DegronMD

Uniprot ID: O14715

Source protein: RANBP2-like and GRIP domain-containing protein 8

Source gene: RGPD8

Class: DEG_APCC_DBOX_1

Location: 1727:1735

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6204

ASA_SCORE: 47.9444

COIL: 0.1707

CONS_SCORE: 0.4307

DSS_SCORE: 0.2409

HELIX: 0.8136

FCONS_SCORE: 1.2231

RIG_SCORE: 0.828

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T1737M	ACH-000755	Breast Cancer	CCLE	ERERLLPVI	DEG_APCC_DBOX_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q99666	RANBP2-like and GRIP domain-containing protein 5/6	DEG_APCC_DBOX_1	1727:1735	ERERLLPVI	APC,CDC20,FZR1	0.6573	More...
O14715	RANBP2-like and GRIP domain-containing protein 8	DEG_APCC_DBOX_1	1727:1735	ERERLLPVI	APC,CDC20,FZR1	0.6204	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons