DegronMD

Uniprot ID: P0DJD0

Source protein: RANBP2-like and GRIP domain-containing protein 1

Source gene: RGPD1

Class: DEG_SIAH_1

Location: 875:883

E3 ligase: SIAH1,SIAH2,SIAH3

DEGRON score: 0.9983

ASA_SCORE: 80.6667

COIL: 0.8594

CONS_SCORE: 0.3943

DSS_SCORE: 0.4407

HELIX: 0.0537

FCONS_SCORE: 1.3892

RIG_SCORE: 0.7413

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P882L	TCGA-AK-3444	KIRC	TCGA	RPAANVTPT	DEG_SIAH_1	0.7582
p.P866A	COR-L321	NS	COSMIC	RPAANVTPT	DEG_SIAH_1	0.0833
p.P866A	D-423MG	central_nervous_system	COSMIC	RPAANVTPT	DEG_SIAH_1	0.0833
p.P866A	U-2-OS	bone	COSMIC	RPAANVTPT	DEG_SIAH_1	0.0833
p.P866A	HOP-62	lung	COSMIC	RPAANVTPT	DEG_SIAH_1	0.0833
p.P866A	TUR	haematopoietic_and_lymphoid_tissue	COSMIC	RPAANVTPT	DEG_SIAH_1	0.0833
p.P866A	DOHH-2	haematopoietic_and_lymphoid_tissue	COSMIC	RPAANVTPT	DEG_SIAH_1	0.0833
p.P866A	NCI-H1755	lung	COSMIC	RPAANVTPT	DEG_SIAH_1	0.0833
p.P866A	L-540	haematopoietic_and_lymphoid_tissue	COSMIC	RPAANVTPT	DEG_SIAH_1	0.0833
p.P866A	NCI-H196	lung	COSMIC	RPAANVTPT	DEG_SIAH_1	0.0833
p.P866A	Hs746T	stomach	COSMIC	RPAANVTPT	DEG_SIAH_1	0.0833
p.P866A	OV-90	ovary	COSMIC	RPAANVTPT	DEG_SIAH_1	0.0833
p.S878Y	NCI-H1688	lung	COSMIC	RPAANVTPT	DEG_SIAH_1	0.712
p.S870Y	NCI-H1688	lung	COSMIC	RPAANVTPT	DEG_SIAH_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P49792	E3 SUMO-protein ligase RanBP2	DEG_SIAH_1	890:898	RPAANVTPT	SIAH1,SIAH2,SIAH3	0.9981	More...
Q99666	RANBP2-like and GRIP domain-containing protein 5/6	DEG_SIAH_1	890:898	RPAANVTPT	SIAH1,SIAH2,SIAH3	0.9902	More...
A6NKT7	RanBP2-like and GRIP domain-containing protein 3	DEG_SIAH_1	891:899	RPAANVTPT	SIAH1,SIAH2,SIAH3	0.9985	More...
O14715	RANBP2-like and GRIP domain-containing protein 8	DEG_SIAH_1	890:898	RPAANVTPT	SIAH1,SIAH2,SIAH3	0.9902	More...
P0DJD0	RANBP2-like and GRIP domain-containing protein 1	DEG_SIAH_1	875:883	RPAANVTPT	SIAH1,SIAH2,SIAH3	0.9983	More...
P0DJD1	RANBP2-like and GRIP domain-containing protein 2	DEG_SIAH_1	883:891	RPAANVTPT	SIAH1,SIAH2,SIAH3	0.9973	More...
Q7Z3J3	RanBP2-like and GRIP domain-containing protein 4	DEG_SIAH_1	891:899	RPAANVTPT	SIAH1,SIAH2,SIAH3	0.9992	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons