DegronMD

Uniprot ID: Q7Z3J3

Source protein: RanBP2-like and GRIP domain-containing protein 4

Source gene: RGPD4

Class: DEG_SIAH_1

Location: 891:899

E3 ligase: SIAH1,SIAH2,SIAH3

DEGRON score: 0.9992

ASA_SCORE: 81.6333

COIL: 0.8304

CONS_SCORE: 0.3071

DSS_SCORE: 0.4497

HELIX: 0.0342

FCONS_SCORE: 1.0769

RIG_SCORE: 0.7341

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G901C	TCGA-78-7146	LUAD	TCGA	RPAANVTPT	DEG_SIAH_1	0.2778
p.G901C	DO23717	LUAD	ICGC	RPAANVTPT	DEG_SIAH_1	0.2778
p.S886F	DO228017	SKCA	ICGC	RPAANVTPT	DEG_SIAH_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P49792	E3 SUMO-protein ligase RanBP2	DEG_SIAH_1	890:898	RPAANVTPT	SIAH1,SIAH2,SIAH3	0.9981	More...
Q99666	RANBP2-like and GRIP domain-containing protein 5/6	DEG_SIAH_1	890:898	RPAANVTPT	SIAH1,SIAH2,SIAH3	0.9902	More...
A6NKT7	RanBP2-like and GRIP domain-containing protein 3	DEG_SIAH_1	891:899	RPAANVTPT	SIAH1,SIAH2,SIAH3	0.9985	More...
O14715	RANBP2-like and GRIP domain-containing protein 8	DEG_SIAH_1	890:898	RPAANVTPT	SIAH1,SIAH2,SIAH3	0.9902	More...
P0DJD0	RANBP2-like and GRIP domain-containing protein 1	DEG_SIAH_1	875:883	RPAANVTPT	SIAH1,SIAH2,SIAH3	0.9983	More...
P0DJD1	RANBP2-like and GRIP domain-containing protein 2	DEG_SIAH_1	883:891	RPAANVTPT	SIAH1,SIAH2,SIAH3	0.9973	More...
Q7Z3J3	RanBP2-like and GRIP domain-containing protein 4	DEG_SIAH_1	891:899	RPAANVTPT	SIAH1,SIAH2,SIAH3	0.9992	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons