DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
RPAANVTPT
Uniprot ID:
O14715
Source protein:
RANBP2-like and GRIP domain-containing protein 8
Source gene:
RGPD8
Class:
DEG_SIAH_1
Location:
890:898
E3 ligase:
SIAH1,SIAH2,SIAH3
DEGRON score:
0.9902
ASA_SCORE:
83
COIL:
0.8569
CONS_SCORE:
0.2841
DSS_SCORE:
0.4497
HELIX:
0.0473
FCONS_SCORE:
0.7617
RIG_SCORE:
0.7341
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.N894S
TCGA-19-5956
GBM
TCGA
RPAANVTPT
DEG_SIAH_1
0.5958
Drug responses associated with RGPD8 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of RPAANVTPT
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
P49792
E3 SUMO-protein ligase RanBP2
DEG_SIAH_1
890:898
RPAANVTPT
SIAH1,SIAH2,SIAH3
0.9981
More...
Q99666
RANBP2-like and GRIP domain-containing protein 5/6
DEG_SIAH_1
890:898
RPAANVTPT
SIAH1,SIAH2,SIAH3
0.9902
More...
A6NKT7
RanBP2-like and GRIP domain-containing protein 3
DEG_SIAH_1
891:899
RPAANVTPT
SIAH1,SIAH2,SIAH3
0.9985
More...
O14715
RANBP2-like and GRIP domain-containing protein 8
DEG_SIAH_1
890:898
RPAANVTPT
SIAH1,SIAH2,SIAH3
0.9902
More...
P0DJD0
RANBP2-like and GRIP domain-containing protein 1
DEG_SIAH_1
875:883
RPAANVTPT
SIAH1,SIAH2,SIAH3
0.9983
More...
P0DJD1
RANBP2-like and GRIP domain-containing protein 2
DEG_SIAH_1
883:891
RPAANVTPT
SIAH1,SIAH2,SIAH3
0.9973
More...
Q7Z3J3
RanBP2-like and GRIP domain-containing protein 4
DEG_SIAH_1
891:899
RPAANVTPT
SIAH1,SIAH2,SIAH3
0.9992
More...