DegronMD

Uniprot ID: O14715

Source protein: RANBP2-like and GRIP domain-containing protein 8

Source gene: RGPD8

Class: DEG_APCC_DBOX_1

Location: 806:814

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7852

ASA_SCORE: 68.5222

COIL: 0.344

CONS_SCORE: 0.2935

DSS_SCORE: 0.4455

HELIX: 0.635

FCONS_SCORE: 0.9614

RIG_SCORE: 0.818

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R814W	DO8336	COAD	ICGC	DRNSLLNMI	DEG_APCC_DBOX_1	0.8634
p.R814W	DO51779	STAD	ICGC	DRNSLLNMI	DEG_APCC_DBOX_1	0.8634
p.G813D	DO50452	ESAD	ICGC	DRNSLLNMI	DEG_APCC_DBOX_1	0.7198
p.G813D	DO47717	STAD	ICGC	DRNSLLNMI	DEG_APCC_DBOX_1	0.7198
p.G813D	DO42568	UCEC	ICGC	DRNSLLNMI	DEG_APCC_DBOX_1	0.7198
p.D803Y	DO11878	GBM	ICGC	DRNSLLNMI	DEG_APCC_DBOX_1	0.25
p.K798M	DO10880	GBM	ICGC	DRNSLLNMI	DEG_APCC_DBOX_1	0.1111
p.R812S	DO50988	LAML	ICGC	DRNSLLNMI	DEG_APCC_DBOX_1	0.7427
p.R812S	DO51025	LAML	ICGC	DRNSLLNMI	DEG_APCC_DBOX_1	0.7427
p.Q824K	DO45438	LUSC	ICGC	DRNSLLNMI	DEG_APCC_DBOX_1	0.0556
p.E797G	DO38376	STAD	ICGC	DRNSLLNMI	DEG_APCC_DBOX_1	0.0833
p.T804I	DO41752	UCEC	ICGC	DRNSLLNMI	DEG_APCC_DBOX_1	0.2778
p.P799H	DO41572	UCEC	ICGC	DRNSLLNMI	DEG_APCC_DBOX_1	0.5833
p.R812M	DO41361	UCEC	ICGC	DRNSLLNMI	DEG_APCC_DBOX_1	0.8632
p.R818C	DO43979	UCEC	ICGC	DRNSLLNMI	DEG_APCC_DBOX_1	0.2222
p.R818C	JVM-3	haematopoietic_and_lymphoid_tissue	COSMIC	DRNSLLNMI	DEG_APCC_DBOX_1	0.2222
p.L800F	SCC90	upper_aerodigestive_tract	COSMIC	DRNSLLNMI	DEG_APCC_DBOX_1	0.1667
p.V820A	EN	endometrium	COSMIC	DRNSLLNMI	DEG_APCC_DBOX_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q99666	RANBP2-like and GRIP domain-containing protein 5/6	DEG_APCC_DBOX_1	806:814	DRNSLLNMI	APC,CDC20,FZR1	0.5326	More...
O14715	RANBP2-like and GRIP domain-containing protein 8	DEG_APCC_DBOX_1	806:814	DRNSLLNMI	APC,CDC20,FZR1	0.7852	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons