DegronMD

Uniprot ID: P49792

Source protein: E3 SUMO-protein ligase RanBP2

Source gene: RANBP2

Class: DEG_SIAH_1

Location: 890:898

E3 ligase: SIAH1,SIAH2,SIAH3

DEGRON score: 0.9981

ASA_SCORE: 70.0778

COIL: 0.8679

CONS_SCORE: 0.3578

DSS_SCORE: 0.3853

HELIX: 0.0913

FCONS_SCORE: 0.8775

RIG_SCORE: 0.7328

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N906S	TCGA-46-3768	LUSC	TCGA	RPAANVTPT	DEG_SIAH_1	0.1111
p.N906S	DO26466	LUSC	ICGC	RPAANVTPT	DEG_SIAH_1	0.1111
p.M905V	TCGA-85-8479	LUSC	TCGA	RPAANVTPT	DEG_SIAH_1	0.1389
p.M905V	DO45443	LUSC	ICGC	RPAANVTPT	DEG_SIAH_1	0.1389
p.P901S	TCGA-GN-A26C	SKCM	TCGA	RPAANVTPT	DEG_SIAH_1	0.25
p.P901S	DO37782	SKCM	ICGC	RPAANVTPT	DEG_SIAH_1	0.25
p.M905I	DO222798	COCA	ICGC	RPAANVTPT	DEG_SIAH_1	0.1389
p.M905T	SIDM00980	Gastric Carcinoma	GDSC	RPAANVTPT	DEG_SIAH_1	0.1389
p.M905T	ACH-000948	Gastric Cancer	CCLE	RPAANVTPT	DEG_SIAH_1	0.1389
p.M905T	23132-87	stomach	COSMIC	RPAANVTPT	DEG_SIAH_1	0.1389
p.V902G	ACH-000079	Non-Cancerous	CCLE	RPAANVTPT	DEG_SIAH_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P49792	E3 SUMO-protein ligase RanBP2	DEG_SIAH_1	890:898	RPAANVTPT	SIAH1,SIAH2,SIAH3	0.9981	More...
Q99666	RANBP2-like and GRIP domain-containing protein 5/6	DEG_SIAH_1	890:898	RPAANVTPT	SIAH1,SIAH2,SIAH3	0.9902	More...
A6NKT7	RanBP2-like and GRIP domain-containing protein 3	DEG_SIAH_1	891:899	RPAANVTPT	SIAH1,SIAH2,SIAH3	0.9985	More...
O14715	RANBP2-like and GRIP domain-containing protein 8	DEG_SIAH_1	890:898	RPAANVTPT	SIAH1,SIAH2,SIAH3	0.9902	More...
P0DJD0	RANBP2-like and GRIP domain-containing protein 1	DEG_SIAH_1	875:883	RPAANVTPT	SIAH1,SIAH2,SIAH3	0.9983	More...
P0DJD1	RANBP2-like and GRIP domain-containing protein 2	DEG_SIAH_1	883:891	RPAANVTPT	SIAH1,SIAH2,SIAH3	0.9973	More...
Q7Z3J3	RanBP2-like and GRIP domain-containing protein 4	DEG_SIAH_1	891:899	RPAANVTPT	SIAH1,SIAH2,SIAH3	0.9992	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons