DegronMD - O14715(RGPD8)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.N894S	TCGA-19-5956	GBM	TCGA	RPAANVTPT	DEG_SIAH_1	890:898	Mutation altering degron motif	0.5958
p.V1519I	TCGA-A3-3367	KIRC	TCGA	VSSTS	DEG_SPOP_SBC_1	1521:1525	Mutation rewiring degron network	0.2778
p.S1486T	TCGA-B8-5550	KIRC	TCGA	LITPHVS	DEG_SCF_FBW7_1	1472:1478	Mutation blocking phosphorylation signal	0.5556
p.E1485D	TCGA-B8-5550	KIRC	TCGA	LITPHVS	DEG_SCF_FBW7_1	1472:1478	Mutation rewiring degron network	0.1389
p.R1484K	TCGA-CV-A6K1	HNSC	TCGA	LITPHVS	DEG_SCF_FBW7_1	1472:1478	Mutation rewiring degron network	0.1667
p.S1471Y	TCGA-EO-A22X	UCEC	TCGA	LITPHVS	DEG_SCF_FBW7_1	1472:1478	Mutation blocking phosphorylation signal	0.75
p.A1516S	TCGA-SX-A7SM	KIRP	TCGA	VSSTS	DEG_SPOP_SBC_1	1521:1525	Mutation rewiring degron network	0.1944
p.A1516V	TCGA-VQ-A8P2	STAD	TCGA	VSSTS	DEG_SPOP_SBC_1	1521:1525	Mutation rewiring degron network	0.1944
p.R814W	DO8336	COAD	ICGC	DRNSLLNMI	DEG_APCC_DBOX_1	806:814	Mutation altering degron motif	0.8634
p.R814W	DO51779	STAD	ICGC	DRNSLLNMI	DEG_APCC_DBOX_1	806:814	Mutation altering degron motif	0.8634
p.G813D	DO50452	ESAD	ICGC	DRNSLLNMI	DEG_APCC_DBOX_1	806:814	Mutation altering degron motif	0.7198
p.G813D	DO47717	STAD	ICGC	DRNSLLNMI	DEG_APCC_DBOX_1	806:814	Mutation altering degron motif	0.7198
p.G813D	DO42568	UCEC	ICGC	DRNSLLNMI	DEG_APCC_DBOX_1	806:814	Mutation altering degron motif	0.7198
p.D803Y	DO11878	GBM	ICGC	DRNSLLNMI	DEG_APCC_DBOX_1	806:814	Mutation rewiring degron network	0.25
p.K798M	DO10880	GBM	ICGC	DRNSLLNMI	DEG_APCC_DBOX_1	806:814	Mutation rewiring degron network	0.1111
p.R812S	DO50988	LAML	ICGC	DRNSLLNMI	DEG_APCC_DBOX_1	806:814	Mutation altering degron motif	0.7427
p.R812S	DO51025	LAML	ICGC	DRNSLLNMI	DEG_APCC_DBOX_1	806:814	Mutation altering degron motif	0.7427
p.Q824K	DO45438	LUSC	ICGC	DRNSLLNMI	DEG_APCC_DBOX_1	806:814	Mutation rewiring degron network	0.0556
p.E797G	DO38376	STAD	ICGC	DRNSLLNMI	DEG_APCC_DBOX_1	806:814	Mutation rewiring degron network	0.0833
p.T804I	DO41752	UCEC	ICGC	DRNSLLNMI	DEG_APCC_DBOX_1	806:814	Mutation rewiring degron network	0.2778
p.P799H	DO41572	UCEC	ICGC	DRNSLLNMI	DEG_APCC_DBOX_1	806:814	Mutation blocking phosphorylation signal	0.5833
p.R812M	DO41361	UCEC	ICGC	DRNSLLNMI	DEG_APCC_DBOX_1	806:814	Mutation altering degron motif	0.8632
p.R818C	DO43979	UCEC	ICGC	DRNSLLNMI	DEG_APCC_DBOX_1	806:814	Mutation rewiring degron network	0.2222
p.R818C	JVM-3	haematopoietic and lymphoid tissue	COSMIC	DRNSLLNMI	DEG_APCC_DBOX_1	806:814	Mutation rewiring degron network	0.2222
p.T1529P	ACH-000370	Brain Cancer	CCLE	VSSTS	DEG_SPOP_SBC_1	1521:1525	Mutation blocking phosphorylation signal	0.6667
p.T1737M	ACH-000755	Breast Cancer	CCLE	ERERLLPVI	DEG_APCC_DBOX_1	1727:1735	Mutation rewiring degron network	0.2778
p.S1534Y	ACH-000913	Endometrial/Uterine Cancer	CCLE	VSSTS	DEG_SPOP_SBC_1	1521:1525	Mutation blocking phosphorylation signal	0.5278
p.R1533Q	NCI-H2081	lung	COSMIC	VSSTS	DEG_SPOP_SBC_1	1521:1525	Mutation rewiring degron network	0.1111
p.L800F	SCC90	upper aerodigestive tract	COSMIC	DRNSLLNMI	DEG_APCC_DBOX_1	806:814	Mutation rewiring degron network	0.1667
p.V820A	EN	endometrium	COSMIC	DRNSLLNMI	DEG_APCC_DBOX_1	806:814	Mutation rewiring degron network	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RGPD8

UniProt ID: O14715

Entrez ID: 727851

Protein name: RANBP2-like and GRIP domain-containing protein 8 (Ran-binding protein 2-like 3) (RanBP2-like 3) (RanBP2L3)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for RGPD8 in