DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
ERERLLPVI
Uniprot ID:
Q99666
Source protein:
RANBP2-like and GRIP domain-containing protein 5/6
Source gene:
RGPD5; RGPD6
Class:
DEG_APCC_DBOX_1
Location:
1727:1735
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.6573
ASA_SCORE:
49.4889
COIL:
0.1619
CONS_SCORE:
0.4296
DSS_SCORE:
0.232
HELIX:
0.8248
FCONS_SCORE:
1.2271
RIG_SCORE:
0.8289
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with RGPD5; RGPD6 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of ERERLLPVI
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q99666
RANBP2-like and GRIP domain-containing protein 5/6
DEG_APCC_DBOX_1
1727:1735
ERERLLPVI
APC,CDC20,FZR1
0.6573
More...
O14715
RANBP2-like and GRIP domain-containing protein 8
DEG_APCC_DBOX_1
1727:1735
ERERLLPVI
APC,CDC20,FZR1
0.6204
More...