DegronMD

Uniprot ID: A6NKT7

Source protein: RanBP2-like and GRIP domain-containing protein 3

Source gene: RGPD3

Class: DEG_SIAH_1

Location: 891:899

E3 ligase: SIAH1,SIAH2,SIAH3

DEGRON score: 0.9985

ASA_SCORE: 80.7667

COIL: 0.8719

CONS_SCORE: 0.278

DSS_SCORE: 0.4497

HELIX: 0.0593

FCONS_SCORE: 0.8571

RIG_SCORE: 0.7341

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Y884H	TCGA-56-A62T	LUSC	TCGA	RPAANVTPT	DEG_SIAH_1	0.1389
p.Y884H	DO219144	LUSC	ICGC	RPAANVTPT	DEG_SIAH_1	0.1389
p.G901V	TCGA-AP-A1DK	UCEC	TCGA	RPAANVTPT	DEG_SIAH_1	0.2778
p.G901V	DO42033	UCEC	ICGC	RPAANVTPT	DEG_SIAH_1	0.2778
p.Y888H	TCGA-AX-A2HG	UCEC	TCGA	RPAANVTPT	DEG_SIAH_1	0.25
p.Y888H	DO41337	UCEC	ICGC	RPAANVTPT	DEG_SIAH_1	0.25
p.A894V	TCGA-B5-A0JY	UCEC	TCGA	RPAANVTPT	DEG_SIAH_1	0.6936
p.A894V	DO43041	UCEC	ICGC	RPAANVTPT	DEG_SIAH_1	0.6936
p.P882S	TCGA-B6-A0RV	BRCA	TCGA	RPAANVTPT	DEG_SIAH_1	0.0833
p.P882S	DO4167	BRCA	ICGC	RPAANVTPT	DEG_SIAH_1	0.0833
p.P898S	TCGA-EE-A182	SKCM	TCGA	RPAANVTPT	DEG_SIAH_1	0.6752
p.P898S	TCGA-HU-8608	STAD	TCGA	RPAANVTPT	DEG_SIAH_1	0.6752
p.P898S	DO37814	SKCM	ICGC	RPAANVTPT	DEG_SIAH_1	0.6752
p.P898S	DO47841	STAD	ICGC	RPAANVTPT	DEG_SIAH_1	0.6752
p.P898L	TCGA-EE-A2M5	SKCM	TCGA	RPAANVTPT	DEG_SIAH_1	0.7582
p.P898L	DO37425	SKCM	ICGC	RPAANVTPT	DEG_SIAH_1	0.7582
p.L890F	TCGA-FR-A8YC	SKCM	TCGA	RPAANVTPT	DEG_SIAH_1	0.3056
p.L890F	DO50301	SKCM	ICGC	RPAANVTPT	DEG_SIAH_1	0.3056
p.Y884C	SIDM00217	Colorectal Carcinoma	GDSC	RPAANVTPT	DEG_SIAH_1	0.1389
p.V896G	SIDM00951	T-Lymphoblastic Leukemia	GDSC	RPAANVTPT	DEG_SIAH_1	0.7532
p.V896G	ACH-002222	Leukemia	CCLE	RPAANVTPT	DEG_SIAH_1	0.7532
p.V896G	CTV-1	haematopoietic_and_lymphoid_tissue	COSMIC	RPAANVTPT	DEG_SIAH_1	0.7532
p.V890G	CTV-1	haematopoietic_and_lymphoid_tissue	COSMIC	RPAANVTPT	DEG_SIAH_1	0.3056
p.S886Y	NCI-H1688	lung	COSMIC	RPAANVTPT	DEG_SIAH_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P49792	E3 SUMO-protein ligase RanBP2	DEG_SIAH_1	890:898	RPAANVTPT	SIAH1,SIAH2,SIAH3	0.9981	More...
Q99666	RANBP2-like and GRIP domain-containing protein 5/6	DEG_SIAH_1	890:898	RPAANVTPT	SIAH1,SIAH2,SIAH3	0.9902	More...
A6NKT7	RanBP2-like and GRIP domain-containing protein 3	DEG_SIAH_1	891:899	RPAANVTPT	SIAH1,SIAH2,SIAH3	0.9985	More...
O14715	RANBP2-like and GRIP domain-containing protein 8	DEG_SIAH_1	890:898	RPAANVTPT	SIAH1,SIAH2,SIAH3	0.9902	More...
P0DJD0	RANBP2-like and GRIP domain-containing protein 1	DEG_SIAH_1	875:883	RPAANVTPT	SIAH1,SIAH2,SIAH3	0.9983	More...
P0DJD1	RANBP2-like and GRIP domain-containing protein 2	DEG_SIAH_1	883:891	RPAANVTPT	SIAH1,SIAH2,SIAH3	0.9973	More...
Q7Z3J3	RanBP2-like and GRIP domain-containing protein 4	DEG_SIAH_1	891:899	RPAANVTPT	SIAH1,SIAH2,SIAH3	0.9992	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons