DegronMD - Q7Z3J3(RGPD4)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E1256D	TCGA-2H-A9GM	ESCA	TCGA	VSSSS	DEG_SPOP_SBC_1	1263:1267	Mutation rewiring degron network	0.1389
p.A1532S	TCGA-50-5072	LUAD	TCGA	VSSTS	DEG_SPOP_SBC_1	1522:1526	Mutation rewiring degron network	0.1667
p.A1532S	DO25967	LUAD	ICGC	VSSTS	DEG_SPOP_SBC_1	1522:1526	Mutation rewiring degron network	0.1667
p.R1485T	TCGA-66-2785	LUSC	TCGA	LITPHVS	DEG_SCF_FBW7_1	1473:1479	Mutation rewiring degron network	0.1667
p.R1485T	DO26520	LUSC	ICGC	LITPHVS	DEG_SCF_FBW7_1	1473:1479	Mutation rewiring degron network	0.1667
p.G901C	TCGA-78-7146	LUAD	TCGA	RPAANVTPT	DEG_SIAH_1	891:899	Mutation rewiring degron network	0.2778
p.G901C	DO23717	LUAD	ICGC	RPAANVTPT	DEG_SIAH_1	891:899	Mutation rewiring degron network	0.2778
p.S1264I	TCGA-91-A4BC	LUAD	TCGA	VSSSS	DEG_SPOP_SBC_1	1263:1267	Mutation altering degron motif	0.7341
p.S1264I	DO45422	LUAD	ICGC	VSSSS	DEG_SPOP_SBC_1	1263:1267	Mutation altering degron motif	0.7341
p.S1271Y	TCGA-A5-A2K5	UCEC	TCGA	VSSSS	DEG_SPOP_SBC_1	1263:1267	Mutation blocking phosphorylation signal	0.6667
p.S1271Y	DO41379	UCEC	ICGC	VSSSS	DEG_SPOP_SBC_1	1263:1267	Mutation blocking phosphorylation signal	0.6667
p.S1535Y	TCGA-AJ-A3EL	UCEC	TCGA	VSSTS	DEG_SPOP_SBC_1	1522:1526	Mutation blocking phosphorylation signal	0.5278
p.S1535Y	DO41542	UCEC	ICGC	VSSTS	DEG_SPOP_SBC_1	1522:1526	Mutation blocking phosphorylation signal	0.5278
p.S1472Y	TCGA-AX-A06F	UCEC	TCGA	LITPHVS	DEG_SCF_FBW7_1	1473:1479	Mutation blocking phosphorylation signal	0.75
p.S1472Y	TCGA-BK-A6W3	UCEC	TCGA	LITPHVS	DEG_SCF_FBW7_1	1473:1479	Mutation blocking phosphorylation signal	0.75
p.S1472Y	DO50076	UCEC	ICGC	LITPHVS	DEG_SCF_FBW7_1	1473:1479	Mutation blocking phosphorylation signal	0.75
p.S1472Y	DO41752	UCEC	ICGC	LITPHVS	DEG_SCF_FBW7_1	1473:1479	Mutation blocking phosphorylation signal	0.75
p.A1258T	TCGA-AX-A0J1	UCEC	TCGA	VSSSS	DEG_SPOP_SBC_1	1263:1267	Mutation rewiring degron network	0.1944
p.A1258T	DO41199	UCEC	ICGC	VSSSS	DEG_SPOP_SBC_1	1263:1267	Mutation rewiring degron network	0.1944
p.E1256K	TCGA-CV-6943	HNSC	TCGA	VSSSS	DEG_SPOP_SBC_1	1263:1267	Mutation rewiring degron network	0.1389
p.E1256K	DO15511	HNSC	ICGC	VSSSS	DEG_SPOP_SBC_1	1263:1267	Mutation rewiring degron network	0.1389
p.T1528I	TCGA-D1-A17Q	UCEC	TCGA	VSSTS	DEG_SPOP_SBC_1	1522:1526	Mutation blocking phosphorylation signal	0.7222
