DegronMD

Uniprot ID: Q99666

Source protein: RANBP2-like and GRIP domain-containing protein 5/6

Source gene: RGPD5; RGPD6

Class: DEG_APCC_DBOX_1

Location: 806:814

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5326

ASA_SCORE: 64.7

COIL: 0.3748

CONS_SCORE: 0.2933

DSS_SCORE: 0.4455

HELIX: 0.595

FCONS_SCORE: 0.9595

RIG_SCORE: 0.818

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R807Q	DO52376	LUSC	ICGC	DRNSLLNMI	DEG_APCC_DBOX_1	0.7329
p.E798G	DO52350	LUSC	ICGC	DRNSLLNMI	DEG_APCC_DBOX_1	0.1111
p.E798G	ACH-000316	Liver Cancer	CCLE	DRNSLLNMI	DEG_APCC_DBOX_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q99666	RANBP2-like and GRIP domain-containing protein 5/6	DEG_APCC_DBOX_1	806:814	DRNSLLNMI	APC,CDC20,FZR1	0.5326	More...
O14715	RANBP2-like and GRIP domain-containing protein 8	DEG_APCC_DBOX_1	806:814	DRNSLLNMI	APC,CDC20,FZR1	0.7852	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons