DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
RPAANVTPT
Uniprot ID:
P0DJD1
Source protein:
RANBP2-like and GRIP domain-containing protein 2
Source gene:
RGPD2
Class:
DEG_SIAH_1
Location:
883:891
E3 ligase:
SIAH1,SIAH2,SIAH3
DEGRON score:
0.9973
ASA_SCORE:
78.4333
COIL:
0.8279
CONS_SCORE:
0.3187
DSS_SCORE:
0.4407
HELIX:
0.0499
FCONS_SCORE:
0.9873
RIG_SCORE:
0.7413
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.L882V
TCGA-AN-A0AR
BRCA
TCGA
RPAANVTPT
DEG_SIAH_1
0.3056
p.L882V
DO4731
BRCA
ICGC
RPAANVTPT
DEG_SIAH_1
0.3056
Drug responses associated with RGPD2 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of RPAANVTPT
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
P49792
E3 SUMO-protein ligase RanBP2
DEG_SIAH_1
890:898
RPAANVTPT
SIAH1,SIAH2,SIAH3
0.9981
More...
Q99666
RANBP2-like and GRIP domain-containing protein 5/6
DEG_SIAH_1
890:898
RPAANVTPT
SIAH1,SIAH2,SIAH3
0.9902
More...
A6NKT7
RanBP2-like and GRIP domain-containing protein 3
DEG_SIAH_1
891:899
RPAANVTPT
SIAH1,SIAH2,SIAH3
0.9985
More...
O14715
RANBP2-like and GRIP domain-containing protein 8
DEG_SIAH_1
890:898
RPAANVTPT
SIAH1,SIAH2,SIAH3
0.9902
More...
P0DJD0
RANBP2-like and GRIP domain-containing protein 1
DEG_SIAH_1
875:883
RPAANVTPT
SIAH1,SIAH2,SIAH3
0.9983
More...
P0DJD1
RANBP2-like and GRIP domain-containing protein 2
DEG_SIAH_1
883:891
RPAANVTPT
SIAH1,SIAH2,SIAH3
0.9973
More...
Q7Z3J3
RanBP2-like and GRIP domain-containing protein 4
DEG_SIAH_1
891:899
RPAANVTPT
SIAH1,SIAH2,SIAH3
0.9992
More...