXW7

DEGRON score: 0.9808

ASA_SCORE: 102.6

COIL: 0.91

CONS_SCORE: 0.2155

DSS_SCORE: 0.5874

HELIX: 0.0301

FCONS_SCORE: 0.8247

RIG_SCORE: 0.7028

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1472Y	TCGA-AX-A06F	UCEC	TCGA	LITPHVS	DEG_SCF_FBW7_1	0.75
p.S1472Y	TCGA-BK-A6W3	UCEC	TCGA	LITPHVS	DEG_SCF_FBW7_1	0.75
p.S1472Y	DO50076	UCEC	ICGC	LITPHVS	DEG_SCF_FBW7_1	0.75
p.S1472Y	DO41752	UCEC	ICGC	LITPHVS	DEG_SCF_FBW7_1	0.75
p.S1482N	TCGA-LN-A8HZ	ESCA	TCGA	LITPHVS	DEG_SCF_FBW7_1	0.6944
p.E1469K	TCGA-D3-A8GV	SKCM	TCGA	LITPHVS	DEG_SCF_FBW7_1	0.2222
p.E1469K	DO219477	SKCM	ICGC	LITPHVS	DEG_SCF_FBW7_1	0.2222
p.R1485T	TCGA-66-2785	LUSC	TCGA	LITPHVS	DEG_SCF_FBW7_1	0.1667
p.R1485T	DO26520	LUSC	ICGC	LITPHVS	DEG_SCF_FBW7_1	0.1667

Showing 1 to 9 of 9 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P49792	E3 SUMO-protein ligase RanBP2	DEG_SCF_FBW7_1	2448:2454	LITPHVS	FBXW7	0.9319	More...
P0DJD0	RANBP2-like and GRIP domain-containing protein 1	DEG_SCF_FBW7_1	1457:1463	LITPHVS	FBXW7	0.8406	More...
P0DJD1	RANBP2-like and GRIP domain-containing protein 2	DEG_SCF_FBW7_1	1465:1471	LITPHVS	FBXW7	0.8004	More...
A6NKT7	RanBP2-like and GRIP domain-containing protein 3	DEG_SCF_FBW7_1	1473:1479	LITPHVS	FBXW7	0.8721	More...
Q7Z3J3	RanBP2-like and GRIP domain-containing protein 4	DEG_SCF_FBW7_1	1473:1479	LITPHVS	FBXW7	0.9808	More...
Q99666	RANBP2-like and GRIP domain-containing protein 5/6	DEG_SCF_FBW7_1	1472:1478	LITPHVS	FBXW7	0.9475	More...
O14715	RANBP2-like and GRIP domain-containing protein 8	DEG_SCF_FBW7_1	1472:1478	LITPHVS	FBXW7	0.9085	More...

Showing 1 to 7 of 7 entries

DegronMD: protein-targeted degradation, mutation and drug response to degrons