p.T1528I	DO41903	UCEC	ICGC	VSSTS	DEG_SPOP_SBC_1	1522:1526	Mutation blocking phosphorylation signal	0.7222
p.E1469K	TCGA-D3-A8GV	SKCM	TCGA	LITPHVS	DEG_SCF_FBW7_1	1473:1479	Mutation rewiring degron network	0.2222
p.E1469K	DO219477	SKCM	ICGC	LITPHVS	DEG_SCF_FBW7_1	1473:1479	Mutation rewiring degron network	0.2222
p.A1517T	TCGA-EE-A2GN	SKCM	TCGA	VSSTS	DEG_SPOP_SBC_1	1522:1526	Mutation rewiring degron network	0.1944
p.A1517T	DO37896	SKCM	ICGC	VSSTS	DEG_SPOP_SBC_1	1522:1526	Mutation rewiring degron network	0.1944
p.P1536H	TCGA-EO-A3B0	UCEC	TCGA	VSSTS	DEG_SPOP_SBC_1	1522:1526	Mutation rewiring degron network	0.0556
p.P1536H	DO219773	UCEC	ICGC	VSSTS	DEG_SPOP_SBC_1	1522:1526	Mutation rewiring degron network	0.0556
p.S1264N	TCGA-FD-A3SQ	BLCA	TCGA	VSSSS	DEG_SPOP_SBC_1	1263:1267	Mutation altering degron motif	0.7069
p.S1264N	DO462	BLCA	ICGC	VSSSS	DEG_SPOP_SBC_1	1263:1267	Mutation altering degron motif	0.7069
p.S1482N	TCGA-LN-A8HZ	ESCA	TCGA	LITPHVS	DEG_SCF_FBW7_1	1473:1479	Mutation blocking phosphorylation signal	0.6944
p.E1519K	TCGA-YD-A89C	SKCM	TCGA	VSSTS	DEG_SPOP_SBC_1	1522:1526	Mutation rewiring degron network	0.25
p.E1519K	DO219501	SKCM	ICGC	VSSTS	DEG_SPOP_SBC_1	1522:1526	Mutation rewiring degron network	0.25
p.P1536S	DO52342	LUSC	ICGC	VSSTS	DEG_SPOP_SBC_1	1522:1526	Mutation rewiring degron network	0.0556
p.P1536S	DO52385	LUSC	ICGC	VSSTS	DEG_SPOP_SBC_1	1522:1526	Mutation rewiring degron network	0.0556
p.P1536S	DO52388	LUSC	ICGC	VSSTS	DEG_SPOP_SBC_1	1522:1526	Mutation rewiring degron network	0.0556
p.P1272L	DO220851	MELA	ICGC	VSSSS	DEG_SPOP_SBC_1	1263:1267	Mutation rewiring degron network	0.1944
p.S886F	DO228017	SKCA	ICGC	RPAANVTPT	DEG_SIAH_1	891:899	Mutation rewiring degron network	0.1944
p.D1253N	SIDM00527	Colorectal Carcinoma	GDSC	VSSSS	DEG_SPOP_SBC_1	1263:1267	Mutation rewiring degron network	0.0556
p.D1253N	ACH-000935	Colon/Colorectal Cancer	CCLE	VSSSS	DEG_SPOP_SBC_1	1263:1267	Mutation rewiring degron network	0.0556
p.D1253N	MDST8	large intestine	COSMIC	VSSSS	DEG_SPOP_SBC_1	1263:1267	Mutation rewiring degron network	0.0556
p.T1530P	ST486	haematopoietic and lymphoid tissue	COSMIC	VSSTS	DEG_SPOP_SBC_1	1522:1526	Mutation blocking phosphorylation signal	0.6667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RGPD4

UniProt ID: Q7Z3J3

Entrez ID: 285190

Protein name: RanBP2-like and GRIP domain-containing protein 4

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for RGPD4 in